Klotho protein: A key modulator of aging and COVID-19 severity
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 139234 - 139234
Опубликована: Янв. 1, 2025
Язык: Английский
Suyin Detoxification Prescription Regulates the Klotho and ERK/NF-κB Signaling Pathways to Alleviate Renal Injury
Cell Biochemistry and Biophysics,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 18, 2025
Язык: Английский
A comparative genomic study across 396 liver biopsies provides deep insight into FGF21 mode of action as a therapeutic agent in metabolic dysfunction‐associated steatotic liver disease
Clinical and Translational Medicine,
Год журнала:
2025,
Номер
15(2)
Опубликована: Фев. 1, 2025
Язык: Английский
Soluble average Klotho level as a prognostic marker for acute kidney injury outcomes: a 90-day follow-up study
Biomarkers in Medicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 8
Опубликована: Март 22, 2025
Background
Klotho
is
highly
expressed
in
the
kidney
and
confers
pleiotropic
protective
effects.
This
study
aimed
to
assess
soluble
average
level
its
relationship
renal
function
outcomes
participants
with
acute
injury
(AKI).
Язык: Английский
Natural products in traditional Chinese medicine for renal fibrosis: a comprehensive review
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 16, 2025
Renal
fibrosis
represents
the
terminal
pathological
manifestation
of
most
chronic
kidney
diseases,
driving
progressive
loss
renal
function.
Natural
products
have
emerged
as
promising
therapeutic
agents
for
preventing
and
ameliorating
due
to
their
multi-target
efficacy
favorable
safety
profiles.
In
this
review,
we
conducted
a
comprehensive
literature
search
on
PubMed
using
keywords
“natural
product”
“renal
fibrosis”
from
2004
2025,
identifying
704
relevant
articles.
We
systematically
categorize
discuss
biological
effects
key
natural
formulations
with
antifibrotic
potential,
focusing
five
major
classes:
glycosides,
flavonoids,
phenolic
compounds,
anthraquinones,
terpenoids.
Representative
compounds
each
category
are
highlighted
mechanisms
action,
including
modulation
oxidative
stress,
inflammation,
autophagy,
signaling
pathways.
This
review
aims
provide
theoretical
foundation
development
product-based
therapies
combat
fibrosis,
offering
insights
into
potential
future
research
directions.
Язык: Английский
The role of serum α-Klotho levels in preventing hearing impairment among middle-aged and older adults: insights from a nationally representative sample
Frontiers in Aging Neuroscience,
Год журнала:
2024,
Номер
16
Опубликована: Ноя. 14, 2024
Background
The
Klotho
gene
is
implicated
in
suppressing
aging
phenotypes
and
influencing
age-related
diseases.
Previous
studies
have
delved
into
its
connection
with
different
diseases,
yet
the
association
between
hearing
loss
has
rarely
been
examined.
A
recent
population
study
explored
relationship
serum
loss,
but
it
had
certain
limitations.
This
aims
to
analyze
link
α-Klotho
levels
thresholds,
as
well
risk
of
loss.
Methods
total
1,762
adults
aged
40–69
years
were
selected
from
2011–2012
National
Health
Nutrition
Examination
Survey
(NHANES).
Data
on
audiometry,
levels,
relevant
covariates
gathered.
Statistical
analyses,
including
linear
logistic
regression,
assessed
relationships
outcomes.
Results
Increased
correlated
diminished
thresholds
a
lower
Quartile
analysis
revealed
significant
trend,
where
elevated
linked
better
auditory
Adjusted
models
controlled
for
various
covariates,
affirming
robustness
findings.
Non-linear
associations
not
observed.
Conclusion
provided
novel
evidence
negative
impairment
40–69.
Our
results
suggested
protective
role
Язык: Английский