Vesículas Extracelulares de Probióticos e Psoríase: Promessa Terapêutica ou Realidade? – Uma Revisão Integrativa
Silvia Stanica,
Mariana Etchepare,
Marcia Regina Pincerati
и другие.
Revista Sociedade Científica,
Год журнала:
2025,
Номер
8(1), С. 434 - 452
Опубликована: Фев. 3, 2025
A
psoríase
é
uma
doença
inflamatória
crônica
que
acomete
2-3%
da
população
global
,
caracterizando-se
por
lesões
cutâneas
persistentes,
desregulação
imunológica,
e
significativa
redução
na
qualidade
de
vida
dos
indivíduos
afetados.
Apesar
avanços
terapêuticos
as
opções
disponíveis
,como
tratamentos
tópicos,
sistêmicos
biológicos
enfrentam
desafios
relacionados
à
eficácia
limitada,
efeitos
adversos
altos
custos,
destacando
a
necessidade
abordagens
terapêuticas
inovadoras.
Nesse
contexto,
vesículas
extracelulares
derivadas
probióticos
(VEs
)
têm
emergido
como
estratégia
promissora
devido
suas
propriedades
imunomoduladoras
anti-inflamatórias.
Os
achados
indicam
VEs
cepas
Lactobacillus
plantaram
L.casei
L.murinus
Propionibacterium
freudenreichii
apresentam
capacidade
modular
processos
inflamatórios
ao
suprimir
citocinas
pró-
inflamatórias
(TNF-alfa
IL-17)
aumentar
produção
anti-inflamatórias
(IL-10).
Além
disso
promovem
polarização
do
macrófagos
para
o
fenótipo
M2
favorecendo
resolução
inflamação
regeneração
tecidual
modulam
vias
sinalização
intracelular
NF-kB
contribuindo
restauração
homeostase
tecidual.Esses
mecanismos
sugerem
um
relevante
potencial
terapêutico
das
no
manejo
doenças
crônicas
incluindo
reforçam
viabilidade
seu
uso
em
estratégias
tópicas
personalizadas.
Hydrogen-rich water ameliorates imiquimod-induced psoriasis-like skin lesions and regulates macrophage polarization in dyslipidemic ApoE-deficient mice
Qiu Zhihui,
Ailing Huang,
Z Li
и другие.
European Journal of Pharmacology,
Год журнала:
2025,
Номер
992, С. 177363 - 177363
Опубликована: Фев. 7, 2025
Язык: Английский
Association between body roundness index and psoriasis: a cross-sectional study
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 28, 2025
This
study
aimed
to
elucidate
the
association
between
body
roundness
index
(BRI),
an
indicator
of
abdominal
obesity,
and
odds
developing
psoriasis.
We
conducted
a
comprehensive,
multi-ethnic
cross-sectional
analysis
utilizing
data
from
National
Health
Nutrition
Examination
Survey
(NHANES).
Height
weight
measurements
were
obtained
database,
recorded
by
trained
personnel
using
standardized
equipment.
In
addition,
demographic
clinical
information
was
collected
via
questionnaires.
The
BRI
psoriasis
assessed
multivariable
weighted
logistic
regression
models,
relationship
further
visualized
through
restricted
cubic
spline
(RCS)
curves.
Subgroup
analyses
explore
this
across
different
populations,
sensitivity
performed
unweighted
methods
validate
findings.
encompassed
21,242
participants,
whom
562
diagnosed
with
Comparative
characteristics
non-psoriasis
groups
revealed
statistically
significant
differences.
demonstrated
positive
occurrence
psoriasis,
considered
both
as
continuous
categorical
variable.
Specifically,
each
unit
increase
in
associated
9%
(95%
confidence
interval:
4%
13%).
RCS
curves
indicated
progressive
rising
levels.
consistently
showed
correlation
diverse
populations.
corroborated
main
findings,
underscoring
robustness
our
conclusions.
Our
findings
establish
reliable
BRI,
marker
various
Язык: Английский
Emerging risk factors for heart failure in younger populations: A growing public health concern
World Journal of Cardiology,
Год журнала:
2025,
Номер
17(4)
Опубликована: Апрель 21, 2025
Heart
failure
(HF)
is
a
growing
public
health
concern,
with
an
increasing
incidence
among
younger
populations.
Traditionally,
HF
was
considered
condition
primarily
affecting
the
elderly,
but
of
late,
emerging
evidence
hints
at
rapidly
rising
in
youth
past
2
decades.
has
been
linked
to
complex
interaction
between
risk
factors,
such
as
metabolic
syndrome,
environmental
exposures,
genetic
predispositions,
and
lifestyle
behaviors.
This
review
examines
these
evolving
determinants,
including
substance
abuse,
autoimmune
diseases,
long-term
cardiovascular
effects
coronavirus
disease
2019,
which
disproportionately
affect
individuals.
Through
comprehensive
analysis,
study
highlights
importance
early
detection,
targeted
prevention
strategies,
multidisciplinary
management
approaches
address
this
alarming
trend.
Promoting
awareness
integrating
age-specific
interventions
could
significantly
reduce
burden
improve
outcomes
Язык: Английский
Epidemiology of lipid disturbances in psoriasis: An analysis of trends from 2006 to 2023
Diabetes & Metabolic Syndrome Clinical Research & Reviews,
Год журнала:
2024,
Номер
18(8), С. 103098 - 103098
Опубликована: Авг. 1, 2024
Язык: Английский
Pleiotropic effects of netakimab in patients with psoriatic arthritis, spondylitis and comorbid metabolic syndrome or a new opportunity for weight control? Case report
Terapevticheskii arkhiv,
Год журнала:
2024,
Номер
96(12), С. 1230 - 1237
Опубликована: Дек. 27, 2024
The
article
presents
the
results
of
studying
efficacy
netakimab
(Efleira)
in
complex
treatment
patients
with
psoriasis,
psoriatic
arthritis,
spondylitis
and
concomitant
metabolic
syndrome.
study
included
observations
clinical
manifestations
diseases
changes
after
use
netakimab.
As
a
result
treatment,
there
was
an
improvement
not
only
symptoms,
but
also
syndrome
parameters.
In
all
3
treated
netakimab,
decrease
activity
sacroileitis,
accompanied
by
weight
loss,
which
indicates
pleiotropic
effect
this
drug.
described
cases
are
interest
to
rheumatologists,
dermatologists,
endocrinologists,
therapists,
general
practitioners,
illustrate
successful
as
interleukin-17
inhibitor.
Язык: Английский