Medical Herald of the South of Russia,
Год журнала:
2024,
Номер
15(4), С. 90 - 98
Опубликована: Окт. 17, 2024
The
presented
literature
review
allows
us
to
understand
and
supplement
the
existing
ideas
about
pathogenesis
of
coronary
calcification
aortic
valve
at
stage
formation
these
changes.
To
study
in
detail
participation
most
studied
immunocompetent
cells
innate
immunity,
such
as
macrophages,
dendritic
mast
cells,
neutrophils,
natural
killers
arteries
valve,
their
functional
role
progression
this
process.
also
presents
gaps
missing
data
present
cell
populations,
replenishment
which
will
contribute
development
targeted
therapy
for
search
sources
was
conducted
following
databases:
Scopus,
web
Science,
MedLine,
Cochrane
Library,
RSCI,
Springer,
Science
Direct
—
taking
into
account
year
publication
(no
more
than
10
years),
language
(English/Russian),
availability
full-text
publications
access
them.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Июнь 2, 2025
Objective
This
study
aims
to
identify
circulating
proteins
causally
associated
with
erectile
dysfunction
(ED)
using
Mendelian
randomization
(MR)
analysis.
Methods
We
utilized
two
of
the
largest
multi-center
proteomics
databases
as
exposures
and
FinnGen
database
outcome
source.
A
large-scale
two-sample
MR
analysis,
including
coloc
colocalization
analysis
SMR
(Summary
data-based
Randomization)
was
conducted
evaluate
reliability
proteomic
effects
on
ED
outcomes.
Additionally,
mediation
involving
1,400
blood
metabolites
performed
investigate
how
these
mediate
effect
ED.
Finally,
protein-protein
interaction
pathway
enrichment
druggability
assessments,
molecular
docking
were
employed
further
elucidate
mechanisms
potential
therapeutic
targets.
Results
Eight
(AMN,
ESM1,
KIR2DL2,
PIGR,
SPINT1,
SPP1,
TNFRSF6B,
TMEM9)
identified
based
criteria.
Among
these,
five
TNFRSF6B)
satisfied
validation,
while
TMEM9,
SPP1
excluded.
Several
found
relationship
between
These
are
recognized
either
druggable
targets
or
existing
drug
targets,
results
demonstrating
favorable
interactions
various
candidates.
Conclusion
Using
we
ED,
clarified
protein-mediated
mechanisms,
proposed
promising
for
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 26, 2024
During
development,
precursor
cells
are
continuously
and
intimately
interacting
with
their
extracellular
environment,
which
guides
ability
to
generate
functional
tissues
organs.
Much
is
known
about
the
development
of
neocortex
in
mammals.
This
information
has
largely
been
derived
from
histological
analyses,
heterochronic
cell
transplants,
genetic
manipulations
mice,
a
lesser
extent
transcriptomic
analyses
humans.
However,
these
approaches
have
not
led
characterization
composition
developing
any
species.
Here,
using
combination
single-cell
published
datasets,
our
proteomics
immunohistofluorescence
we
provide
more
comprehensive
unbiased
picture
early
fetal
humans
non-human
primates.
Our
findings
starting
point
for
further
hypothesis-driven
studies
on
structural
signaling
components
cortex
that
had
previously
identified.
Experimental and Therapeutic Medicine,
Год журнала:
2024,
Номер
28(6)
Опубликована: Окт. 16, 2024
Stroke,
including
hemorrhagic
stroke
and
ischemic
stroke,
is
a
common
disease
of
the
central
nervous
system.
It
characterized
by
high
mortality
disability
rate
closely
associated
with
atherosclerosis,
hypertension
hyperglycemia,
atrial
fibrillation
unhealthy
living
habits.
The
continuous
development
surgery
medications
has
decreased
patients
greatly
improved
prognosis.
At
present,
direction
clinical
treatment
research
gradually
shifted
to
repair
nerve
function
after
stroke.
Osteopontin
(OPN)
widely
distributed
extracellular
matrix
protein.
Due
its
structural
characteristics,
OPN
can
be
cut
modified
into
terminal
fragments
different
functions,
which
play
roles
in
various
pathophysiological
processes,
such
as
formation
tumors,
inflammation
autoimmune
diseases.
also
become
potential
diagnostic
therapeutic
marker.
In
order
comprehensively
analyze
specific
role
relationship
stroke-related
diseases,
following
key
words
were
used:
'Osteopontin,
atherosis,
neuroplasticity,
neural
repair'.
PubMed,
Web
Science
Cochrane
articles
related
searched
summarized.
present
review
describes
structure,
isoforms,
functions
mechanism,
association
occurrence
diseases
was
explored.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 11857 - 11857
Опубликована: Ноя. 5, 2024
This
study
aimed
to
evaluate
the
concentration
of
osteopontin
in
peritoneal
fluid
and
plasma
as
potential
biomarkers
for
diagnosing
endometriosis.
Osteopontin
levels
were
measured
using
surface
plasmon
resonance
imaging
(SPRI)
biosensors
patients
suspected
having
Plasma
samples
collected
from
120
patients,
was
86
patients.
Based
on
detection
endometriosis
lesions
during
laparoscopy,
participants
divided
into
a
group
(patients
with
endometriosis)
control
without
endometriosis).
The
results
showed
no
significant
differences
between
women
(19.86
±
6.72
ng/mL
vs.
18.39
4.46
ng/mL,
Medical Herald of the South of Russia,
Год журнала:
2024,
Номер
15(4), С. 90 - 98
Опубликована: Окт. 17, 2024
The
presented
literature
review
allows
us
to
understand
and
supplement
the
existing
ideas
about
pathogenesis
of
coronary
calcification
aortic
valve
at
stage
formation
these
changes.
To
study
in
detail
participation
most
studied
immunocompetent
cells
innate
immunity,
such
as
macrophages,
dendritic
mast
cells,
neutrophils,
natural
killers
arteries
valve,
their
functional
role
progression
this
process.
also
presents
gaps
missing
data
present
cell
populations,
replenishment
which
will
contribute
development
targeted
therapy
for
search
sources
was
conducted
following
databases:
Scopus,
web
Science,
MedLine,
Cochrane
Library,
RSCI,
Springer,
Science
Direct
—
taking
into
account
year
publication
(no
more
than
10
years),
language
(English/Russian),
availability
full-text
publications
access
them.
