Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 11, 2024
Pompe
disease,
a
severe
lysosomal
storage
disorder,
is
marked
by
heart
problems,
muscle
weakness,
and
respiratory
difficulties.
This
study
aimed
to
identify
novel
markers
for
infantile-onset
disease
analyzing
key
genes
immune
cells
infiltrating
affected
skeletal
muscles,
building
on
existing
research
linking
its
progression
the
cell
infiltration.
The
datasets
GSE38680
GSE159062
were
downloaded
differential
expression
(DEGs)
identified.
Potential
screened
using
support
vector
machine
recursive
feature
elimination
(SVM-RFE)
analysis
least
absolute
shrinkage
selection
operator
(LASSO)
regression
models.
To
analyze
DEGs
processes,
22
types
in
tissues
examined
CIBERSORT.
Kyoto
Encyclopedia
of
Genes
Genomes
(KEGG)
pathway
revealed
significant
enrichment
calcium
signaling
pathway,
phosphatidylinositol
system,
ubiquitin-mediated
proteolysis
JAK-STAT
pathway.
Machine
learning
identified
GPNMB,
CALML6
TRIM7
as
genes.
Immune
infiltration
showed
that
levels
above
three
closely
related
our
target
population
under
study,
including
T
regulatory
(Tregs),
monocytes,
macrophages
M0,
resting
activated
dendritic
cells,
naive
memory
B
cells.
Overall,
results
may
provide
new
clues
exploring
highlighting
their
relationship
with
infiltration,
offering
insights
into
disease's
development.
However,
previous
studies
have
shown
limited
evidence
biopsies
from
patients,
this
lack
direct
necessitates
further
investigation
experimental
validation
laboratory
settings
confirm
these
associations.
Antioxidants,
Год журнала:
2025,
Номер
14(2), С. 150 - 150
Опубликована: Янв. 27, 2025
Obesity
results
from
a
disproportionate
accumulation
of
fat
and
has
become
global
health
concern.
The
increase
in
adipose
tissue
is
responsible
for
several
systemic
testicular
changes
including
hormone
levels
(leptin,
adiponectin,
testosterone,
estrogen),
inflammatory
cytokines
(increase
TNF-α
IL-6
decrease
IL-10),
redox
state
reactive
oxygen
species
reduction
antioxidant
enzymes).
This
poor
sperm
quality
compromised
fertility
men
with
obesity.
Lifestyle
modifications,
particularly
diet
transition
to
caloric
restriction
physical
exercise,
are
reported
reverse
these
negative
effects.
Nevertheless,
precise
mechanisms
mediating
benefits,
how
they
modulate
oxidative
stress,
inflammation,
metabolism,
remain
be
fully
elucidated.
main
pathway
described
by
which
lifestyle
interventions
obesity-induced
damage
the
Nrf2-SIRT1
axis,
modulates
overexpression
defenses.
Of
note,
some
detrimental
effects
obesity
on
testis
inherited
descendants
individuals
obesity,
while
reverses
effects,
no
significant
work
been
carried
out
regarding
exercise.
review
discusses
consequences
stress
adult
pediatric
populations,
emphasizing
therapeutic
potential
mitigate
Metabolic
disorders,
including
obesity,
dyslipidemia,
diabetes,
nonalcoholic
fatty
liver
disease,
and
metabolic
syndrome,
are
characterized
by
insulin
resistance,
abnormalities
in
circulating
cholesterol
lipid
profiles,
hypertension.
The
most
common
pathophysiologies
of
disorders
glucose/lipid
metabolism
dysregulation,
inflammatory
response,
oxidative
stress.
Although
several
agents
have
been
approved
for
the
treatment
there
is
still
a
strong
demand
more
efficacious
drugs
with
less
side
effects.
Natural
products
critical
sources
drug
research
discovery
decades.
However,
usefulness
bioactive
natural
often
limited
incomplete
understanding
their
direct
cellular
targets.
In
this
review,
we
highlight
current
established
emerging
molecular
mechanisms
disorders.
We
further
summarize
therapeutic
effects
underlying
on
highlights
targets,
which
mainly
implicated
regulation
metabolism,
inflammation,
Finally,
review
also
covers
clinical
studies
These
progresses
expected
to
facilitate
application
these
derivatives
development
novel
against
Experimental and Clinical Gastroenterology,
Год журнала:
2025,
Номер
8, С. 76 - 88
Опубликована: Фев. 3, 2025
Sarcopenic
obesity
is
a
complex
condition
characterized
by
combination
of
and
sarcopenia.
