Prospective Application of Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Disseminated Intravascular Coagulation DOI Creative Commons

Chengran Wang,

Xiaoqing Zhao, Keyan Wang

и другие.

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 11957 - 11971

Опубликована: Ноя. 1, 2024

Disseminated intravascular coagulation (DIC) is an acquired disorder characterized by systemic activation of blood coagulation, which can arise from various causes. Owing to its abrupt onset, rapid progression, and high mortality rate, DIC presents a major clinical challenge. Anticoagulant drugs, such as heparin or low-molecular-weight heparin, are the current gold standard treatment; however, these interventions pose considerable bleeding risks. Thus, safer more effective therapeutic strategies urgently required. their strong anti-inflammatory tissue repair capabilities, mesenchymal stem cell-derived exosomes (MSC-Exos) have gained attention novel options for numerous disorders, including DIC. Their stability in diverse pathological states highlights potential promising candidates therapy. This review latest insights on pathogenesis anticoagulant properties MSC-Exos. We aimed elucidate mechanisms MSC-Exos influence pathogenesis. speculate that offer multifaceted approach treatment attenuating neutrophil extracellular trap formation, modulating M1/M2 macrophage polarization, altering Nrf2/NF-κB signalling pathway downregulate pro-inflammatory factors, correcting imbalances coagulation-fibrinolysis system through routes. suggests paradigm therapy, offering targets modalities management.

Язык: Английский

A mendelian randomization study on the association between 731 types of immune cells and 91 types of blood cells with venous thromboembolism DOI Creative Commons
Yue Zhang, Rui Wang

Thrombosis Journal, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 3, 2025

Venous thromboembolism (VTE) is a grave medical condition characterized by the blockage of distant blood vessels due to clots or detached vessel wall fragments, leading ischemia necrosis affected tissues. With recent introduction immunothrombosis, significance immune cells in process thrombus formation has gained prominent attention. Complex cross-talk occurs between and during infection inflammation, with actively participating clot promoting platelet recruitment thrombin activation. Nevertheless, comprehensive studies on genetic association phenotypes VTE remain scarce. This article employed Mendelian randomization (MR) investigate incidence range 731 cell types, along 91 perturbation phenotypes, utilizing single nucleotide polymorphisms as instrumental variables. Through utilization publicly available data, two-sample bi-directional MR analysis was conducted. Sensitivity analyses included Cochran's Q test, MR-Egger intercept MR-pleiotropy residual sum outlier (MR-PRESSO) leave-one-out analysis. For significant associations, replication conducted using GWAS data from deep vein thrombosis (DVT) pulmonary embolism (PE). We firstly investigated causal relationship risk. All were obtained European populations men women. The IVW revealed that CD20 naive-mature B cell, IgD- CD38dim unswitched memory may increase risk (P < 0.05). CD28- CD8dim T %T CD64 monocyte CD14 + CD16- be protective factors against DVT Then disturbed types exposure analyzed examine its occurrence VTE. Initial both environmental KCl-impacted red butyric acid-impacted accelerated 0.05), while colchicine -impacted eosinophil, reticulocyte Lipopolysaccharide (LPS) neutrophil reduced confirmed robustness reliability these positive findings. Our study presents evidence link six Additionally, we have identified two are associated DVT, three relevant PE. Not applicable.

