The immunosuppressive role of MDSCs in HCC: mechanisms and therapeutic opportunities DOI Creative Commons
Xiling Liu,

Xichun Kang,

Haiyan Kang

и другие.

Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)

Опубликована: Март 27, 2025

Hepatocellular carcinoma (HCC) is a prevalent malignancy with significant global burden. Despite substantial advancements in HCC treatment recent years, therapeutic efficacy remains constrained by immune evasion mechanisms within the tumor microenvironment (TME). Myeloid-derived suppressor cells (MDSCs), as critical immunosuppressive elements of TME, have garnered increasing attention for their role progression. Recent studies emphasize central involvement promoting evasion, tolerance, and immunosuppression HCC. This review examines contributions MDSCs to pathogenesis, elucidates underlying mechanisms, discusses ongoing clinical trials, emphasizing potential targets improving outcomes.

Язык: Английский

Paquinimod‐hydrogel hybrid microneedle array patch alleviates hypertrophic scar via inhibiting M1 polarization DOI Creative Commons
Zi‐Hui Zhang, Peng Wang,

Hengdeng Liu

и другие.

Bioengineering & Translational Medicine, Год журнала: 2025, Номер unknown

Опубликована: Март 15, 2025

Abstract Hypertrophic scar (HS) is one of the most common complications skin injuries, with a lack effective therapeutic approaches to date. Most current research has focused on dysfunction hypertrophic fibroblasts (HSFBs) and dermal vascular endothelial cells (HDVECs), neglecting crucial role inflammatory microenvironment that causes them be abnormal. In this study, we first discovered validated S100A8/9 specific inhibitor Paquinimod could inhibit macrophage polarization toward M1, further suppress proliferation, migration, collagen formation, angiogenesis HSFBs HDVECs in vitro. This mechanism also been rat model HS. Then, developed good biocompatibility penetrability Paquinimod‐Hydrogel Hybrid Microneedle Array Patch (PHMAP) for HS treatment. With advantages excellent penetrability, surface sealing, sustained release, precise uniform distribution, PHMAP exhibited superior efficacy over intravenous intradermal injections. These results suggest can promising advanced solution prevention therapies.

Язык: Английский

Процитировано

0
The immunosuppressive role of MDSCs in HCC: mechanisms and therapeutic opportunities DOI Creative Commons
Xiling Liu,

Xichun Kang,

Haiyan Kang

и другие.

Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)

Опубликована: Март 27, 2025

Hepatocellular carcinoma (HCC) is a prevalent malignancy with significant global burden. Despite substantial advancements in HCC treatment recent years, therapeutic efficacy remains constrained by immune evasion mechanisms within the tumor microenvironment (TME). Myeloid-derived suppressor cells (MDSCs), as critical immunosuppressive elements of TME, have garnered increasing attention for their role progression. Recent studies emphasize central involvement promoting evasion, tolerance, and immunosuppression HCC. This review examines contributions MDSCs to pathogenesis, elucidates underlying mechanisms, discusses ongoing clinical trials, emphasizing potential targets improving outcomes.

Язык: Английский

Процитировано

0