IL-7 in autoimmune diseases: mechanisms and therapeutic potential DOI Creative Commons

Ziyuan Zeng,

Hanxiao Mao,

Qirong Lei

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 17, 2025

Interleukin-7 (IL-7) is a pleiotropic cytokine that plays crucial role in the development, homeostasis, and function of immune system. Growing evidence has demonstrated IL-7 involved pathogenesis various autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type 1 diabetes (T1D) multiple sclerosis (MS). This review aims to summarize current understanding diseases, focusing on its mechanisms action, implications for disease progression, potential therapeutic applications. Produced by stromal cells, binds receptor (IL-7R) diverse cells. It T cell survival, proliferation. In it activates expands autoreactive cells influences B function, potentially leading autoantibody production. The further delves into different diseases. RA, elevated IL-7/IL-7R promotes memory production, monocytes contribute inflammation joint damage. SLE, soluble form IL-7R associated with activity, promoting survival enhancing production pro-inflammatory cytokines. MS, genetic variations gene are linked susceptibility, impacts differentiation subsets pathogenesis. For T1D, affects attack pancreatic β Given central processes, targeting axis holds great potential. By modulating signaling, may be possible restore tolerance, reduce activation alleviate symptoms. Understanding complex essential development effective targeted therapies.

Язык: Английский

IL-7 in autoimmune diseases: mechanisms and therapeutic potential DOI Creative Commons

Ziyuan Zeng,

Hanxiao Mao,

Qirong Lei

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 17, 2025

Interleukin-7 (IL-7) is a pleiotropic cytokine that plays crucial role in the development, homeostasis, and function of immune system. Growing evidence has demonstrated IL-7 involved pathogenesis various autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type 1 diabetes (T1D) multiple sclerosis (MS). This review aims to summarize current understanding diseases, focusing on its mechanisms action, implications for disease progression, potential therapeutic applications. Produced by stromal cells, binds receptor (IL-7R) diverse cells. It T cell survival, proliferation. In it activates expands autoreactive cells influences B function, potentially leading autoantibody production. The further delves into different diseases. RA, elevated IL-7/IL-7R promotes memory production, monocytes contribute inflammation joint damage. SLE, soluble form IL-7R associated with activity, promoting survival enhancing production pro-inflammatory cytokines. MS, genetic variations gene are linked susceptibility, impacts differentiation subsets pathogenesis. For T1D, affects attack pancreatic β Given central processes, targeting axis holds great potential. By modulating signaling, may be possible restore tolerance, reduce activation alleviate symptoms. Understanding complex essential development effective targeted therapies.

Язык: Английский

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