Oxidative Stress and Antioxidants in Pediatric Asthma’s Evolution and Management
Antioxidants,
Год журнала:
2024,
Номер
13(11), С. 1331 - 1331
Опубликована: Окт. 31, 2024
Within
the
pediatric
population,
bronchial
asthma
is
one
of
most
prevalent
chronic
respiratory
system
diseases.
The
number
exacerbations,
severity,
and
duration
symptoms
all
have
a
significant
impact
on
children's
life
quality.
In
last
decades,
prevention
management
strategies
this
pathology
focused
maintaining
or
even
increasing
pulmonary
function
to
maximum
levels
in
early
childhood,
as
it
has
been
demonstrated
that
functional
deficits
at
level
occurring
before
school
age
cause
pathological
manifestations
later,
adulthood.
epithelium
airways
implicitly
lung
first
barrier
against
lesions
caused
by
pro-oxidative
factors.
Both
oxidative
antioxidative
factors
can
be
endogenous
origin
(produced
body)
exogenous
(from
environment
diet).
Good
functioning
antioxidant
defense
mechanisms
from
molecular
tissue
level,
balance
between
anti-
factors,
influence
occurrence
compensatory
epithelium,
causing
delay
local
responses
stress
induced
inflammation
(bronchial
remodeling,
thickening
airway
smooth
muscles,
bronchoconstriction,
hyper-reactivity).
These
underlie
pathophysiological
changes
asthma.
Numerous
studies
carried
out
among
population
inclusively
effectiveness
antioxidants
prophylaxis,
slowing
down
preventing
progression
pathology.
This
review
complements
scientific
articles,
aiming
emphasizing
complexity
physio-pathological
pathways
their
importance
occurrence,
development,
therapeutic
response
asthma,
providing
good
understanding
relationship
being
source
future
strategies.
Язык: Английский
Comparative Study of Oxidative Stress Responses in Pediatric Type 1 Diabetes and Transient Hyperglycemia
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1701 - 1701
Опубликована: Фев. 17, 2025
Hyperglycemia
significantly
initiates
oxidative
stress
in
children
diagnosed
with
type
1
diabetes
(T1DM).
This
study
investigates
the
differences
markers
between
pediatric
patients
T1DM
and
those
experiencing
transient
hyperglycemia.
In
this
case-control
study,
42
T1DM,
according
to
ISPAD
(International
Society
for
Pediatric
Adolescent
Diabetes),
their
healthy
counterparts,
aged
1-6
years
old,
participated.
Blood
samples
were
analyzed
biomarkers
such
as
malondialdehyde
(MDA)
glutathione
peroxidase
(GPx).
There
was
no
statistically
significant
association
found
A1c
%
age,
BMI,
insulin
dose
(p
>
0.05).
A
negative
correlation
Se,
Zn,
cholesterol,
GSH,
GPx
<
0.05),
well
a
meaningful
positive
0.001).
GSH
exhibited
0.001)
diabetic
group.
comparison
control
participants,
plasma
MDA
levels
(1.3
±
0.36
µmol/L)
had
already
increased
significantly.
did
correlate
group
triglyceride
0.0001)
or
total
cholesterol.
group,
cholesterol
normal
apparently
not
influence
levels.
The
state
remained
unchanged
participants
temporary
hyperglycemia,
even
though
altered
link
selenium,
zinc,
lipids.
Язык: Английский
Therapeutic prospects and potential mechanisms of Prdx6: as a novel target in musculoskeletal disorders
Frontiers in Physiology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 17, 2025
With
the
global
population
aging,
musculoskeletal
disorders
(MSDs)
have
posed
significant
physical
and
psychological
health
challenges
for
patients
as
well
a
substantial
economic
burden
on
society.
The
advancements
in
conservative
surgical
interventions
MSDs
been
remarkable
recent
years;
however,
current
treatment
modalities
still
fall
short
of
meeting
optimal
requirements
patients.
Recently,
peroxiredoxin
6
(Prdx6)
has
gained
considerable
attention
from
researchers
due
to
its
antioxidative,
anti-inflammatory,
anti-apoptotic
properties.
It
found
that
Prdx6
is
involved
multiple
system
diseases,
including
MSDs;
exact
role
lacking.
This
study
aimed
summarize
structure,
regulatory
mechanism,
potential
function
Prdx6.
These
findings
may
demonstrate
novel
target
inhibiting
advancement
MSDs.
Язык: Английский
Challenging directions in pediatric diabetes - the place of oxidative stress and antioxidants in systemic decline
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 18, 2024
Diabetes
is
a
complex
condition
with
rising
global
incidence,
and
its
impact
equally
evident
in
pediatric
practice.
Regardless
of
whether
we
are
dealing
type
1
or
2
diabetes,
the
development
complications
following
onset
disease
inevitable.
Consequently,
contemporary
medicine
must
concentrate
on
understanding
pathophysiological
mechanisms
driving
systemic
decline
finding
ways
to
address
them.
