PeerJ,
Год журнала:
2024,
Номер
12, С. e18348 - e18348
Опубликована: Окт. 24, 2024
tRNA-derived
small
RNAs
(tsRNAs)
are
a
novel
class
of
noncoding
RNAs,
precisely
cleaved
from
tRNA,
functioning
as
regulatory
molecules.
The
topic
tsRNAs
in
injuries
has
not
been
extensively
discussed,
and
studies
on
entering
new
era.
Here,
we
provide
fresh
perspective
this
topic.
We
systematically
reviewed
the
classification,
generation,
biological
functions
response
to
stress,
well
their
potential
biomarkers
therapeutic
targets
various
injuries,
including
lung
injury,
liver
renal
cardiac
neuronal
vascular
skeletal
muscle
skin
injury.
also
provided
association
between
stress-induced
organ
injury
clinical
perspective.
Journal of Leukocyte Biology,
Год журнала:
2024,
Номер
116(5), С. 1072 - 1079
Опубликована: Июнь 26, 2024
Abstract
Macrophages
are
essential
immune
cells
for
host
defense
against
bacterial
pathogens
after
radiation
injury.
However,
the
role
of
macrophage
phagocytosis
in
infection
following
injury
remains
poorly
examined.
Extracellular
cold-inducible
RNA-binding
protein
is
a
damage-associated
molecular
pattern
that
dysregulates
system
responses
such
as
phagocytosis.
We
hypothesized
radiation-induced
extracellular
release
impairs
bacteria.
Adult
healthy
mice
were
exposed
to
6.5
Gy
total
body
irradiation.
Primary
peritoneal
macrophages
isolated
from
adult
radiation.
protein–neutralizing
monoclonal
antibody
was
added
cell
culture
prior
Bacterial
by
assessed
using
pHrodo
Green-labeled
Escherichia
coli
7
d
irradiation
ex
vivo
and
vitro.
also
treatment
with
recombinant
murine
protein.
Rac1
ARP2
expression
lysates
levels
lavage
western
blotting.
significantly
decreased
compared
controls
downregulated
Total
increased
cavity.
Recombinant
dose-dependent
manner.
restored
Ionizing
exposure
Neutralization
restores
phagocytic
ability
Our
findings
elucidate
novel
mechanism
dysfunction
provide
potential
new
therapeutic
approach
limiting
Chinese Herbal Medicines,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 1, 2024
Nuclear
radiation
exposure
events
and
tumor
radiotherapy
are
highly
susceptible
to
a
range
of
psychological,
physiological
other
health
problems,
which
can
seriously
affect
patients'
quality
life.
It
has
been
shown
that
87.5
%
patients
exposed
varying
degrees
injury
during
radiotherapy.
The
treatment
(RI)
in
modern
medicine
is
limited
drug
therapy,
cell
etc.
Among
them,
the
most
chemical
drugs
cause
many
adverse
reactions
including
fatigue,
nausea,
vomiting,
etc.,
there
very
few
dedicated
RI.
Traditional
Chinese
(TCM)
rich
natural
medicinal
resource,
wide
pharmacological
activities,
multiple
targets
action
minimal
toxic
side
effects.
Many
studies
have
demonstrated
TCM
its
compound
preparations
enormous
potential
induced
comprehensive
diseases.
However,
clinical
application
due
slow
onset
action,
complex
active
ingredients,
low
bioavailability.
Therefore,
article
reviews
application,
molecular
mechanisms,
new
dosage
forms
prevention
On
this
basis,
we
will
focus
on
discussing
development
advantages
prospects
combination
traditional
Western
achieve
efficient
This
review
aims
provide
scientific
effective
delivery
strategies
basic
theoretical
support
for
RI
with
TCM,
further
promote
innovative
TCM.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 22, 2024
In
the
late
stages
of
COVID-19
pandemic,
there’s
an
increasing
trend
in
opportunistic
infections,
including
bacterial
and
fungal
infections.
This
study
discusses
treatment
process
two
cases
cryptococcal
meningitis
during
pandemic.
It
highlights
importance
laboratory
testing
for
these
co-infections
stresses
need
vigilance,
early
diagnosis,
proactive
to
improve
patient
outcomes
post-pandemic
era.
The
delayed
effects
of
radiation
alone
and
combined
with
skin
injury
on
the
kidney
are
poorly
understood.
We
aimed
to
unravel
compare
inflammatory,
oxidative
stress,
survival
signaling
pathways
in
cortex
before
mice
manifested
renal
dysfunction
after
these
two
injuries.
Mice
were
analyzed
30
days
post
irradiation
(9.5
Gy
for
alone,
9.0
a
wound).
Radiation
did
not
significantly
alter
BUN,
NGAL,
or
KIM-1
protein
levels,
indicating
preserved
function.
However,
had
increased
nuanced
effect
health.
activated
distinct
inflammatory
pathways.
