Overview of Oxidative Stress in Systemic Lupus Erythematosus
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 303 - 303
Опубликована: Март 1, 2025
Systemic
lupus
erythematosus
(SLE)
is
an
autoimmune
disease
that
frequently
diagnosed
in
female
patients,
caused
by
multiple
interacting
factors.
It
has
a
complex
pathogenesis
which
can
affect
almost
any
organ,
from
the
kidneys
to
cardiovascular,
pulmonary,
neurological,
osteoarticular,
and
hematological
systems.
The
present
narrative
review
seeks
elucidate
role
of
reactive
oxygen
species
(ROS)
SLE.
central
question
guiding
this
study
what
extent
these
serum
protein
modifications
correlate
with
activity
organ
damage
characterized
decreased
apoptosis
increased
necrosis
T
cells
NETosis
granulocytes.
Given
impact
SLE
diagnosis
on
one's
life,
aims
evaluate
intricacies
oxidative
stress
its
relevance
treatment
disease.
Topics
such
as
understanding
processes
stress,
their
damaging
pathways,
biomarkers,
future
assistance
clinical
decisions
will
be
discussed
article.
accurate
determination
biomarkers
taught
improve
both
management
disease,
while
antioxidant
therapy
may
open
new
door
for
treatment.
Язык: Английский
Challenging directions in pediatric diabetes - the place of oxidative stress and antioxidants in systemic decline
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 18, 2024
Diabetes
is
a
complex
condition
with
rising
global
incidence,
and
its
impact
equally
evident
in
pediatric
practice.
Regardless
of
whether
we
are
dealing
type
1
or
2
diabetes,
the
development
complications
following
onset
disease
inevitable.
Consequently,
contemporary
medicine
must
concentrate
on
understanding
pathophysiological
mechanisms
driving
systemic
decline
finding
ways
to
address
them.
We
particularly
interested
effects
oxidative
stress
target
cells
organs,
such
as
pancreatic
islets,
retina,
kidneys,
neurological
cardiovascular
systems.
Our
goal
explore,
using
latest
data
from
international
scientific
databases,
relationship
between
persistence
damage
associated
diabetes
children.
Additionally,
highlight
beneficial
roles
antioxidants
vitamins,
minerals,
polyphenols,
other
bioactive
molecules;
mitigating
pathogenic
cascade,
detailing
how
they
intervene
their
properties.
As
result,
our
study
provides
comprehensive
exploration
key
aspects
stress-antioxidants-pediatric
triad,
expanding
significance
various
diseases.
Язык: Английский
Manifestações clínicas, comorbidades e abordagens terapêuticas da doença celíaca na pediatria: Uma revisão sistemática
Glaucia Mangili Lara,
Maria Eugênia Alves Martins de Araújo,
Maria Júlia Faria Forti
и другие.
LUMEN ET VIRTUS,
Год журнала:
2024,
Номер
15(39), С. 3079 - 3092
Опубликована: Сен. 2, 2024
Objective:
The
general
objective
of
the
present
study
is
to
analyze
scientific
production
on
Celiac
Disease,
seeking
identify
main
clinical
manifestations,
as
well
comorbidities
and
methods
used
in
treatment
this
pathology.
Methodology:
It
a
systematic
review
focused
understanding
aspects
Disease.
research
was
guided
by
question:
"What
are
associated
diseases
management
celiac
disease
pediatric
patients,
based
evidence
available
literature?".
To
find
answers,
searches
were
performed
PubMed
database
using
three
descriptors
combined
with
Boolean
term
"AND".
This
resulted
268
articles.
17
articles
selected
compose
collection.
Results:
Disease
(CD)
an
immune-mediated
condition
that
affects
gastrointestinal
tract
can
cause
several
symptoms,
including
extraintestinal
manifestations.
Diagnosis
involves
serological
testing
biopsies,
gluten
removal
being
only
effective
treatment.
Strict
adherence
gluten-free
diet
crucial
for
recovery,
but
it
vary
between
impacting
long-term
health.
Conclusion:
CD
other
autoimmune
genetic
conditions,
requiring
regular
monitoring
ongoing
support
ensure
well-being
patients.
Язык: Английский
Celiac disease in the aspect of comorbidity: facets and boundaries
Experimental and Clinical Gastroenterology,
Год журнала:
2024,
Номер
6, С. 163 - 168
Опубликована: Окт. 22, 2024
Celiac
disease
poses
a
serious
diagnostic
problem
due
to
significant
clinical
polymorphism
with
high
frequency
of
atypical
forms.
The
comorbidity
for
celiac
is
relevant
the
possible
involvement
almost
all
organs
and
systems
in
pathological
process.
