bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Сен. 16, 2024
Abstract Psoriasis is an immune mediated, chronic inflammatory skin disease. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have inherent immunomodulatory potency from their parental cells, the mesenchymal cells (MSCs). In this study, we revealed application potential of MSC-EVs to alleviate psoriatic symptoms in imiquimod-induced psoriasis mouse model.
Язык: Английский
Tissue and Cell, Год журнала: 2024, Номер 89, С. 102415 - 102415
Опубликована: Май 27, 2024
Язык: Английский
Процитировано
10
Journal of Advanced Research, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 6973 - 6973
Опубликована: Июнь 26, 2024
The risks of severe ionizing radiation exposure are increasing due to the involvement nuclear powers in combat operations, use power, and existence terrorist threats. Exposure a whole-body dose above about 0.7 Gy results H-ARS (hematopoietic acute syndrome), which is characterized by damage hematopoietic system; higher doses result further gastrointestinal nervous systems. Only few medical countermeasures for ARS currently available approved use, although others development. Cell therapies (cells or products produced cells) complex therapeutics that show promise treatment injury have been shown reduce mortality morbidity animal models. Since clinical trials cannot be ethically conducted, testing extremely important. Here, we describe cell tested Both cells appear promote survival lessen tissue after irradiation, mechanisms not clear. Because often occurs conjunction with other traumatic injuries, models combined involving future countermeasure these problems also discussed.
Язык: Английский
Процитировано
3
Experimental Hematology and Oncology, Год журнала: 2024, Номер 13(1)
Опубликована: Июль 1, 2024
Abstract Immune checkpoint blockade (ICB) necessitates a thorough understanding of intricate cellular interactions within the tumor microenvironment (TME). Mesenchymal stromal cells (MSCs) play pivotal role in cancer generation, progression, and immunosuppressive microenvironment. Within TME, MSCs encompass both resident circulating counterparts that dynamically communicate actively participate TME immunosurveillance response to ICB. This review aims reevaluate various facets MSCs, including their potential self-transformation function as cancer-initiating contributions creation conducive environment for proliferation metastasis. Additionally, we explore immune regulatory functions tumor-associated (TA-MSCs) MSC-derived extracellular vesicles (MSC-EVs) with analysis connections between tissue-resident MSCs. A comprehensive dynamics MSC-immune cell communication heterogeneous cargo tumor-educated versus naïve may unveil new MSC-mediated pathway can be targeted enhance control by
Язык: Английский
Процитировано
3
Medical Science Monitor, Год журнала: 2024, Номер 30
Опубликована: Июль 23, 2024
Mesenchymal stem cells (MSCs) are a promising tool that may be used in regenerative medicine. Thanks to their ability differentiate and paracrine signaling, they can the treatment of many diseases. Undifferentiated MSCs support regeneration surrounding tissues through secreted substances exosomes. This is possible thanks production growth factors. These factors stimulate neighboring cells, have an anti-apoptotic effect, angiogenesis, also immunomodulatory effect. The level vary depending on Apart from donor's health condition, it influenced by source MSCs, methods harvesting, even banking cells. work review research how patient's condition affects properties obtained MSCs. discusses impact diabetes, obesity, autoimmune diseases, inflammation, as well harvesting phenotype, differentiation capacity, anti-inflammatory, angiogenic effects, proliferation potential Knowledge about specific clinical allows for better use more appropriate targeting procedures collecting, multiplying, these subsequent use. article aims characteristics, banking, signaling role inflammatory
Язык: Английский
Процитировано
1
Stem Cells Translational Medicine, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 19, 2024
Abstract Given the high heterogeneity of type 2 diabetes mellitus (T2DM), it is imperative to develop personalized stem cell infusion regimen for targeted metabolic phenotype in order ensure optimal therapeutic efficacy. In this study, we conducted a comparative analysis 4 regimens involving single and repeated infusions human umbilical cord Wharton’s jelly-derived MSCs (hucMSCs), blood mononuclear cells (UCB), sequential hucMSCs UCB T2DM rats. Results showed all exhibited comparable efficacy lowering fasting glucose levels suppressing glucagon secretion. Single double tendency migrate liver, thereby better at ameliorating hepatic metabolism by enhancing glycogen synthesis storage, promoting glycolysis, inhibiting gluconeogenesis, improving insulin signal transduction. The demonstrated specific tropism toward pancreas, leading prolonged glucose-lowering effects following tolerance test, restoration early-phase secretion, stimulation islet beta proliferation improvement beta/alpha ratio. Multiple injections, regardless type, reduced expression systemic chronic inflammatory markers such as IL-1β, IL-6, IL-17, IL-22, IFN-γ. Finally, dose greater target visceral fat enhanced effectiveness regulating total cholesterol triglycerides. conclusion, our study provided diverse phenotypes, offering improved treatment alternatives future clinical trials applications.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12625 - 12625
Опубликована: Ноя. 25, 2024
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by autoantibody production hyper-activated B cells. Although mesenchymal stem cells (MSCs) relieve symptoms inhibiting mainly T cells, whether MSCs also inhibit has been controversial. Here, we found that naïve inhibited IFN-γ but not IgM We used chemical approach to prime ingenol-3-angelate (I3A), non-tumor-promoting phorbol ester, activated in TGF-β1-dependent manner. showed IL-1β induced continuously secrete TGF-β1, which directly whereas did not. I3A-treated were better than at ameliorating SLE MRL.
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Сен. 16, 2024
Abstract Psoriasis is an immune mediated, chronic inflammatory skin disease. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have inherent immunomodulatory potency from their parental cells, the mesenchymal cells (MSCs). In this study, we revealed application potential of MSC-EVs to alleviate psoriatic symptoms in imiquimod-induced psoriasis mouse model.
Язык: Английский
Процитировано
0