Personalized translational medicine: Investigating YKL-40 as early biomarker for clinical risk stratification in hepatocellular carcinoma recurrence post-liver transplantation
World Journal of Transplantation,
Год журнала:
2025,
Номер
15(2)
Опубликована: Фев. 21, 2025
Hepatocellular
carcinoma
(HCC)
recurrence
after
liver
transplantation
(LT)
presents
a
significant
challenge,
with
rates
ranging
from
8%
to
20%
globally.
Current
biomarkers,
such
as
alpha-fetoprotein
(AFP)
and
des-gamma-carboxy
prothrombin
(DCP),
lack
specificity,
limiting
their
utility
in
risk
stratification.
YKL-40,
glycoprotein
involved
extracellular
matrix
remodeling,
hepatic
stellate
cell
activation,
immune
modulation,
has
emerged
promising
biomarker
for
post-LT
surveillance.
Elevated
serum
levels
of
YKL-40
are
associated
advanced
disease,
tumor
progression,
poorer
outcomes,
highlighting
its
potential
address
gaps
early
detection
personalized
management
HCC
recurrence.
This
manuscript
synthesizes
clinical
mechanistic
evidence
evaluate
YKL-40’s
predictive
care.
While
preliminary
findings
demonstrate
specificity
liver-related
pathologies,
challenges
remain,
including
assay
standardization,
prospective
validation,
the
need
distinguish
between
malignant
non-malignant
causes
elevated
levels.
Integrating
into
multi-biomarker
panels
AFP
DCP
could
enhance
accuracy
enable
tailored
therapeutic
strategies.
Future
research
should
focus
on
multicenter
studies
validate
utility,
confounding
factors
like
graft
rejection
systemic
inflammation,
explore
role
models
driven
by
emerging
technologies
artificial
intelligence.
holds
transformative
reshaping
care
through
precision
medicine,
providing
pathway
better
outcomes
improved
high-risk
LT
recipients.
Язык: Английский
Global research status and frontiers on ferroptosis in hepatocellular carcinoma: a comprehensive bibliometric and visualized analysis
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Май 2, 2025
Objective
The
purpose
of
this
study
was
to
analyze
the
research
hotspots
and
future
trends
in
field
ferroptosis
hepatocellular
carcinoma
past
10
years
by
using
bibliometrics
visualization
software,
provide
reference
for
directions
field.
Methods
Web
Science
database
searched
from
January
1,
2012,
October
30,
2024,
annual
publication
volume,
countries,
institutions,
journals,
authors,
references,
keywords,
other
information
were
analyzed
bibliometrics,
VOSviewer,
CiteSpace.
Results
A
total
645
English
articles
729
institutions
32
countries
included
study,
with
4545
authors
published
261
journals.
In
three
years,
518
published,
accounting
80.3%.
China
has
most
publications,
followed
United
States.
Frontiers
Oncology
had
highest
number
papers
(n=26),
while
Cell
citations
(n=1206).
current
mainly
focuses
on
two
aspects:
one
is
mechanism
explore
new
therapeutic
targets,
exploration
methods,
such
as
photodynamic
therapy
nanomaterials,
order
inhibit
proliferation
tumor
cells,
reduce
drug
resistance,
enhance
efficacy
regulating
ferroptosis,
which
may
become
a
development
trend.
Conclusion
recent
there
have
been
increasing
studies
association
between
carcinoma.
This
first
comprehensive
bibliometric
provides
reliable
promotes
its
further
development.
Язык: Английский
Research Trends on Nanomaterials and Hepatocellular Carcinoma From 1999 to 2024: A Bibliometric Analysis
Drug Design Development and Therapy,
Год журнала:
2025,
Номер
Volume 19, С. 3949 - 3970
Опубликована: Май 1, 2025
Extensive
exploratory
studies
have
been
conducted
and
promising
progress
has
made
in
the
use
of
nanomaterials
for
diagnosis
treatment
hepatocellular
carcinoma
(HCC).
Here,
we
aimed
to
reveal
evolution
trends
this
field
through
bibliometric
analysis.
English-language
publications
(1999-2024)
HCC
were
retrieved
from
Web
Science
database,
eligible
articles
selected
analysis
(data
extraction,
statistical
analysis,
visualization)
using
VOSviewer
Citespace
software.
A
total
1617
analyzed.
The
number
increased
rapidly
2012
peaked
2020.
China
contributed
most
publications,
United
States
had
citations.
Chinese
Academy
Sciences
was
influential
institution.
"International
Journal
Nanomedicine
(DOVE
Medical)"
published
articles,
while
"Biomaterials
(Elsevier)"
journal.
Jie
Tian
highest
Dan
Shao
average
citation
per
article.
Keyword
revealed
that
nanoparticles
targeted
drug
delivery,
therapy
imaging
research
hotspots.
Keywords
with
bursts
last
three
years
included
photodynamic
therapy,
sorafenib,
tumor
microenvironment.
Nano-vaccines,
nano-antibodies,
synergistic
therapies
emerging
therapeutic
strategies.
seven
clinical
trials
published,
but
date
there
no
major
breakthroughs
nanomaterials.
Research
on
shown
an
overall
upward
trend,
hotspots
frontiers
focusing
nanoparticle-targeted
chemotherapies,
related
microenvironment
research.
Язык: Английский