STAT3-Y705
phosphorylation,
while
boosted
STAT1-Y701
phosphorylation.
Additionally,
mRNA
abundance
IFNγR1,
IFNγR2,
heparanase
IL-10,
tended
increase
levels
reduced
IL-4
levels.
Both
injuries
HO-1
protein,
but
also
MnSOD
catalase
proteins.
promoted
AKT1-S473
phosphorylation
diminished
p53
suggesting
inhibition
apoptosis.
In
summary,
despite
activation
stress
pathways,
both
protective
mechanisms
such
as
AKT1,
offering
insights
into
molecular
events
manifesting
dysfunction.
Radiation Research,
Год журнала:
2024,
Номер
202(4)
Опубликована: Авг. 27, 2024
Total-body
irradiation
(TBI)
with
gamma
rays
can
damage
organisms
in
various
unexpected
ways
and
trigger
several
organ
dysfunction
syndromes,
such
as
acute
radiation
syndrome
(ARS).
Hematopoietic
cells
enterocytes
are
particularly
sensitive
to
due
their
self-renewal
ability
rapid
division,
which
leads
hematopoietic
ARS
(H-ARS)
gastrointestinal
(GI-ARS).
We
previously
showed
that
a
lipid-based
small
molecule,
1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol
(PLAG),
improved
30-day
survival
alleviated
H-ARS
symptoms
BALB/c
mice
after
lethal
dose
(LD70/30)
of
gamma-ray
TBI.
In
this
study,
we
investigated
the
mitigating
effects
PLAG
on
radiation-induced
GI
occurs
under
same
conditions
mice.
Our
study
facilitated
structural
restoration
intestinal
tissues
by
increasing
villus
height,
crypt
depth,
number,
mucin-producing
goblet
cells,
proliferating
cell
nuclear
antigen
(PCNA)-positive
cells.
significantly
absorptive
capacity
reduced
injury-induced
bacterial
translocation.
addition,
effectively
inhibited
necroptosis
signaling
activation
was
responsible
for
sustained
tissue
release
high
mobility
group
box
1
(HMGB1),
typical
damage-associated
molecular
pattern.
Overall,
our
findings
support
radiation-mitigating
potential
against
GI-ARS
accidental
exposure.
Ulyanovsk Medico-biological Journal,
Год журнала:
2024,
Номер
3, С. 98 - 106
Опубликована: Сен. 24, 2024
Exposure
to
ionizing
radiation
while
treating
malignant
liver
tumors
causes
radiation-induced
hepatitis.
Under
electron
irradiation,
ascorbic
acid
may
be
a
potential
radioprotector.
Objective.
The
aim
of
the
study
is
conduct
immunohistochemical
assessment
IL-1β,
IL-6,
IL-10
expression
levels
after
administration
in
hepatitis
model.
Materials
and
Methods.
Wistar
rats
(n=40)
were
divided
into
four
groups:
Group
1
(n=10)
–
control;
2
30
Gy;
3
before
irradiation;
4
acid.
One
week
last
fraction,
animals
withdrawn
from
experiment.
Liver
fragments
examined
morphologically,
immunohistochemically
using
ELISA
method
(IL-1β,
IL-10).
Statistical
analysis
obtained
data
was
performed
Post-hoc
test
for
Kruskal-Wallis:
Dunn's
Test.
Multiple
comparisons
Mann-Whitney
U
test.
Results.
Electron
irradiation
resulted
sharp
increase
inflammatory
factors
cytokine
imbalance
with
predominance
proinflammatory
markers
IL-6)
over
anti-inflammatory
ones
(IL-10).
In
group
pre-radiation
acid,
interleukins
also
exceeded
control
values.
However,
balance
pro-
partially
preserved.
Conclusion.
A
exposure
local
(total
dose
Gy),
signs
observed.
statistically
significant
cytokines
detected
liver.
At
same
time,
provides
partial
radioprotection
healthy
hepatocytes,
as
well
restoration
decrease
cellular
infiltration.
PeerJ,
Год журнала:
2024,
Номер
12, С. e18348 - e18348
Опубликована: Окт. 24, 2024
tRNA-derived
small
RNAs
(tsRNAs)
are
a
novel
class
of
noncoding
RNAs,
precisely
cleaved
from
tRNA,
functioning
as
regulatory
molecules.
The
topic
tsRNAs
in
injuries
has
not
been
extensively
discussed,
and
studies
on
entering
new
era.
Here,
we
provide
fresh
perspective
this
topic.
We
systematically
reviewed
the
classification,
generation,
biological
functions
response
to
stress,
well
their
potential
biomarkers
therapeutic
targets
various
injuries,
including
lung
injury,
liver
renal
cardiac
neuronal
vascular
skeletal
muscle
skin
injury.
also
provided
association
between
stress-induced
organ
injury
clinical
perspective.