This
pathology
has
significant
impact
on
the
health
quality
life
elderly
old
people,
increasing
risk
chronic
diseases
impairing
physical
functions.
Nutritional
status
plays
key
role
in
maintaining
functional
ability
older
influencing
development
sarcopenia
obesity.
Understanding
relationship
between
sarcopenic
nutritional
critical
for
developing
prevention
treatment
strategies.
Our
scientific
article
covers
various
mechanisms
influence
obesity,
also
examines
nutrients
dietary
supplements
management
this
condition.
highlights
need
comprehensive
approach
to
among
patients
improve
overall
life.
Diabetes Obesity and Metabolism,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
Abstract
Aims
GZR18,
a
novel
long‐acting
GLP‐1
receptor
agonist,
has
demonstrated
substantial
metabolic
improvements
in
diabetic
and
obese
animal
models.
The
present
studies
aimed
to
evaluate
the
safety,
tolerability,
pharmacokinetics
(PK)
pharmacodynamics
(PD)
of
ascending
dose
GZR18
healthy
American
Chinese
subjects.
Materials
Methods
In
these
phases
1,
randomized,
double‐blind,
placebo‐controlled,
sequential,
dose‐escalation
US
studies,
adults
with
similar
age
were
enrolled
once‐weekly
subcutaneous
injection
or
placebo.
included
three
cohorts
male
subjects
(cohorts
US‐1–3)
six
CN‐1–6,
female),
each
specified
target
ranging
from
1
50
μg/kg
(1–10
for
study
5–50
study).
primary
endpoints
safety
tolerability
GZR18.
Blood
samples
collected
PK
PD
analysis
before
after
dosing.
A
population
was
conducted
ascertain
whether
there
are
ethnic
differences
between
adults.
Results
exposure
comparable
subjects,
geometric
mean
ratio
two
populations
AUC
0‐t
C
max
close
1.
dose‐dependent
increase
0–t
occurred
both
populations.
median
time
maximum
plasma
concentrations
(
T
)
ranged
72
96
h,
60
h
half‐life
approximately
7
days
Evident
body
weight
reduction
observed
treatment
groups
CN‐3–6
on
Day
15,
−1.25
−1.86
kg;
−1.88%
−3.11%).
No
deaths,
serious
adverse
events
hypoglycaemia
reported.
Decreased
appetite
nausea
most
frequently
reported
treatment‐emergent
events,
mild
severity.
profile
generally
consistent
same
class
drugs.
Conclusions
demonstrates
good
profiles
support
its
further
clinical
evaluation
glycaemic
control.
Journal of Food Science,
Год журнала:
2024,
Номер
89(9), С. 5967 - 5979
Опубликована: Июль 31, 2024
Abstract
Fumonisin
B
1
(FB
)
is
a
mycotoxin
affecting
animal
health
through
the
food
chain
and
has
been
closely
associated
with
several
diseases
such
as
pulmonary
edema
in
pigs
diarrhea
poultry.
FB
mainly
metabolized
liver.
Although
few
studies
have
shown
that
causes
liver
damage,
molecular
mechanism
of
damage
unclear.
This
study
aimed
to
evaluate
role
nuclear
xenobiotic
receptor
(NXR)
response
cytochrome
P450
(CYP450)‐mediated
defense
during
exposure.
A
total
120
young
quails
were
equally
divided
into
two
groups
(control
groups).
The
control
group
fed
on
normal
diet,
while
those
quail
diet
containing
30
mg/kg
for
42
days.
Histopathological
ultrastructural
changes
liver,
biochemical
parameters,
inflammatory
factors,
endoplasmic
reticulum
(ER)
NXR
CYP450
cluster
system
other
related
genes
examined
at
14
days,
28
days
results
showed
exposure
impaired
metabolic
function
caused
injury.
ER
stress
decreased
adenosine
triphosphatease
activity,
induced
expression
inflammation‐related
interleukin
6
factor
kappa‐B,
promoted
inflammation.
In
addition,
disrupted
multiple
isoforms
by
activating
receptors
(NXRs).
present
confirms
disturbs
homeostasis
systems
(CYP450s)
responses
thereby
causing
damage.
study's
findings
provide
insight
mechanisms
‐induced
hepatotoxicity.
