Cytokines in gingivitis and periodontitis: from pathogenesis to therapeutic targets

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Авг. 26, 2024

Chronic inflammatory processes in the oral mucosa and periodontitis are common disorders caused by microflora microbial biofilms. These factors activate both innate adaptive immune systems, leading to production of pro-inflammatory cytokines. Cytokines known play a crucial role pathogenesis gingivitis have been proposed as biomarkers for diagnosis follow-up these diseases. They can stromal cells, local inflammation tissue damage. This damage include destruction periodontal ligaments, gingiva, alveolar bone. Studies reported increased levels cytokines, such interleukin-1beta (IL-1beta), tumor necrosis factor (TNF), IL-6, IL-17, IL-23, patients with periodontitis. In experimental models periodontitis, TNF IL-23/IL-17 axis pivotal disease pathogenesis. Inactivation pathways through neutralizing antibodies, genetic engineering or IL-10 function has demonstrated reduce activity. review discusses cytokines particular emphasis on their mediating destruction. It also explores new therapeutic interventions that offer potential research clinical therapy chronic

Язык: Английский

---

Beyond Amyloid and Tau: The Critical Role of Microglia in Alzheimer’s Disease Therapeutics

Biomedicines, Год журнала: 2025, Номер 13(2), С. 279 - 279

Опубликована: Янв. 23, 2025

Alzheimer’s disease (AD) is traditionally viewed through the lens of amyloid cascade hypothesis, implicating amyloid-beta and tau protein aggregates as main pathological culprits. However, burgeoning research points to brain’s resident immune cells, microglia, critical players in AD pathogenesis, progression, potential therapeutic interventions. This review examines dynamic roles microglia within intricate framework AD. We detail involvement these cells neuroinflammation, explaining how their activation response fluctuations may influence trajectory. further elucidate complex relationship between pathology. study highlights dual nature which contribute both aggregation clearance protein. Moreover, an in-depth analysis interplay unveils significant, yet often overlooked, impact this interaction on neurodegeneration Shifting from conventional approaches, we assess current treatments primarily targeting introduce novel strategies that involve manipulating microglial functions. These innovative methods herald a paradigm shift management Finally, explore field precision diagnosis pursuit robust biomarkers. underline more profound comprehension biology could enrich essential areas, potentially paving way for accurate diagnostic tools tailored treatment strategies. In conclusion, expands perspective pathology treatment, drawing attention multifaceted microglia. As continue enhance our understanding microglial-focused interventions emerge promising frontier bolster arsenal fight against

Язык: Английский

---

Changes in Concentration of Selected Biomarkers of Exposure in Users of Classic Cigarettes, E-Cigarettes, and Heated Tobacco Products—A Narrative Review

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1796 - 1796

Опубликована: Фев. 20, 2025

Currently, the number of e-cigarette and heated tobacco product (HTP) users are steadily increasing, while classic cigarette decreasing. The effects smoking cigarettes on human health have been thoroughly described in literature, but negative e-cigarettes HTPs body not clearly defined. Among different forms tobacco, those at a particularly high risk developing particular disease entities should be identified, allowing for faster implementation potential treatments, including psychotherapeutic ones. Biomarkers used this purpose. This paper summarizes these compounds from exposure groups cigarettes, e-cigarettes, HTPs, presents changes their concentrations fluids users. review discusses impact use relation to levels following biomarkers: TNF-α, IL-1β, IL-6, IL-8, IL-17, IFN-γ, IL-10, IL-4, Il-13, TGF-β, VEGF EGF, HGF, BDNF, MMP-9, CRP, microplastics, selected parameters oxidative stress. also includes suggested treatment, Tobacco Product Use Reduction Programs, minimize above-mentioned products.

Язык: Английский

---

Low‐grade systemic inflammation biomarkers in sedentary young healthy adults are not significantly affected by a 24‐week concurrent training intervention

