The Immunosenescence Clock: A New Method for Evaluating Biological Age and Predicting Mortality Risk DOI Creative Commons
Shuyu Li, Ke Wang, Jingni Wu

и другие.

Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102653 - 102653

Опубликована: Дек. 1, 2024

Precisely assessing an individual's immune age is critical for developing targeted aging interventions. Although traditional methods evaluating biological age, such as the use of cellular senescence markers and physiological indicators, have been widely applied, these inherently struggle to capture full complexity aging. We propose concept 'immunosenescence clock' that evaluates system changes on basis in cell abundance omics data (including transcriptome proteome data), providing a complementary indicator understanding age-related transformations. Rather than claiming definitively measure this approach can be divided into prediction clock mortality clock. The main function reflect state through peripheral blood mononuclear cells (PBMCs), whereas emphasizes ability identify people at high risk disease. hereby present nearly all immunosenescence clocks developed date, well their functional differences. Critically, we explicitly acknowledge no single diagnostic test exhaustively intricate associated with Furthermore, functions are based acceleration or delay immunosenescence, also summarize factors accelerate delaying it. A deep regulatory mechanisms help establish more accurate immune-age models, support personalized longevity interventions improving quality life old age.

Язык: Английский

Bioinformatics insights into mitochondrial and immune gene regulation in Alzheimer's disease DOI Creative Commons
Meng Tian, Yazhuo Zhang, Ye Yuan

и другие.

European journal of medical research, Год журнала: 2025, Номер 30(1)

Опубликована: Фев. 8, 2025

There is growing evidence that the pathogenesis of Alzheimer's disease closely linked to resident innate immune cells central nervous system, including microglia and astrocytes. Mitochondrial dysfunction in has also been reported play an essential role AD other neurological diseases. Therefore, finding mitochondrial immune-related gene (MIRG) signatures can be significant diagnosing treating AD. In this study, intersection differentially expressed genes (DEGs) from GSE109887 cohort, (IRGs) obtained WGCNA analysis, mitochondria-related (MRGs) was taken identify mitochondria-immune-related (MIRGs). Then, using machine learning algorithms, biomarkers with good diagnostic value were selected, a nomogram constructed. Subsequently, we further analyzed signaling pathways potential biological mechanisms through set enrichment prediction transcription factors (TFs), miRNAs, drug prediction. Using five (TSPO, HIGD1A, NDUFAB1, NT5DC3, MRPS30) successfully identified, model strong ability accuracy (AUC > 0.9) addition, single-gene analysis revealed NDUFAB1 significantly enriched associated diseases, such as Parkinson's, providing valuable insights for future clinical research on context mitochondrial-immune interactions. Interestingly, brain tissue pathology showed neuronal atrophy demyelination mice, along reduction Nissl bodies. Furthermore, escape latency mice longer than control group. After platform removal, there notable increase path complexity time required reach target quadrant, suggesting spatial memory capacity mice. Moreover, qRT-PCR validation confirmed mRNA expression consistent bioinformatics results. TSPO increased, while MRPS30 expressions decreased. However, peripheral blood samples did not show HIGD1A or MRPS30. These findings provide new interactions, exploring offering perspectives development novel drugs. Five biomarkers, i.e., TSPO, MRPS30, disease, screened by machine-learning algorithmic models, which will guide mitochondria-immunity-related direction.

Язык: Английский

Процитировано

0
Natural Killer Cells in Alzheimer's Disease: From Foe to Friend DOI
Miloš Kostić, Nikola Živković, Ana Cvetanović

и другие.

European Journal of Neuroscience, Год журнала: 2025, Номер 61(7)

Опубликована: Апрель 1, 2025

ABSTRACT The neuroinflammatory aspect of Alzheimer's disease ( AD ) has been largely focused on microglia, the innate immune cells brain; however, recent evidence increasingly points to importance multiple alterations in systemic response during development. Natural killer (NK) are also components immunity, whose role pathogenesis sporadically investigated and often conflicting results have reported. Recent clinical trial suggested potential beneficial effects immunotherapy based ex vivo–expanded, genetically unmodified, NK cells. This led increased interest understanding function these central nervous system both physiological pathological contexts such as . Considering that is predominantly a elderly population, this review, we summarized current state knowledge changes occur cell compartment normal aging process pathophysiological throughout continuum could potentially explain therapeutic efficacy

Язык: Английский

Процитировано

0
Inhibitory neuron links the causal relationship from air pollution to psychiatric disorders: a large multi-omics analysis DOI Creative Commons
Xisong Liang, Jie Wen, Chunrun Qu

и другие.

Journal Of Big Data, Год журнала: 2024, Номер 11(1)

Опубликована: Сен. 11, 2024

Язык: Английский

Процитировано

0
The Immunosenescence Clock: A New Method for Evaluating Biological Age and Predicting Mortality Risk DOI Creative Commons
Shuyu Li, Ke Wang, Jingni Wu

и другие.

Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102653 - 102653

Опубликована: Дек. 1, 2024

Precisely assessing an individual's immune age is critical for developing targeted aging interventions. Although traditional methods evaluating biological age, such as the use of cellular senescence markers and physiological indicators, have been widely applied, these inherently struggle to capture full complexity aging. We propose concept 'immunosenescence clock' that evaluates system changes on basis in cell abundance omics data (including transcriptome proteome data), providing a complementary indicator understanding age-related transformations. Rather than claiming definitively measure this approach can be divided into prediction clock mortality clock. The main function reflect state through peripheral blood mononuclear cells (PBMCs), whereas emphasizes ability identify people at high risk disease. hereby present nearly all immunosenescence clocks developed date, well their functional differences. Critically, we explicitly acknowledge no single diagnostic test exhaustively intricate associated with Furthermore, functions are based acceleration or delay immunosenescence, also summarize factors accelerate delaying it. A deep regulatory mechanisms help establish more accurate immune-age models, support personalized longevity interventions improving quality life old age.

Язык: Английский

Процитировано

0