Biology, Год журнала: 2024, Номер 13(11), С. 898 - 898
Опубликована: Ноя. 4, 2024
There exists a long-standing research interest to understand the molecular and signaling interactions between tumor cells innate adaptive immune such as dendritic cells, macrophages, NK B T that occur in microenvironment (TME) [...]
Язык: Английский
Biology, Год журнала: 2024, Номер 13(5), С. 307 - 307
Опубликована: Апрель 28, 2024
Cancer immune evasion represents a leading hallmark of cancer, posing significant obstacle to the development successful anticancer therapies. However, landscape cancer treatment has significantly evolved, transitioning into era immunotherapy from conventional methods such as surgical resection, radiotherapy, chemotherapy, and targeted drug therapy. Immunotherapy emerged pivotal component in treatment, harnessing body’s system combat offering improved prognostic outcomes for numerous patients. The remarkable success spurred efforts enhance clinical efficacy existing agents strategies. Several immunotherapeutic approaches have received approval treatments, while others are currently preclinical trials. This review explores recent progress unraveling mechanisms evaluates effectiveness diverse strategies, including vaccines, adoptive cell therapy, antibody-based treatments. It encompasses both established treatments those under investigation, providing comprehensive overview through immunological approaches. Additionally, article emphasizes current developments, limitations, challenges immunotherapy. Furthermore, by integrating analyses resistance exploring combination strategies personalized approaches, it offers valuable insights crucial novel
Язык: Английский
Процитировано
9
International review of cell and molecular biology, Год журнала: 2025, Номер unknown, С. xiii - xvii
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Current Opinion in Cell Biology, Год журнала: 2024, Номер 90, С. 102422 - 102422
Опубликована: Авг. 30, 2024
Many solid tumors exhibit significant genetic, cellular, and biophysical heterogeneity which dynamically evolves during disease progression after treatment. This constant flux in cell composition, phenotype, spatial relationships, tissue properties poses challenges accurately diagnosing treating patients. Much of the complexity lies unraveling molecular changes different tumor compartments, how they influence one another space time where vulnerabilities exist that might be appropriate to target therapeutically. Recent advances profiling tools technologies are enabling new insight into underlying biology complex tumors, creating a greater understanding intricate relationship between types, states, microenvironment. Here we reflect on some recent discoveries this area, key knowledge technology gaps lie, advancements measurements vitro models for study intratumoral heterogeneity.
Язык: Английский
Процитировано
2
International review of cell and molecular biology, Год журнала: 2024, Номер unknown, С. 67 - 103
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
1
Biology, Год журнала: 2024, Номер 13(11), С. 898 - 898
Опубликована: Ноя. 4, 2024
There exists a long-standing research interest to understand the molecular and signaling interactions between tumor cells innate adaptive immune such as dendritic cells, macrophages, NK B T that occur in microenvironment (TME) [...]
Язык: Английский
Процитировано
1