Impact of cannabinoids on cancer outcomes in patients receiving immune checkpoint inhibitor immunotherapy
MariaLuisa Vigano,
Lixing Wang,
Alia As’sadiq
и другие.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 5, 2025
Cannabinoids
relieve
pain,
nausea,
anorexia
and
anxiety,
improve
quality
of
life
in
several
cancer
patients.
The
immunotherapy
with
checkpoint
inhibitors
(ICIs),
although
very
successful
a
subset
patients,
is
accompanied
by
moderate
to
severe
immune-related
adverse
events
(ir-AE)
that
often
necessitate
its
discontinuation.
Because
their
role
symptomatic
relief,
cannabinoids
have
been
used
combination
immune
inhibitor
(ICI)
immunotherapy.
A
few
studies
strongly
suggest
the
use
medicinal
cannabis
patients
attenuates
many
ir-AE
associated
ICI
increase
tolerability.
However,
no
significant
beneficial
effects
on
overall
survival,
progression
free
survival
or
relapses
were
observed;
rather,
some
noted
concurrent
administration
clinical
benefits
latter.
cannabinoids'
well
documented
immunosuppressive
mediated
through
cannabinoid
recptor-2
(CB2),
we
propose
considering
this
receptor
as
an
inhibitory
per
se.
simultaneous
neutralization
CB2,
treatment,
may
lead
better
outcomes
receiving
In
regard,
such
cannabidiol
(CBD)
cannabigerol
(CBG),
little
agonism
for
be
therapeutic
choices.
Additional
strategies
e.g.,
monoacylglycerol
lipase
(MAGL)
degrade
endocannabinoids
lipogenesis
formation
lipid
bilayers
cells
also
explored.
Future
should
take
into
consideration
gut
microbiota,
CYP450
polymorphism
haplotypes,
cannabinoid-drug
interactions
genetic
somatic
variations
occurring
receptors
signaling
pathways
personalized
cannabis-based
therapies
ICIs.
This
rational
knowledge-based
regimens
tailored
individual
Язык: Английский
Unraveling the triad of hypoxia, cancer cell stemness, and drug resistance
Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Март 18, 2025
In
the
domain
of
addressing
cancer
resistance,
challenges
such
as
limited
effectiveness
and
treatment
resistance
remain
persistent.
Hypoxia
is
a
key
feature
solid
tumors
strongly
associated
with
poor
prognosis
in
patients.
Another
significant
portion
development
acquired
drug
attributed
to
tumor
stemness.
Cancer
stem
cells
(CSCs),
small
cell
subset
self-renewal
proliferative
abilities,
are
crucial
for
initiation,
metastasis,
intra-tumoral
heterogeneity.
Studies
have
shown
association
between
hypoxia
CSCs
context
resistance.
Recent
studies
reveal
strong
link
stemness,
which
together
promote
survival
progression
during
treatment.
This
review
elucidates
interplay
CSCs,
well
their
correlation
therapeutic
drugs.
Targeting
pivotal
genes
stemness
holds
promise
novel
therapeutics
combat
Язык: Английский
Immunohistochemical Expression of CD24 and Its Correlation with Clinicopathological Features in Malignant Surface Epithelial Tumors of the Ovary
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 31, 2025
Abstract
Background
Surface
epithelial
ovarian
cancer
(EOC)
is
the
deadliest
gynecological
malignancy,
mainly
due
to
late-stage
diagnosis
and
therapeutic
resistance.
Intratumoral
heterogeneity,
driven
by
stem
cells
(CSCs),
contributes
metastasis,
recurrence,
therapy
Cluster
of
Differentiation
24
(CD24)
has
emerged
as
a
promising
biomarker
linked
tumor
progression,
immune
evasion,
but
further
research
needed
understand
its
role
in
progression
patient
outcomes.
Aim
This
study
investigates
immunohistochemical
expression
CD24
malignant
surface
tumors
correlation
with
clinicopathological
parameters
Methods
We
performed
retrospective
cohort
analysis
involving
117
formalin-fixed,
paraffin-embedded
(FFPE)
samples
tumors,
retrieved
from
archives
Surgical
Pathology
Laboratory
at
our
University
oncology
center
period
between
2018
2021.
Patients
underwent
surgical
resection,
follow-up
data
collected
until
2024.
Immunohistochemical
(IHC)
staining
for
was
performed,
levels
were
assessed
based
on
percentage
intensity.
