Metformin in Antiviral Therapy: Evidence and Perspectives DOI Creative Commons
Iryna Halabitska, Pavlo Petakh, Oleh Lushchak

и другие.

Viruses, Год журнала: 2024, Номер 16(12), С. 1938 - 1938

Опубликована: Дек. 18, 2024

Metformin, a widely used antidiabetic medication, has emerged as promising broad-spectrum antiviral agent due to its ability modulate cellular pathways essential for viral replication. By activating AMPK, metformin depletes energy reserves that viruses rely on, effectively limiting the replication of pathogens such influenza, HIV, SARS-CoV-2, HBV, and HCV. Its role in inhibiting mTOR pathway, crucial protein synthesis reactivation, is particularly significant managing infections caused by CMV, EBV. Furthermore, reduces oxidative stress reactive oxygen species (ROS), which are critical replicating arboviruses Zika dengue. The drug also regulates immune responses, differentiation, inflammation, disrupting life cycle HPV potentially other viruses. These diverse mechanisms suppress replication, enhance system functionality, contribute better clinical outcomes. This multifaceted approach highlights metformin’s potential an adjunctive therapy treating wide range infections.

Язык: Английский

Activated platelet membrane vesicles for broad-spectrum bacterial pulmonary infections management DOI

Anqi Wei,

Tianhao Ding,

Guanghui Li

и другие.

Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 846 - 859

Опубликована: Фев. 19, 2025

Язык: Английский

Процитировано

0
The Role of Fibroblast Growth Factors in Viral Replication: FGF-2 as a Key Player DOI Creative Commons

Danial Zareh,

Reyhaneh Nekounam Ghadirli,

Hao Zuo

и другие.

IntechOpen eBooks, Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

Fibroblast growth factors (FGFs) are crucial signaling proteins that govern numerous cellular activities, such as proliferation, differentiation, and tissue repair. Recent studies indicate FGFs, particularly FGF-2, pivotal in viral replication by altering the host cell environment to promote survival, replication, immune evasion. Viruses rely on components for their often manipulate pathways, including FGF signaling, optimize growth. Among various FGF-2 (basic FGF) stands out influential due its roles angiogenesis, modulation. This chapter explores molecular processes via which FGFs affect life cycles, highlighting is notably important promoting impact inflammation. Understanding FGF-mediated may offer new therapeutic targets infections.

Язык: Английский

Процитировано

0
A comprehensive update on the use of molecular topology applications for anti-infective drug discovery DOI Creative Commons
Beatriz Suay‐García, Joan Climent, María Teresa Pérez‐Gracia

и другие.

Expert Opinion on Drug Discovery, Год журнала: 2025, Номер unknown

Опубликована: Март 8, 2025

Introduction The rapid emergence of infectious diseases poses a significant threat to global economies and public health. To combat this, it is crucial develop effective treatments. One essential tool in drug design molecular topology, which uses topological indices build QSAR models. This mathematical framework describes chemical compound structures, facilitating easy characterization.

Язык: Английский

Процитировано

0
Host Immunity and Intracellular Bacteria Evasion Mechanisms: Enhancing Host-Directed Therapies with Drug Delivery Systems DOI
Jiayang Cai,

Han Zhou,

Mingwei Liu

и другие.

International Journal of Antimicrobial Agents, Год журнала: 2025, Номер unknown, С. 107492 - 107492

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Non-antiviral therapies for viral infections: Harnessing host mechanisms DOI
Sruthi Sarvepalli,

Shubhadeepthi Vadarevu

International Immunopharmacology, Год журнала: 2025, Номер 153, С. 114521 - 114521

Опубликована: Март 27, 2025

Язык: Английский

Процитировано

0
Metformin in Antiviral Therapy: Evidence and Perspectives DOI Creative Commons
Iryna Halabitska, Pavlo Petakh, Oleh Lushchak

и другие.

Viruses, Год журнала: 2024, Номер 16(12), С. 1938 - 1938

Опубликована: Дек. 18, 2024

Metformin, a widely used antidiabetic medication, has emerged as promising broad-spectrum antiviral agent due to its ability modulate cellular pathways essential for viral replication. By activating AMPK, metformin depletes energy reserves that viruses rely on, effectively limiting the replication of pathogens such influenza, HIV, SARS-CoV-2, HBV, and HCV. Its role in inhibiting mTOR pathway, crucial protein synthesis reactivation, is particularly significant managing infections caused by CMV, EBV. Furthermore, reduces oxidative stress reactive oxygen species (ROS), which are critical replicating arboviruses Zika dengue. The drug also regulates immune responses, differentiation, inflammation, disrupting life cycle HPV potentially other viruses. These diverse mechanisms suppress replication, enhance system functionality, contribute better clinical outcomes. This multifaceted approach highlights metformin’s potential an adjunctive therapy treating wide range infections.

Язык: Английский

Процитировано

1