Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition
Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 13, 2025
The
tumor
microenvironment
(TME)
is
integral
to
cancer
progression,
impacting
metastasis
and
treatment
response.
It
consists
of
diverse
cell
types,
extracellular
matrix
components,
signaling
molecules
that
interact
promote
growth
therapeutic
resistance.
Elucidating
the
intricate
interactions
between
cells
TME
crucial
in
understanding
progression
challenges.
A
critical
process
induced
by
epithelial-mesenchymal
transition
(EMT),
wherein
epithelial
acquire
mesenchymal
traits,
which
enhance
their
motility
invasiveness
progression.
By
targeting
various
components
TME,
novel
investigational
strategies
aim
disrupt
TME's
contribution
EMT,
thereby
improving
efficacy,
addressing
resistance,
offering
a
nuanced
approach
therapy.
This
review
scrutinizes
key
players
emphasizing
avenues
therapeutically
components.
Moreover,
article
discusses
implications
for
resistance
mechanisms
highlights
current
toward
modulation
along
with
potential
caveats.
Язык: Английский
Interplay between MRI radiomics and immune gene expression signatures in oral squamous cell carcinoma
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 12, 2025
With
the
advances
in
immunotherapy
and
challenge
of
poor
responsiveness
oral
squamous
cell
carcinoma
(OSCC)
patients,
understanding
tumor
microenvironment
is
crucial.
Radiogenomics
offers
potential
to
provide
pre-operative,
non-invasive
image-derived
immune
biomarkers.
To
this
aim,
present
study
explores
capability
MRI-based
radiomics
describe
patients'
state
OSCC.
Seven
radiomic,
29
immune-related
gene
expression
signatures
were
computed
deconvolution
analysis
was
performed
for
a
subset
OSCC
from
BD2Decide
database.
A
correlation-driven
identified
key
associations
between
radiomic
populations.
Radiomic
classifiers
then
developed
evaluate
their
stratify
patients
based
on
status.
models
showed
promising
results
predicting
signature
associated
with
significant
prognostic
value
HNSCC
who
underwent
radiotherapy
(AUC
=
0.92),
suggesting
these
models'
distinguishing
radioresistant
radiosensitive
aiding
treatment
decisions.
Additionally,
reflected
infiltrating
cells
our
cohort
(M1,
CD8
+
T,
B
cells).
MRI-radiomic
could
become
methods
prognosis
choice
patients.
Based
results,
upon
external
validation,
MRI-radiomics
enhance
personalized
medicine
approaches.
Язык: Английский
Advances and challenges in CAR-T cell therapy for head and neck squamous cell carcinoma
Sahand Saeidpour Masouleh,
Kamyar Nasiri,
Ava Ostovar Ravari
и другие.
Biomarker Research,
Год журнала:
2025,
Номер
13(1)
Опубликована: Май 1, 2025
Язык: Английский
Comprehensive analysis of stearoyl-coenzyme A desaturase in prostate adenocarcinoma: insights into gene expression, immune microenvironment and tumor progression
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 16, 2024
Prostate
adenocarcinoma
(PRAD)
is
a
prevalent
global
malignancy
which
depends
more
on
lipid
metabolism
for
tumor
progression
compared
to
other
cancer
types.
Although
Stearoyl-coenzyme
A
desaturase
(SCD)
documented
regulate
in
multiple
cancers,
landscape
analysis
of
its
implications
PRAD
are
still
missing
at
present.
Here,
we
conducted
an
diverse
datasets
revealing
elevated
SCD
expression
the
cohort
both
mRNA
and
protein
levels.
Interestingly,
was
associated
with
promoter
hypermethylation
genetic
alterations,
notably
L134V
mutation.
Integration
comprehensive
immunological
genomic
data
revealed
robust
positive
correlation
between
levels
abundance
CD8
+
T
cells
macrophages.
Further
analyses
identified
significant
associations
various
immune
markers
microenvironment.
Single-cell
transcriptomic
profiling
unveiled
differential
patterns
across
distinct
cell
types
within
prostate
The
Gene
Ontology
Kyoto
Encyclopedia
Genes
Genome
showed
that
enriched
pathways
were
primarily
related
biosynthesis,
cholesterol
endoplasmic
reticulum
membrane
functions,
metabolic
pathways.
Set
Enrichment
Analysis
highlighted
involvement
crucial
cellular
processes,
including
cycle
biosynthesis
cofactors
In
functional
studies,
overexpression
promoted
proliferation,
metastasis
invasion
cells,
whereas
downregulation
inhibits
these
processes.
This
study
provides
insights
into
multifaceted
roles
pathogenesis,
underscoring
potential
as
therapeutic
target
prognostic
biomarker.
Язык: Английский
Bioinformatics-Based Analysis of the Relationship between Tumor-Infiltrating Immune Cells and the Prognosis of Head and Neck Squamous Cell Carcinoma
Hans Journal of Biomedicine,
Год журнала:
2024,
Номер
14(04), С. 573 - 582
Опубликована: Янв. 1, 2024
Язык: Английский
CTHRC1 is a prognostic biomarker correlated with immune infiltration in head and neck squamous cell carcinoma
BMC Oral Health,
Год журнала:
2024,
Номер
24(1)
Опубликована: Июнь 27, 2024
Head
and
neck
squamous
cell
carcinoma
(HNSCC)
is
the
sixth
most
common
malignancy
worldwide,
characterized
by
high
morbidity,
mortality,
poor
prognosis.
Collagen
triple
helix
repeat
containing
1
(CTHRC1)
has
been
shown
to
be
highly
expressed
in
various
cancers.
However,
its
biological
functions,
potential
role
as
a
biomarker,
relationship
with
immune
infiltrates
HNSCC
remain
unclear.
Our
principal
objective
was
analyze
CTHRC1
expression,
prognostic
implications,
effects
on
system
patients
using
bioinformatics
analysis.
Язык: Английский