The
factors,
disease-free
survival
(DFS),
overall
(OS)
analyzed
using
appropriate
statistical
methods,
including
Kaplan-Meier
Cox
regression.
Results
observed
61.5%
cases,
varying
levels:
low
(17.9%),
moderate
(23.1%),
high
(20.5%).
High
predominantly
HGSC
(p
=
0.02)
significantly
associated
advanced
FIGO
stage
0.001),
grade
lymph
node
involvement
positive
peritoneal
cytology
distant
metastases
0.085).
Survival
revealed
that
patients
exhibited
shorter
DFS
0.001)
non-significant
trend
toward
reduced
OS
0.499),
compared
those
lower
or
absent
expression.
regression
identified
an
independent
predictor
poor
prognosis,
alongside
age,
stage,
involvement.
Conclusion
overexpression
strongly
correlated
aggressive
behavior,
These
findings
support
incorporation
into
risk
stratification
models
highlight
potential
CD24-targeted
therapies
improve
Язык: Английский
SYL3C Aptamer-DNA Tetrahedra Conjugates Enable Near-Infrared Fluorescent Imaging of Colorectal Cancer
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 3595 - 3606
Опубликована: Март 1, 2025
SYL3C
is
an
optimized
DNA
aptamer
with
high
selectivity
and
affinity
for
the
epithelial
cell
adhesion
molecule
(EpCAM),
overexpressed
tumor
antigen
in
colorectal
cancer
(CRC).
While
its
cellular
has
been
validated,
vivo
studies
are
lacking.
This
study
modifies
fluorescent
motif
Cy7
to
evaluate
metabolism
diagnostic
potential
EpCAM-positive
HT-29
xenograft
mice
using
near-infrared
fluorescence
(NIRF).
We
also
employ
Tetrahedra
(DTN)
load
Cy7-DTN-SYL3C
probe
assess
whether
this
strategy
improves
circulation
uptake
of
SYL3C.
Cy7-SYL3C
primarily
metabolized
by
kidneys
enables
targeted
imaging
tumors,
outperforming
untargeted
Cy7-DTN.
The
DTN
coupling
prolongs
enhances
about
twice
higher
than
over
24
hours.
presents
preliminary
evidence
aptamer's
CRC.
conjugation
may
extend
metabolic
stability
improve
uptake,
expanding
applications
CRC
diagnosis
treatment.
Язык: Английский
The Immunoexpression and Prognostic Significance of Stem Cell Markers in Malignant Salivary Gland Tumors: A Systematic Review and Meta-Analysis
Genes,
Год журнала:
2024,
Номер
16(1), С. 37 - 37
Опубликована: Дек. 29, 2024
Background/Objectives:
Salivary
gland
carcinomas
encompass
a
broad
group
of
malignant
lesions
characterized
by
varied
prognoses.
Stem
cells
have
been
associated
with
the
potential
for
self-renewal
and
differentiation
to
various
subpopulations,
resulting
in
histopathological
variability
diverse
biological
behavior,
features
that
characterize
salivary
carcinomas.
This
study
aims
provide
thorough
systematic
review
immunohistochemical
studies
regarding
expression
prognostic
significance
stem
cell
markers
between
different
tumors
(MSGTs).
Methods:
The
English
literature
was
searched
via
databases
MEDLINE/PubMed,
EMBASE
OVID,
Web
Science,
Scopus,
CINHAL
EBSCO.
Joanna
Briggs
Institute
Critical
Appraisal
Tool
used
risk
bias
(RoB)
assessment.
Meta-analysis
conducted
evaluated
same
pair
diseases
at
least
two
studies.
Results:
Fifty-four
reported
markers,
e.g.,
c-KIT,
CD44,
CD133,
CD24,
ALDH1,
BMI1,
SOX2,
OCT4,
NANOG,
MSGTs.
Low,
moderate,
high
RoB
observed
twenty-five,
eleven,
eighteen
studies,
respectively.
revealed
an
outstanding
discriminative
ability
c-KIT
adenoid
cystic
carcinoma
(AdCC)
over
polymorphous
adenocarcinoma
[P(LG)A]
but
did
not
confirm
Conclusions:
indicated
possible
link
heterogeneity
behavior
might
be
diagnostic
value
discriminating
AdCC
P(LG)A.
Язык: Английский