Intestinal Microbiota Contributes to the Development of Cardiovascular Inflammation and Vasculitis in Mice DOI
Prasant Kumar Jena,

Daiko Wakita,

Angela C. Gomez

и другие.

Circulation Research, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

BACKGROUND: Alterations in the intestinal microbiota contribute to pathogenesis of various cardiovascular disorders, but how they affect development Kawasaki disease, an acute pediatric vasculitis, remains unclear. Here, using a murine model mimicking disease we assessed contribution vascular inflammation. METHODS AND RESULTS: We report that depleting gut reduces inflammation vasculitis. The lesions was associated with alterations composition and, notably, decreased abundance Akkermansia muciniphila and Faecalibacterium prausnitzii . Oral supplementation either these live or pasteurized individual bacteria short-chain fatty acids produced by them attenuated inflammation, as reflected local immune cell infiltrations. Treatment Amuc_1100, TLR-2 signaling outer membrane protein from , also reduced severity CONCLUSIONS: This study reveals underappreciated microbiota-cardiovascular axis vasculitis identifies specific commensals regulate mice producing metabolites via extracellular proteins capable enhancing supporting barrier function.

Язык: Английский

Risk factors for predicting medium-giant coronary artery aneurysms in Kawasaki disease DOI
Li Zhao, Jiangping Wu, Xiaoliang Liu

и другие.

Immunologic Research, Год журнала: 2025, Номер 73(1)

Опубликована: Фев. 17, 2025

Язык: Английский

Процитировано

0
Unveiling the anti-inflammatory mechanism of exogenous hydrogen sulfide in Kawasaki disease based on network pharmacology and experimental validation DOI Creative Commons

Ling Yu,

Qianwen Luo,

Xiaohui Rao

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 3, 2025

Kawasaki disease (KD) is a severe pediatric vasculitis leading to coronary artery complications. Hydrogen sulfide (H2S), recognized endogenous gasotransmitter with anti-inflammatory properties, offers potential as novel treatment for KD through its cardiovascular benefits. However, the specific effects and underlying mechanisms remain unclear. The objective of present study investigate therapeutic exogenous H2S in using network pharmacology experimental validation. By online database searches, total 405 pharmacological targets H2S, 826 KD-related targets, 107 were identified. Through PPI analysis Cytoscape screening, 9 hub genes filtered, namely TNF, IL6, JUN, AKT1, IL1B, TP53, NFKB1, MAPK1, RELA. KEGG pathway enrichment indicated that TLR4/MyD88/NF-κB signaling may play crucial role on KD. Additionally, vivo experiments confirmed sodium hydrosulfide (NaHS), an donor, markedly improved body weight, reduced inflammatory pathology arteries, downregulated levels cytokines TNF-α, IL-1β, IL-6. Furthermore, WB NaHS inhibited expression TLR4, MyD88, NF-κB, p-NF-κB. In brief, it first reveal attenuates response via pathway, highlighting approach These findings lay foundation further development H2S-based therapies management.

Язык: Английский

Процитировано

0
Intestinal Microbiota Contributes to the Development of Cardiovascular Inflammation and Vasculitis in Mice DOI
Prasant Kumar Jena,

Daiko Wakita,

Angela C. Gomez

и другие.

Circulation Research, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

BACKGROUND: Alterations in the intestinal microbiota contribute to pathogenesis of various cardiovascular disorders, but how they affect development Kawasaki disease, an acute pediatric vasculitis, remains unclear. Here, using a murine model mimicking disease we assessed contribution vascular inflammation. METHODS AND RESULTS: We report that depleting gut reduces inflammation vasculitis. The lesions was associated with alterations composition and, notably, decreased abundance Akkermansia muciniphila and Faecalibacterium prausnitzii . Oral supplementation either these live or pasteurized individual bacteria short-chain fatty acids produced by them attenuated inflammation, as reflected local immune cell infiltrations. Treatment Amuc_1100, TLR-2 signaling outer membrane protein from , also reduced severity CONCLUSIONS: This study reveals underappreciated microbiota-cardiovascular axis vasculitis identifies specific commensals regulate mice producing metabolites via extracellular proteins capable enhancing supporting barrier function.

Язык: Английский

Процитировано

0