Relevance of proteomics and metabolomics approaches to overview the tumorigenesis and better management of cancer
3 Biotech,
Год журнала:
2025,
Номер
15(3)
Опубликована: Фев. 11, 2025
Язык: Английский
Reversing NK cell exhaustion: a novel strategy combining immune checkpoint blockade with drug sensitivity enhancement in the treatment of hepatocellular carcinoma
Frontiers in Oncology,
Год журнала:
2025,
Номер
14
Опубликована: Янв. 21, 2025
Hepatocellular
carcinoma
(HCC)
is
one
of
the
most
common
lethal
cancers
worldwide.
Natural
killer
cells
(NK
cells)
play
a
key
role
in
liver
immunosurveillance,
but
tumor
microenvironment,
NK
are
readily
depleted,
as
evidenced
by
down-regulation
activating
receptors,
reduced
cytokine
secretion,
and
attenuated
killing
function.
The
up-regulation
inhibitory
such
PD-1,
TIM-3,
LAG-3,
further
exacerbates
depletion
cells.
Combined
blockade
strategies
targeting
these
immunosuppressive
mechanisms,
combination
PD-1
inhibitors
with
other
pathways
(eg.
TIM-3
LAG-3),
have
shown
potential
to
reverse
cell
exhaustion
preclinical
studies.
This
article
explores
promise
innovative
HCC
immunotherapy,
providing
new
therapeutic
directions
for
optimizing
function
improving
drug
sensitivity.
Язык: Английский
A single-cell perspective on immunotherapy for pancreatic cancer: from microenvironment analysis to therapeutic strategy innovation
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 30, 2024
Pancreatic
cancer
remains
one
of
the
most
lethal
malignancies,
with
conventional
treatment
options
providing
limited
efficacy.
Recent
advancements
in
immunotherapy
have
offered
new
hope,
yet
unique
tumor
microenvironment
(TME)
pancreatic
poses
significant
challenges
to
its
successful
application.
This
review
explores
transformative
impact
single-cell
technology
on
understanding
and
cancer.
By
enabling
high-resolution
analysis
cellular
heterogeneity
within
TME,
approaches
elucidated
complex
interplay
between
various
immune
cell
populations.
These
insights
led
identification
predictive
biomarkers
development
innovative,
personalized
immunotherapeutic
strategies.
The
discusses
role
dissecting
intricate
landscape
cancer,
highlighting
discovery
T
exhaustion
profiles
macrophage
polarization
states
that
influence
response.
Moreover,
it
outlines
potential
data
guiding
selection
drugs
optimizing
plans.
also
addresses
prospects
translating
these
single-cell-based
innovations
into
clinical
practice,
emphasizing
need
for
interdisciplinary
research
integration
artificial
intelligence
overcome
current
limitations.
Ultimately,
underscores
promise
driving
therapeutic
strategy
innovation
improving
patient
outcomes
battle
against
Язык: Английский
Mitochondria: a crucial factor in the progression and drug resistance of colorectal cancer
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 23, 2024
Colorectal
cancer
(CRC),
as
one
of
the
malignant
tumors
with
highest
incidence
and
mortality
rates
worldwide
in
recent
years,
originating
primarily
from
mucosal
tissues
colon
or
rectum,
has
potential
to
rapidly
develop
into
invasive
cancer.
Its
pathogenesis
is
complex,
involving
a
multitude
factors
including
genetic
background,
lifestyle,
dietary
habits.
Early
detection
treatment
are
key
improving
survival
for
patients
CRC.
However,
pervasive
problem
that
can
become
severely
resistant
treatment,
which
greatly
increases
complexity
challenge
treatment.
Therefore,
unraveling
overcoming
resistance
CRC
focus
research.
Mitochondria,
energy
centers
cell,
play
crucial
role
cellular
metabolism,
supply,
apoptosis
process.
In
CRC,
Mitochondrial
dysfunction
not
only
impairs
normal
cell
function
but
also
promotes
tumor
resistance.
deep
understanding
relationship
between
mitochondrial
mechanisms
development,
well
by
it
chemotherapy
drugs,
development
targeted
therapies,
enhancing
drug
efficacy,
outcomes
quality
life
patients.
Язык: Английский
Targeting the CSF1/CSF1R signaling pathway: an innovative strategy for ultrasound combined with macrophage exhaustion in pancreatic cancer therapy
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 2, 2024
Pancreatic
cancer
(PC)
is
a
highly
aggressive
and
lethal
malignancy
characterized
by
complex
tumor
microenvironment
(TME)
immunosuppressive
features
that
limit
the
efficacy
of
existing
treatments.
This
paper
reviews
potential
combining
ultrasound
with
macrophage
exhaustion
in
treatment
pancreatic
cancer.
Macrophages,
particularly
tumor-associated
macrophages
(TAMs),
are
crucial
progression
immune
escape.
Prolonged
exposure
to
TME
leads
exhaustion,
reducing
their
anti-tumor
ability
instead
promoting
growth.
The
CSF1/CSF1R
signaling
pathway
key
recruitment
functional
regulation,
making
it
an
effective
target
for
combating
exhaustion.
Ultrasound
technology
not
only
plays
significant
role
diagnosis
staging
but
also
enhances
therapeutic
guiding
radiofrequency
ablation
(RFA)
percutaneous
alcohol
injection
(PEI)
combination
immunomodulators.
Additionally,
imaging
can
monitor
number
status
TAMs
real-time,
providing
basis
optimizing
strategies.
Future
studies
should
further
investigate
combined
use
immunomodulators
refine
regimens,
address
challenges
such
as
individual
variability
long-term
effects,
offer
new
hope
patients.
Язык: Английский
Deciphering the role of NcRNAs in Pancreatic Cancer immune evasion and drug resistance: a new perspective for targeted therapy
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 1, 2024
Pancreatic
cancer
(PC)
is
a
very
aggressive
digestive
system
tumor,
known
for
its
high
mortality
rate,
low
cure
survival
rate
and
poor
prognosis.
In
particular,
pancreatic
ductal
adenocarcinoma
(PADC),
which
accounts
more
than
90%
of
PC
cases,
has
an
overall
5-year
only
5%,
extremely
critical
situation.
Early
detection
effective
treatment
difficult,
leads
many
patients
to
despair.
the
current
medical
context,
targeted
therapy,
as
important
strategy
treatment,
expected.
However,
problems
immune
escape
drug
resistance
in
have
become
two
major
obstacles
that
are
difficult
be
overcome
by
therapy.
How
break
through
these
difficulties
key
issue
solved
field
recent
years,
non-coding
RNAs
(ncRNAs)
continued
heat
up
research.
NcRNAs
play
pivotal
role
gene
regulation,
cell
differentiation,
development,
disease
processes,
their
roles
genesis,
therapeutic
response
been
gradually
revealed.
More
importantly,
ncRNAs
advantages
targets,
such
specificity
side
effects,
making
them
new
favorite
Therefore,
aim
this
paper
provide
ideas
methods
therapy
reviewing
mechanism
action
four
(circRNAs,
lncRNAs,
miRNAs,
siRNAs)
both
PC.
It
expected
way
can
found
in-depth
study
ncRNA,
bringing
ray
hope
patients.
Язык: Английский