We
particularly
interested
effects
oxidative
stress
target
cells
organs,
such
as
pancreatic
islets,
retina,
kidneys,
neurological
cardiovascular
systems.
Our
goal
explore,
using
latest
data
from
international
scientific
databases,
relationship
between
persistence
damage
associated
diabetes
children.
Additionally,
highlight
beneficial
roles
antioxidants
vitamins,
minerals,
polyphenols,
other
bioactive
molecules;
mitigating
pathogenic
cascade,
detailing
how
they
intervene
their
properties.
As
result,
our
study
provides
comprehensive
exploration
key
aspects
stress-antioxidants-pediatric
triad,
expanding
significance
various
diseases.
Язык: Английский
PEDIATRIC ENTEROCOLITIS: CLINICAL MANIFESTATIONS AND MANAGEMENT STRATEGIES
Опубликована: Дек. 20, 2024
Diarrhea
is
a
leading
cause
of
illness
and
death
in
children
under
five
years
old.
Severe
cases
diarrhea,
particularly
those
resulting
dehydration,
are
major
factor
high
mortality
rates.
Rotavirus
significant
pathogen
contributing
to
dehydrating
diarrhea
hospitalizations
five.
The
aim
this
study
was
investigate
the
role
vaccination
preventing
progression
gastroenteritis,
with
focus
on
rotavirus-induced
gastroenteritis.
Material
methods:
present
conducted
within
Pediatric
Department
Emergency
Clinical
Hospital
“St.
Apostle
Andrew”
Constanța,
including
307
patients
diagnosed
acute
gastroenteritis
during
period
January
1
December
31,
2023.
Results:
prevalence
declined
age:
183
infants,
67
were
between
3
old,
42
aged
7,
smallest
group,
15
patients,
7
16
201
did
not
receive
Rotarix
or
Rotateq
vaccines,
while
106
completed
full
regimen.
As
for
etiology
disease,
160
viral
enterocolitis,
142
attributed
Rotavirus.
An
increase
dehydration
electrolyte
imbalances
observed
subjects
who
had
received
preventive
vaccine.
Conclusion:
vaccine
severe
that
caused
by
Rotavirus,
highlighted
reduced
frequency
imbalances,
shorter
hospital
stays
Rotarix/Rotateq
Язык: Английский
Metabolic syndrome therapy in pediatric age — between classic and modern. From diets to pipeline drugs
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Дек. 11, 2024
The
metabolic
syndrome,
made
up
of
the
sum
entities
that
define
it
(obesity,
hypertension,
dyslipidemias
and
non-alcoholic
hepatic
steatosis)
has
gained
an
important
place
in
research
last
decades.
This
aspect
is
mainly
due
to
complexity
management
pediatric
practice.
main
directions
his
approach
therefore
bring
together
concern
counteracting
noise
or
systemic,
multiple
intercurrents
at
physiopathological
level,
as
well
negative
imprint
exerted
on
quality
life.
Its
appearance
evolution
are
currently
controversial
topics,
but
influence
genetic
predisposition
lifestyle
(diet,
physical
activity,
psychological
balance)
certainties.
Considering
escalation
incident
global
self-evident
necessary
know
pathogenesis
practice
countermeasures
for
prophylactic
therapeutic
purposes.
present
work
aims
summarize
general
aspects
related
syndrome
encountered
age,
with
emphasis
complementary
perspectives
their
effectiveness,
by
analyzing
latest
data
from
specialized
literature,
accessed
help
international
databases
(e.g.,
PubMed,
Web
Science,
Scopus,
Embase,
Google
Scholar).
Язык: Английский
Gut-brain axis as a bridge in obesity and depression: Mechanistic exploration and therapeutic prospects
World Journal of Psychiatry,
Год журнала:
2024,
Номер
15(1)
Опубликована: Дек. 18, 2024
A
recent
study
by
Wang
et
al,
published
in
the
World
Journal
of
Psychiatry,
provided
preventative
and
therapeutic
strategies
for
comorbidity
obesity
depression.
The
gut-brain
axis,
which
acts
as
a
two-way
communication
system
between
gastrointestinal
tract
central
nervous
system,
plays
pivotal
role
pathogenesis
these
conditions.
Evidence
suggests
that
metabolic
byproducts,
such
short-chain
fatty
acids,
lipopolysaccharide
bile
are
generated
gut
microbiota,
along
with
neurotransmitters
inflammatory
mediators
within
modulate
host's
processes,
neuronal
regulation,
immune
responses
through
diverse
mechanisms.
interaction
depression
via
axis
involves
disruptions
microbiota
balance,
responses,
alterations
neuroendocrine
system.
Modulating
example,
ketogenic
diet,
use
probiotics,
supplementation
antioxidants,
offers
new
remedial
approaches
Future
research
explores
mechanisms
is
needed
to
provide
more
evidence
clinical
treatment.
Язык: Английский