Язык: Английский

Процитировано

0
KLF15 regulates macrophage polarization patterns in deep vein thrombosis DOI Creative Commons

Jizheng Li,

Yaoyu Xiang,

Haopeng Shentu

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 155, С. 114632 - 114632

Опубликована: Апрель 10, 2025

KLF15 is involved in cardiovascular disease processes by regulating vascular remodeling and metabolic disorders. Macrophages mediate the inflammatory response deep vein thrombosis (DVT) secreting cytokines modulating fibrinolytic system. Therefore, this study aims to discuss effect of on macrophage polarization DVT. In vivo, a DVT animal model was used assess expression polarization. vitro, PMA-treated THP-1 cells with overexpression were differentiated into M1- M2-like macrophages, markers analyzed molecular cellular assays. vivo experiments, levels KLF15, iNOS, CD206, IL-1β, IL-6, IL-10 TGF-β increased model. vitro augmented CD86, IL-12, TNF-α, IL-6 M1-like macrophages. Additionally, diminished IL-10, ARG1, CUT&Tag, peaks bound lgG mainly located promoter intronic regions, protein more than near TSS site. YY1, EIF4E, LCK, HMGB1, GPD2, MORF4L1, HIPK2 NEK2 hub genes that bind KLF15. ChIP assay confirmed macrophages enhanced its transcription NF-κB pathway activity. facilitates M1 via NEK2/NF-κB pathway, highlighting potential as therapeutic target for management. Future studies are warranted explore clinical applicability mechanistic nuances.

Язык: Английский

Процитировано

0
Molecular Mechanism of Notch Signaling and Macrophages in Deep Vein Thrombosis: A Comprehensive Review DOI

Shona Joy,

Anusha Prasannan,

Kaliyamurthi Venkatachalam

и другие.

Cell Biochemistry and Biophysics, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Язык: Английский

Процитировано

0
Targeting toll-like receptors: unveiling potential therapeutic strategies for deep vein thrombosis DOI Creative Commons
Wei Shao, Zilong Wang, Jian Wu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Май 29, 2025

Deep vein thrombosis (DVT) is a complex multifactorial vascular disease characterized by abnormal blood stasis and coagulation within the deep veins, primarily occurring in lower limbs. This pathological condition not only causes local circulatory disruption but also has potential to trigger life-threatening pulmonary embolism through thrombus detachment, thus posing major threat human health. Toll - like receptors (TLRs), essential components of innate immune system, have been increasingly acknowledged as crucial determinants pathogenesis DVT. TLRs possess ability recognize diverse range pathogen associated molecular patterns (PAMPs) endogenous danger (DAMPs). Upon activation, they cascade inflammatory responses that are intricately intertwined with thrombotic process. review comprehensively scrutinizes extant knowledge pertaining role It systematically synthesizes mechanisms underpinning participation DVT, spanning platelet endothelial cell dysfunction, leukocyte recruitment. Moreover, it delves profoundly into targeting therapeutic strategies for entails exploration development application TLR inhibitors or antagonists. By elucidating these aspects, objective proffer novel perspectives insights prevention treatment

Язык: Английский

Процитировано

0
Prospective Application of Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Disseminated Intravascular Coagulation DOI Creative Commons

Chengran Wang,

Xiaoqing Zhao, Keyan Wang

и другие.

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 11957 - 11971

Опубликована: Ноя. 1, 2024

Disseminated intravascular coagulation (DIC) is an acquired disorder characterized by systemic activation of blood coagulation, which can arise from various causes. Owing to its abrupt onset, rapid progression, and high mortality rate, DIC presents a major clinical challenge. Anticoagulant drugs, such as heparin or low-molecular-weight heparin, are the current gold standard treatment; however, these interventions pose considerable bleeding risks. Thus, safer more effective therapeutic strategies urgently required. their strong anti-inflammatory tissue repair capabilities, mesenchymal stem cell-derived exosomes (MSC-Exos) have gained attention novel options for numerous disorders, including DIC. Their stability in diverse pathological states highlights potential promising candidates therapy. This review latest insights on pathogenesis anticoagulant properties MSC-Exos. We aimed elucidate mechanisms MSC-Exos influence pathogenesis. speculate that offer multifaceted approach treatment attenuating neutrophil extracellular trap formation, modulating M1/M2 macrophage polarization, altering Nrf2/NF-κB signalling pathway downregulate pro-inflammatory factors, correcting imbalances coagulation-fibrinolysis system through routes. suggests paradigm therapy, offering targets modalities management.

Язык: Английский

Процитировано

0