Investigating the Causal Relationship Between Skin Microbiota and Hypertrophic Scar Using Bidirectional Mendelian Randomization

Burns, Год журнала: 2025, Номер 51(2), С. 107376 - 107376

Опубликована: Янв. 6, 2025

Язык: Английский

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The role of the microbiome in skin cancer development and treatment

Current Opinion in Oncology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Purpose of review Recent research underscores the significant influence skin and gut microbiota on melanoma nonmelanoma cancer (NMSC) development treatment outcomes. This aims to synthesize current findings how modulates immune responses, particularly enhancing efficacy immunotherapies such as checkpoint inhibitors (ICIs). The microbiota's impact is multifaceted, involving modulation, inflammation, metabolic interactions. Beneficial strains like Bifidobacterium Lactobacillus have shown potential in supporting anti-PD-1 anti-CTLA-4 therapies by promoting T-cell activation surveillance. Evidence from preclinical clinical studies, including fecal transplantation (FMT), highlights improved response rates patients with microbiota-rich profiles. Notably, certain bacterial metabolites, inosine, contribute enhanced antitumor activity stimulating IFN-γ CD8 + T cells. Summary Understanding interplay between opens promising avenues for adjunctive therapies. Probiotic prebiotic interventions, FMT, modulation are emerging complementary strategies improve immunotherapy outcomes address resistance NMSC.

Язык: Английский

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Gut microbial predictors of first-line immunotherapy efficacy in advanced NSCLC patients

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 20, 2025

The composition of the gut microbiome patients with advanced non-small cell lung cancer is currently considered a factor influencing effectiveness treatment immune checkpoint inhibitors. We aimed to evaluate baseline in before receiving first-line immunotherapy alone or combined chemoimmunotherapy. performed 16S rRNA sequencing based on hypervariable regions. Stool samples were collected from 52 NSCLC treated chemoimmunotherapy treatment. found that Ruminococcaceae family, species Alistipes sp. genus Eubacterium ventriosum group and Marvinbryantia may be intestinal, microbiological predictors response Genus Akkermansia [Clostridum] leptum predicted length PFS (progression-free survival). Longer OS (overall survival) associated bacteria family genera [Eubacterium] group, Marvinbryantia, Colidextribacter leptum. Bacteria have an adverse effect (shortening OS) using inhibitors are Rothia genus, Streptococus salivarius, Streptococus, Family XIII AD3011 s. uncultured bacterium. intestinal flora can predictive for patients. Specific positively negatively treatment, progression-free survival, overall survival. They potentially used as markers immunotherapy.

Язык: Английский

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A bidirectional Mendelian randomisation study of the association between gut microbiota and malignant non-melanoma skin cancer

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Апрель 23, 2024

Gut microbiota are suggested to be associated with a variety of cancers.However, the correlation between gut and development malignant non-melanoma skin cancer (MNMSC) remains unknown. Thus, this study employed bidirectional Mendelian randomisation (MR) method investigate potentially causal association MNMSC. Here detailed genetic data on available from MiBioGen consortium Dutch Microbiota Project were analysed, as well MNMSC UK Biobank.Several sophisticated statistical methods involving inverse variance weighting, weighted median estimator, MR Egger, simple mode-based estimator models utilised assess potential Reverse sensitivity analyses also performed. Eight identified causally related Genera Holdemanella (odds ratio [OR]=0.99, 95% confidence interval [CI]: 0.99–1.00, 4.5×10-3), Ruminococcaceae UCG014 (OR=0.99, CI: P=1.3×10-2), Sutterella P=4.2×10-2), Bifidobacterium adolescentis P=8.8×10-3), Bacteroides dorei (OR=1.00, P=9.9×10-3), family Veillonellaceae 0.99–1.00,P=3.8×10-4) negatively correlated Clostridia (OR=1.01, 1.00–1.02, P=2.1×10-3) Clostridiales positively The was more pronounced following Bonferroni correction. No relationship determined any these eight by reverse analysis. This suggests that specific have effects indicates certain may effect modulation means prevent

Язык: Английский

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Mendelian randomization study of the association between cathepsins and melanoma

World Academy of Sciences Journal, Год журнала: 2024, Номер 6(5)

Опубликована: Июль 3, 2024

Malignant melanoma is a skin tumor with poor prognosis. Therefore, it critical to explore the risk factors associated outcome of this tumor. In present study, Mendelian randomization (MR) was used investigate causal association between cathepsins and malignant melanoma. Summary statistical data on five from European participants were extracted as exposure data. Data genome‑wide study ancestry Single nucleotide polymorphisms instrumental variables (IVs). including 3,751 cases 372,016 controls, MR analysis conducted examine effects these IVs The inverse variance‑weighted method for analysis. addition, MR‑Egger, weighted median pleiotropy residual sum complementary analyses. Furthermore, series sensitivity analyses performed ensure validity robustness results. gene‑predicted results indicated no (P>0.05). Cathepsin S [odds ratio (OR), 1.000; 95% confidence interval (CI), 0.999‑1.001; P=0.943], cathepsin B (OR, CI, P=0.763), O P=0.646), E 0.999; 0.998‑1.001; P=0.375) L2 1.101; 0.831‑1.458; P=0.503) not significantly developing Sensitivity demonstrated significant bias in aforementioned On whole, did provide evidence that (cathepsin S, B, O, L2) are causally related

Язык: Английский

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Causal roles of skin and gut microbiota in skin appendage disorders suggested by genetic study

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Сен. 10, 2024

There is evidence from observational studies that human microbiota linked to skin appendage Disorders (SADs). Nevertheless, the causal association between and SADs yet be fully clarified.

Язык: Английский

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