Annals of the New York Academy of Sciences, Год журнала: 2025, Номер unknown

Опубликована: Апрель 12, 2025

In this study, we measured the dose-response effect of a 24-week concurrent training (CT) intervention on low-grade systemic inflammation biomarkers in sedentary young healthy adults. A total 100 untrained participants were randomized to (1) no exercise (control group, n = 35), (2) aerobic + resistance at moderate intensity (exercise-moderate group; 33), or (3) CT vigorous (exercise-vigorous 32). Serum concentrations C-reactive protein (CRP), interleukin-6 (IL-6), IL-7, IL-8, and IL-10, interferon-gamma (IFN-γ), tumor necrosis factor-α, leptin, adiponectin determined compared among three groups. The exercise-vigorous group members had lower differences IL-7 levels them, exercise-moderate (Δ ‒7.97% vs. 1.90%; p 0.030; 95% CI [‒0.90, ‒0.04]). showed higher CRP values 20.1%; F 3.339; 0.046) both control ‒1.91%) ‒23.3%) members, whereas exhibited IFN-γ 15.3% 2.62%; 0.048; [‒0.68, ‒0.01]). For individuals groups, body composition physical fitness correlated overall with leptin. data show, concluded, that significant biomarkers.

Язык: Английский

---

Neuroprotective Effect of Curcumin–Metavanadate in the Hippocampus of Aged Rats

Synapse, Год журнала: 2025, Номер 79(1)

Опубликована: Янв. 1, 2025

ABSTRACT Brain aging is a multifactorial process that includes reduction in the biological and metabolic activity of individuals. Oxidative stress inflammatory processes are characteristic brain aging. Given current problems, need arises to implement new therapeutic approaches. Polyoxidovanadates (POV), as well curcumin, have stood out for their participation variety activities. This work aimed evaluate coupling metavanadate curcumin (Cuma‐MV) on learning, memory, redox balance, neuroinflammation, cell death hippocampal region (CA1 CA3) dentate gyrus (DG) aged rats. Rats 18 months old were administered daily dose (Cuma), sodium (MV), or Cuma‐MV two months. The results demonstrated administration 60 days rats improved short‐ long‐term recognition decreased reactive oxygen species, substantially lipoperoxidation hippocampus. Furthermore, superoxide dismutase catalase increased animals treated with Cuma‐MV. It important highlight treatment exhibited significantly greater effect than treatments MV Cuma all parameters evaluated. Finally, we conclude represents potential option prevention cognitive decline associated

Язык: Английский

---

TLR/NLRP3 Inflammasome signaling pathways as a main target in frailty, cachexia and sarcopenia

Tissue and Cell, Год журнала: 2025, Номер 93, С. 102723 - 102723

Опубликована: Янв. 9, 2025

Язык: Английский

---

Deciphering the role of cytokines in aging: biomarker potential and effective targeting

Mechanisms of Ageing and Development, Год журнала: 2025, Номер 224, С. 112036 - 112036

Опубликована: Янв. 18, 2025

Язык: Английский

---

A Panel of Diverse Inflammatory Biomarkers Is Not Associated with BMI-Calibrated Obesity nor with Dyslipidemia or Dysglycemia in Clinically Healthy Adults Aged 20 to 40 Years

International Journal of Environmental Research and Public Health, Год журнала: 2025, Номер 22(2), С. 207 - 207

Опубликована: Янв. 31, 2025

Low-grade metabolic inflammation is associated with several chronic disorders, including obesity. However, no concrete evidence that supports obesity as a direct cause of inflammation. This study aims to identify the association in apparently healthy adults. In this study, 162 seemingly volunteers, aged between 20 and 40 years, comparable sex ratio, were recruited categorized based on their body mass index (BMI) into four scales: normal (N), overweight (OW), obese (OB), severely (SOB). After clinical examination, fasting blood samples collected from subjects for glycemic (fasting glucose-FBG, HbA1c) lipid (total cholesterol, LDL-C, HDL-C, triacyl glycerides -TAG) profile analysis. addition, plasma levels panel diverse inflammatory biomarkers, IL6, IL8, procalcitonin (PCT), TREM1, uPAR analyzed by sandwich ELISA. The results showed LDLC, TAG, FBG, HbA1c significantly higher (OB SOB) group, compared non-obese (N OW) while HDLc was lower. biomarker not correlated age or differed males females. Importantly, all assessed biomarkers classes. Moreover, dyslipidemia dysglycemia those profiles. Finally, obesity, glycemic, lipidemic parameters. correction co-morbidities, our deny discrete probably dyslipidemia, systemic Further studies local non-elderly, are needed.

Язык: Английский

---

Cerebellar Pathology in Forensic and Clinical Neuroscience

Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102697 - 102697

Опубликована: Фев. 1, 2025

Язык: Английский

---

Upcycling Fish Byproducts for Skin Health: An Enzymatic Approach to Sustainable Nutricosmetics

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106205 - 106205

Опубликована: Фев. 1, 2025

Язык: Английский

---