Gut microbiota and their metabolites in the immune response of rheumatoid arthritis: Therapeutic potential and future directions

International Immunopharmacology, Год журнала: 2025, Номер 147, С. 114034 - 114034

Опубликована: Янв. 12, 2025

Язык: Английский

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Mucosal immunity and rheumatoid arthritis: An update on mechanisms and therapeutic potential

Autoimmunity Reviews, Год журнала: 2025, Номер 24(5), С. 103775 - 103775

Опубликована: Фев. 13, 2025

Rheumatoid Arthritis (RA) is a persistent autoimmune inflammatory disorder that arises from the intricate interaction between genetic predisposition and environmental influences. The progression of RA can be delineated into four distinct phases: initially, influence risk factors; followed by emergence systemic autoimmunity; subsequently, an asymptomatic phase; ultimately, manifestation clinical arthritis. Recently, role mucosal immunity in has gained significant attention research. Evidence published studies suggests not only influences onset but also plays crucial its progression. Scholars have begun to unravel links barriers gastrointestinal tract, respiratory system, oral cavity. Specifically, shifts microbiota, dysfunction barriers, abnormal activation immune tissues are all implicated pathogenesis RA.Despite this growing body knowledge, comprehensive review therapeutic implications yet conducted. This emphasizes driving abnormalities development autoimmunity rheumatoid arthritis (RA). It further explores potential RA, as well issues challenges need addressed current research field, providing new perspective targets for prevention treatment RA.

Язык: Английский

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Regulating Rheumatoid Arthritis From the Perspective of Metabolomics: A Comprehensive Review

International Journal of Rheumatic Diseases, Год журнала: 2025, Номер 28(3)

Опубликована: Март 1, 2025

ABSTRACT Rheumatoid arthritis (RA) is a severe inflammatory autoimmune disease with metabolic changes. RA patients have abnormalities in glycolysis, amino acid metabolism, choline and fatty synthesis. The differential metabolites individuals of animal models were explored to find the potential biomarkers for risk prediction, diagnosis, prognosis perspective metabolism. Moreover, we discussed changes related after treatment anti‐rheumatic drugs, Traditional Chinese Medicine (TCM) explore promising metabolites. In addition, immunological mechanism TCM from metabolism was also clarified. For perspectives research application beneficial clinic, relevant technologies focuses future studies field been proposed accordingly.

Язык: Английский

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Resolution of inflammation during rheumatoid arthritis

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Март 26, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes synovial joint inflammation as well bone destruction and erosion, typically characterized by pain, swelling, stiffness, with complications persistent pain after remission posing significant health burden for RA patients. The etiology of has not yet been fully elucidated, but large number studies have shown the initiation in closely related to T-cell activation, production variety pro-inflammatory cytokines, macrophage M1/M2 imbalance, homeostatic imbalance intestinal flora, fibroblast-like synoviocytes (FLSs) tissue macrophages (STMs) lumen joints exhibit an aggressive phenotype. While resolution less discussed, therefore, we provided systematic review relevant mechanisms including blocking T cell regulating polarization status, modulating signaling pathway FLSs, subpopulation STMs, inhibiting inflammatory factors, probable its management methods. Achieving crucial improving quality life long-term prognosis Thus, understanding these provide novel potential further drug development treatment RA.

Язык: Английский

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Tinosporine alleviates collagen-induced arthritis in rats via modulating the gut microbiota-metabolome-immunity axis

International Immunopharmacology, Год журнала: 2025, Номер 157, С. 114752 - 114752

Опубликована: Апрель 28, 2025

Язык: Английский

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1,25-Dihydroxyvitamin D3 Regulates Enteroglial Bioactivity Through Butyric Acid Pathway in a High-Fat Diet Mouse Model

Опубликована: Янв. 1, 2024

Язык: Английский

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1,25-dihydroxyvitamin D3 regulates enteroglial bioactivity through butyric acid pathway in a high-fat diet mouse model

The Journal of Steroid Biochemistry and Molecular Biology, Год журнала: 2024, Номер 247, С. 106655 - 106655

Опубликована: Дек. 6, 2024

Язык: Английский

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