An updated review on abnormal epigenetic modifications in the pathogenesis of systemic lupus erythematosus

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 6, 2025

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. The inconsistent prevalence of SLE between monozygotic twins suggests that environmental factors affect the occurrence this Abnormal epigenetic regulation strongly associated with pathogenesis SLE. Epigenetic mechanisms may be involved in development through DNA methylation, histone modification, noncoding RNAs, and other modifications. This review aims to show numerous studies as treasure map better understand effects aberrant modification onset SLE, which will benefit current basic research provide potential diagnostic biomarkers or therapeutic targets for

Язык: Английский

Fractional excretion ratio of activated leukocyte cell adhesion molecule (ALCAM) as a potential biomarker in lupus nephritis patients

The Egyptian Rheumatologist, Год журнала: 2025, Номер 47(3), С. 104 - 109

Опубликована: Апрель 12, 2025

Язык: Английский