SOX13 as a potential prognostic biomarker linked to immune infiltration and ferroptosis inhibits the proliferation, migration, and metastasis of thyroid cancer cells DOI Creative Commons

Yanyan Ma,

Weinan Zhou, Qian Yue

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Дек. 11, 2024

Background SOX13 is a transcription factor belonging to the SOX family. proteins are critical regulators of multiple cancer progression, and some known control carcinogenesis. Nevertheless, functional clinical significance in human thyroid (THCA) remain largely unelucidated. Methods Data on expression were obtained through The Cancer Genome Atlas together with Gene Expression Omnibus. Co-expression, differential expression, analyses genes investigated by databases. Associations between levels, immune infiltration, ferroptosis, checkpoint gene levels analyzed. Genetic changes using CBioPortal. THCA clinicopathological features analyzed nomogram modeling for diagnostic prognostic prediction. influence proliferation, migration, metastasis was determined KTC-1 TPC-1 cell lines. Results significantly lower tumors compared controls. In addition, upregulated mutation evident cancer. SOX13-associated exhibited pathways associated development. Significant associations found tissue. correlated stage, histologic grade, primary neoplasm focus types, independently predicted overall progression-free intervals. effectively distinguished tumor normal Spearman correlations highlighted significant relationship ferroptosis-associated genes. Overexpression enhances inhibition RSL3 (iron death activator) viability TPC-1. Higher Thyroid cells may lead reduced regulating ferroptosis. Conclusion Reduced inversely impacts patient prognosis. strongly regulates immunity Ferroptosis. Hence, has great promise as bioindicator both prognosis invasion.

Язык: Английский

SOXs: Master architects of development and versatile emulators of oncogenesis DOI

Saloni,

Manisha Sachan,

Rahul Johari

и другие.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2025, Номер unknown, С. 189295 - 189295

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Blood transcriptomic associations of epigenetic age in adolescents DOI Creative Commons
Dennis Khodasevich, Anne K. Bozack, Saher Daredia

и другие.

Epigenetics, Год журнала: 2025, Номер 20(1)

Опубликована: Май 16, 2025

Epigenetic aging in early life remains poorly characterized, and patterns of gene expression can provide biologically meaningful insights. Blood DNA methylation was measured using the Illumina EPICv1.0 array RNA sequencing performed blood 174 adolescent participants (age range: 14-15 years) from CHAMACOS cohort. Thirteen widely used epigenetic clocks were calculated, their associations with transcriptome-wide tested limma-voom pipeline. We found evidence for substantial shared between different clocks, including differential MYO6 ZBTB38 across five clocks. The epiTOC2, principal component (PC) PhenoAge, Hannum, PedBE PC Hannum associated highest number RNAs, exhibiting 22, 8, 5, 3, 2 transcripts respectively. Generally, biological more genes than chronological relative to CpG-trained counterparts. A total 17 our study replicated an independent adult sample 40-54 years). Our findings support relevance adolescents direction selection ageing biomarkers research.

Язык: Английский

Процитировано

0
SOX13 as a potential prognostic biomarker linked to immune infiltration and ferroptosis inhibits the proliferation, migration, and metastasis of thyroid cancer cells DOI Creative Commons

Yanyan Ma,

Weinan Zhou, Qian Yue

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Дек. 11, 2024

Background SOX13 is a transcription factor belonging to the SOX family. proteins are critical regulators of multiple cancer progression, and some known control carcinogenesis. Nevertheless, functional clinical significance in human thyroid (THCA) remain largely unelucidated. Methods Data on expression were obtained through The Cancer Genome Atlas together with Gene Expression Omnibus. Co-expression, differential expression, analyses genes investigated by databases. Associations between levels, immune infiltration, ferroptosis, checkpoint gene levels analyzed. Genetic changes using CBioPortal. THCA clinicopathological features analyzed nomogram modeling for diagnostic prognostic prediction. influence proliferation, migration, metastasis was determined KTC-1 TPC-1 cell lines. Results significantly lower tumors compared controls. In addition, upregulated mutation evident cancer. SOX13-associated exhibited pathways associated development. Significant associations found tissue. correlated stage, histologic grade, primary neoplasm focus types, independently predicted overall progression-free intervals. effectively distinguished tumor normal Spearman correlations highlighted significant relationship ferroptosis-associated genes. Overexpression enhances inhibition RSL3 (iron death activator) viability TPC-1. Higher Thyroid cells may lead reduced regulating ferroptosis. Conclusion Reduced inversely impacts patient prognosis. strongly regulates immunity Ferroptosis. Hence, has great promise as bioindicator both prognosis invasion.

Язык: Английский

Процитировано

1