Emerging Mechanisms and Biomarkers Associated with T-Cells and B-Cells in Autoimmune Disorders

Clinical Reviews in Allergy & Immunology, Год журнала: 2025, Номер 68(1)

Опубликована: Фев. 11, 2025

Язык: Английский

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Assessing the causal relationship between metabolic biomarkers and coronary artery disease by Mendelian randomization studies

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Авг. 16, 2024

The development of coronary artery disease (CAD) is significantly affected by impaired endocrine and metabolic status. Under this circumstance, improved prevention treatment CAD may result from knowing the connection between metabolites CAD. This study aims to delve into causal relationship human biomarkers using two-sample Mendelian randomization (MR). Utilizing bidirectional MR analysis, we assessed correlation 1400 blood CAD, data CLSA, encompassing 8299 participants. Metabolite analysis identified 1091 plasma 309 ratios as instrumental variables. To evaluate link analyzed three datasets: ebi-a-GCST005195 (547,261 European & East Asian samples), bbj-a-159 (29,319 cases 183,134 controls), ebi-a-GCST005194 (296,525 samples). estimate links, utilized IVW method. conduct sensitivity used MR-Egger, Weighted Median, MR-PRESSO. Additionally, employed MR-Egger interception Cochran's Q statistic assess potential heterogeneity pleiotropy. What's more, replication reverse analyses were performed verify reliability results order disease. Furthermore, conducted a pathway identify pathways. 59 27 metabolite nominally associated with (P < 0.05) A total four known metabolites, namely beta-hydroxyisovaleroylcarnitine (OR 1.06, 95% CI 1.027–1.094, FDR 0.07), 1-palmitoyl-2-arachidonoyl 1.07, 1.029–1.110, 0.09), 1-stearoyl-2- docosahexaenoyl 1.034–1.113, 0.07) Linoleoyl-arachidonoyl-glycerol, 1.036–1.105, 0.05), two ratios, spermidine N-acetylputrescine ratio 0.94, 0.903–0.972, 0.09) benzoate linoleoyl-arachidonoyl-glycerol 0.87, 0.879–0.962, confirmed having significant after correcting for method (p 0. 1). was found be established beta -hydroxyisovalerylcarnitine validation in other datasets. Moreover, multiple pathways discovered Our supports hypothesis that have an impact on demonstrating important new strategies

Язык: Английский

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Causal effect of vascular endothelial growth factor on the risk of atrial fibrillation: a two-sample Mendelian randomization study

Frontiers in Cardiovascular Medicine, Год журнала: 2024, Номер 11

Опубликована: Окт. 18, 2024

Observational studies have found that vascular endothelial growth factor (VEGF) levels are associated with the risk of cardiovascular disease. However, it remains unclear whether VEGF a causal effect on atrial fibrillation.

Язык: Английский

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Association Between Glaucoma and Brain Structural Connectivity Based on Diffusion Tensor Tractography: A Bidirectional Mendelian Randomization Study

Brain Sciences, Год журнала: 2024, Номер 14(10), С. 1030 - 1030

Опубликована: Окт. 17, 2024

Glaucoma is a neurodegenerative ocular disease that accompanied by cerebral damage extending beyond the visual system. Recent studies based on diffusion tensor tractography have suggested an association between glaucoma and brain structural connectivity but not clarified causality.

Язык: Английский

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