Recent advances in mesenchymal stem cell therapy for multiple sclerosis: clinical applications and challenges DOI Creative Commons

Kamran Sheikhi,

Sara Ghaderi,

Hassan Firouzi

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Фев. 3, 2025

Multiple sclerosis (MS), a chronic autoimmune disorder of the central nervous system (CNS), is characterized by inflammation, demyelination, and neurodegeneration, leading to diverse clinical manifestations such as fatigue, sensory impairment, cognitive dysfunction. Current pharmacological treatments primarily target immune modulation but fail arrest disease progression or entirely reverse CNS damage. Mesenchymal stem cell (MSC) therapy offers promising alternative, leveraging its immunomodulatory, neuroprotective, regenerative capabilities. This review provides an in-depth analysis MSC mechanisms action, including regulation, promotion remyelination, neuroregeneration. It examines preclinical studies trials evaluating efficacy, safety, limitations in various MS phenotypes. Special attention given challenges delivery routes, dosing regimens, integrating MSCs with conventional therapies. By highlighting advancements ongoing challenges, this underscores potential revolutionize treatment, paving way for personalized combinatory therapeutic approaches.

Язык: Английский

Recent advances in mesenchymal stem cell therapy for multiple sclerosis: clinical applications and challenges DOI Creative Commons

Kamran Sheikhi,

Sara Ghaderi,

Hassan Firouzi

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Фев. 3, 2025

Multiple sclerosis (MS), a chronic autoimmune disorder of the central nervous system (CNS), is characterized by inflammation, demyelination, and neurodegeneration, leading to diverse clinical manifestations such as fatigue, sensory impairment, cognitive dysfunction. Current pharmacological treatments primarily target immune modulation but fail arrest disease progression or entirely reverse CNS damage. Mesenchymal stem cell (MSC) therapy offers promising alternative, leveraging its immunomodulatory, neuroprotective, regenerative capabilities. This review provides an in-depth analysis MSC mechanisms action, including regulation, promotion remyelination, neuroregeneration. It examines preclinical studies trials evaluating efficacy, safety, limitations in various MS phenotypes. Special attention given challenges delivery routes, dosing regimens, integrating MSCs with conventional therapies. By highlighting advancements ongoing challenges, this underscores potential revolutionize treatment, paving way for personalized combinatory therapeutic approaches.

Язык: Английский

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