In
this
regard,
question
arises
which
symptoms
are
manifestation
disease,
complications,
associated
comorbid
conditions.
obviously
damage
many
disease.
They
have
common
starting
point
-
an
immunopathological
process
leading
malabsorption
secondary
metabolic
disorders,
essentially
but
not
as
sometimes
interpreted.
A
complication
can
be
considered
oncological
consequences
develop
after
prolonged
non-compliance
gluten-free
diet.
combination
diseases,
primarily
autoimmune
should
comorbidity.
Язык: Английский
Metabolic syndrome therapy in pediatric age — between classic and modern. From diets to pipeline drugs
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Дек. 11, 2024
The
metabolic
syndrome,
made
up
of
the
sum
entities
that
define
it
(obesity,
hypertension,
dyslipidemias
and
non-alcoholic
hepatic
steatosis)
has
gained
an
important
place
in
research
last
decades.
This
aspect
is
mainly
due
to
complexity
management
pediatric
practice.
main
directions
his
approach
therefore
bring
together
concern
counteracting
noise
or
systemic,
multiple
intercurrents
at
physiopathological
level,
as
well
negative
imprint
exerted
on
quality
life.
Its
appearance
evolution
are
currently
controversial
topics,
but
influence
genetic
predisposition
lifestyle
(diet,
physical
activity,
psychological
balance)
certainties.
Considering
escalation
incident
global
self-evident
necessary
know
pathogenesis
practice
countermeasures
for
prophylactic
therapeutic
purposes.
present
work
aims
summarize
general
aspects
related
syndrome
encountered
age,
with
emphasis
complementary
perspectives
their
effectiveness,
by
analyzing
latest
data
from
specialized
literature,
accessed
help
international
databases
(e.g.,
PubMed,
Web
Science,
Scopus,
Embase,
Google
Scholar).
Язык: Английский
Assessing the Impact of Early Nutritional Intervention on Pediatric Celiac Disease Management: A Prospective Cohort Study
Cureus,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
Celiac
disease
is
a
chronic
autoimmune
condition
requiring
lifelong
adherence
to
gluten-free
diet,
particularly
in
children,
prevent
nutritional
deficiencies
and
developmental
delays.
The
objective
of
study
was
evaluate
the
effects
early
intervention
on
management
health
outcomes
children
diagnosed
with
celiac
disease.
A
prospective,
longitudinal
cohort
conducted
over
two
years
(July
2019-July
2021).
customized
meal
plan
any
necessary
dietary
supplements
were
given
participants.
Baseline
evaluations
six-monthly
follow-ups
used
gather
data
growth,
status,
compliance.
SPSS
for
statistical
analysis,
significance
threshold
p<0.05
established.
Significant
improvements
observed
growth
metrics,
mean
height
increasing
from
145.67
cm
157.48
weight
36.29
kg
46.24
24
months
(p
<
0.001).
Nutritional
status
also
improved,
serum
iron
levels
rising
45.19
µg/dL
76.89
vitamin
D
20.14
ng/mL
44.22
Dietary
increased
84.37%
94.62%.
Growth
results
are
greatly
improved
intervention.
Язык: Английский
PEDIATRIC ENTEROCOLITIS: CLINICAL MANIFESTATIONS AND MANAGEMENT STRATEGIES
Опубликована: Дек. 20, 2024
Diarrhea
is
a
leading
cause
of
illness
and
death
in
children
under
five
years
old.
Severe
cases
diarrhea,
particularly
those
resulting
dehydration,
are
major
factor
high
mortality
rates.
Rotavirus
significant
pathogen
contributing
to
dehydrating
diarrhea
hospitalizations
five.
The
aim
this
study
was
investigate
the
role
vaccination
preventing
progression
gastroenteritis,
with
focus
on
rotavirus-induced
gastroenteritis.
Material
methods:
present
conducted
within
Pediatric
Department
Emergency
Clinical
Hospital
“St.
Apostle
Andrew”
Constanța,
including
307
patients
diagnosed
acute
gastroenteritis
during
period
January
1
December
31,
2023.
Results:
prevalence
declined
age:
183
infants,
67
were
between
3
old,
42
aged
7,
smallest
group,
15
patients,
7
16
201
did
not
receive
Rotarix
or
Rotateq
vaccines,
while
106
completed
full
regimen.
As
for
etiology
disease,
160
viral
enterocolitis,
142
attributed
Rotavirus.
An
increase
dehydration
electrolyte
imbalances
observed
subjects
who
had
received
preventive
vaccine.
Conclusion:
vaccine
severe
that
caused
by
Rotavirus,
highlighted
reduced
frequency
imbalances,
shorter
hospital
stays
Rotarix/Rotateq
Язык: Английский