Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Дек. 9, 2024
Colorectal cancer (CRC) is a leading cause of cancer-related deaths globally. The heterogeneity the tumor microenvironment significantly influences patient prognosis, while diversity cells shapes its unique characteristics. A comprehensive analysis molecular profile crucial for identifying novel targets drug sensitivity and uncovering pathophysiological mechanisms underlying CRC.
Язык: Английский
Discover Oncology, Год журнала: 2024, Номер 15(1)
Опубликована: Сен. 27, 2024
Язык: Английский
Процитировано
0
World Journal of Gastrointestinal Oncology, Год журнала: 2024, Номер 16(11), С. 4354 - 4368
Опубликована: Окт. 25, 2024
The relevant mechanism of tumor-associated macrophages (TAMs) in the treatment colorectal cancer patients with immune checkpoint inhibitors (ICIs) is discussed, and application prospects TAMs reversing tolerance ICIs are discussed to provide a reference for related studies. As class drugs widely used clinical tumor immunotherapy, can act on regulatory molecules cells that play an inhibitory role - checkpoints kill tumors form response by activating variety system. sensitivity different types ICI varies greatly. phenotype function microenvironment closely efficacy ICIs. regulate phenotypic TAMs, also affect therapy. important resistance, making full use this target as therapeutic strategy expected improve immunotherapy prognosis cancer.
Язык: Английский
Процитировано
0
Discover Oncology, Год журнала: 2024, Номер 15(1)
Опубликована: Ноя. 18, 2024
Autophagy is a crucial mechanism for maintaining cellular homeostasis and responding to environmental stress, it closely linked tumor drug resistance. Through multi-omics analysis, this study explores the expression patterns, functions, potential role of autophagy-related gene Angiotensinogen (AGT) in colorectal cancer (CRC), particularly relation chemotherapy This first compared AGT between CRC normal tissues using GTEx TCGA databases. Differences were assessed Wilcoxon Rank Sum Tests, prognostic impact was evaluated through univariate Cox survival analysis meta-analysis. Functional enrichment performed limma fgsea packages. Drug sensitivity conducted based on CTRP database, while immune infiltration CIBERSORT ESTIMATE methods. Spatial transcriptomic characteristics explored 10x Visium technology deconvolution investigate correlation levels cell content.scRNA-seq data from sourced Tumor Immune Single Cell Hub (TISCH).Functional annotation with Single-sample set (SSGSEA), pseudotime Monocle 2 mapped their developmental trajectories. The inhibitors treatment analyzed drug-target Mendelian randomization.Finally, Phenome-Wide Association Study (PheWAS) evaluate genetic associations side effects inhibitors. significantly higher associated shorter recurrence-free (RFS). signaling pathways markedly enriched high group. positively correlated resistance chemotherapeutic agents such as gemcitabine, cisplatin, paclitaxel, 5-fluorouracil. revealed that predominantly expressed malignant regions. Single-cell identified 21 distinct subpopulations across 13 major types. samples, especially fibroblast C6 subpopulation. Tumor-related C1, C5, C6, C8 subpopulations. Pseudotime these subpopulations, terminal stages.Drug-target randomization indicated negative causal relationship risk both heart failure(ORdrug = 0.950, 95% CI, 0.912–0.990; P 0.014) CRC(ORdrug 0.874, CI: 0.792–0.964; 0.007).PheWAS showed no other traits, indicating its specificity low effects. Elevated chemotherapy, inhibition may offer therapeutic avenue cancer.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Дек. 9, 2024
Colorectal cancer (CRC) is a leading cause of cancer-related deaths globally. The heterogeneity the tumor microenvironment significantly influences patient prognosis, while diversity cells shapes its unique characteristics. A comprehensive analysis molecular profile crucial for identifying novel targets drug sensitivity and uncovering pathophysiological mechanisms underlying CRC.
Язык: Английский
Процитировано
0