Ginsenoside Rg3 Alleviates Xerostomia in Orchiectomized Mice via AR/AQP5

Journal of Dental Research, Год журнала: 2025, Номер unknown

Опубликована: Фев. 4, 2025

Sjögren’s disease (SjD), an autoimmune inflammatory disease, is associated with reduced androgen levels. Testosterone replacement therapy alleviates SjD progression, but the exact mode of action unclear and adverse effects are reported. Our present study found that dihydrotestosterone (DHT) enhances transcription expression aquaporin 5 (AQP5) in human salivary gland epithelial cells via receptor (AR) signaling. The DHT/AR complex binds to response element AQP5 promoter, upregulating expression. Using orchiectomized mice, we observed levels DHT resulted hyposalivation progression. By screening compounds similar structures DHT, identified DHT-like ginsenoside Rg3, a natural product, upregulates binding AR. Rg3/AR acts like promoter promote cells. Gavage Rg3 restored saliva secretion submandibular morphology nonobese diabetic mice. Transcriptome analysis revealed treatment secretion–related signaling downregulates inflammation immune activation–related glands In conclusion, our results indicated restores deficiency–triggered xerostomia AR-mediated upregulation.

Язык: Английский

The tumor cell killing capacity of head and neck cancer patient-derived neutrophils depends on tumor stage, gender and the antibody isotype

Oral Oncology, Год журнала: 2024, Номер 159, С. 107042 - 107042

Опубликована: Сен. 21, 2024

Язык: Английский

Androgen receptor signalling in non-prostatic malignancies: challenges and opportunities

Nature reviews. Cancer, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

Язык: Английский