Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Март 7, 2025
Abstract
Macrophages
are
immune
cells
belonging
to
the
mononuclear
phagocyte
system.
They
play
crucial
roles
in
defense,
surveillance,
and
homeostasis.
This
review
systematically
discusses
types
of
hematopoietic
progenitors
that
give
rise
macrophages,
including
primitive
progenitors,
erythro-myeloid
stem
cells.
These
have
distinct
genetic
backgrounds
developmental
processes.
Accordingly,
macrophages
exhibit
complex
diverse
functions
body,
phagocytosis
clearance
cellular
debris,
antigen
presentation,
response,
regulation
inflammation
cytokine
production,
tissue
remodeling
repair,
multi-level
regulatory
signaling
pathways/crosstalk
involved
homeostasis
physiology.
Besides,
tumor-associated
a
key
component
TME,
exhibiting
both
anti-tumor
pro-tumor
properties.
Furthermore,
functional
status
is
closely
linked
development
various
diseases,
cancer,
autoimmune
disorders,
cardiovascular
disease,
neurodegenerative
metabolic
conditions,
trauma.
Targeting
has
emerged
as
promising
therapeutic
strategy
these
contexts.
Clinical
trials
macrophage-based
targeted
drugs,
immunotherapies,
nanoparticle-based
therapy
were
comprehensively
summarized.
Potential
challenges
future
directions
targeting
also
been
discussed.
Overall,
our
highlights
significance
this
versatile
cell
human
health
which
expected
inform
research
clinical
practice.
Язык: Английский
Subepicardial adipose genes contribute to the deterioration of heart failure preserved ejection fraction
Frontiers in Cardiovascular Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 21, 2025
The
mortality
of
patients
with
acute
myocardial
infarction
(MI)
raised
rapidly
in
last
decade
and
obesity
are
becoming
the
major
cause
to
CAD
progression,
thus
inducing
heart
failure
preserved
ejection
fraction
(HFpEF).
However,
why
visceral
adipocytes
show
different
effects
on
healthy
ageing
cardiomyocytes
is
less
known.
GSE251971
was
downloaded
Venn
diagram
between
adipocyte
genes
DEGs
performed
obtain
adipocyte-associated
failure.
Protein-protein
interaction
(PPI)
network
constructed
hub
utilizing
Cytoscape
plugin
Cytohubba.
their
interactions
were
analyzed
using
NetworkAnalyst
3.0
for
validation,
expressions
Single-cell
sequencing
data,
cell
lines
human
sub-epicardial
tissues
blood
samples.
Using
diagram,
71
identified.
Nine
obtained,
including
OGN,
SELL,
FOS,
NKG7,
LOX,
HBB,
CXCL9,
CP
ALOX5.
demonstrated
all
highly
expressed
hypertrophic
cardiomyopathy
ischemic
end-stage
related
NKG7
ALOX5
mRNA
significantly
HFpEF
patients.
AUCs
FOS
0.902,
0.795
0.730,
AUC
joint
ROC
0.946.
Additionally,
OGN
increased
at
follow
up
1
year
recurrence,
while
decreased
2
recurrence.
Mechanically,
macrophages
under
hypoxia,
fibroblasts
hypoxia.
SASPs,
IL1α,
IL1β,
IL6
TNFα,
hypoxic
after
knockdown
or
both.
Also,
SASPs
knockdown.
These
results
suggested
that
may
affect
senescence
progression.
screened
genes,
ALOX5,
validated
single-cell
samples,
which
can
be
therapeutic
targets
treatment
hypoxia
prediction
progression
HFpEF.
Язык: Английский
IL-4-Induced Gene 1: A Potential Player in Myocardial Infarction
Reviews in Cardiovascular Medicine,
Год журнала:
2024,
Номер
25(9)
Опубликована: Сен. 20, 2024
Myocardial
infarction
(MI),
a
severe
outcome
of
cardiovascular
disease,
poses
serious
threat
to
human
health.
Uncontrolled
inflammation
and
excessive
cardiomyocyte
death,
following
an
event,
significantly
contribute
both
the
mortality
rate
complications
associated
with
MI.
The
protein
IL-4-induced
gene
1
(IL4I1
or
FIG1)
serves
as
natural
inhibitor
innate
adaptive
immunity,
playing
crucial
role
in
CD4+
T
cell
differentiation,
macrophage
polarization,
ferroptosis
inhibition.
Previous
studies
have
linked
IL4I1
acute
This
review
summarizes
evidence
from
basic
clinical
research,
highlighting
critical
immunoregulatory
enzyme
that
not
only
regulates
inflammatory
responses,
but
also
potentially
mitigates
MI-induced
damage.
Язык: Английский
Exercise in ozone-polluted air evokes pathological cardiac hypertrophy via up-regulation of nuclear lncRNA EYA4-au1 and recruiting Med11 to activating EYA4/p27kip1/CK2α/HDAC2 cascade
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
287, С. 117264 - 117264
Опубликована: Окт. 31, 2024
Engaging
in
exercise
an
ozone
(O
Язык: Английский