Integrated metabolomics and intestinal microbiota analysis to reveal anti-post-weaning diarrhea mechanisms of Modified Yupingfeng Granule in Rex rabbits DOI Creative Commons
Dongbo Li, Chao Li,

Ning Liu

и другие.

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Апрель 10, 2025

Introduction Post-weaning Diarrhea (PWD) is a kind of physiological stress diarrhea in Rex rabbits after weaning, which can lead to death severe cases. Traditional Chinese medicine (TCM) has been widely used animal due its advantages natural origin, diverse functions, safety, reliability, economy and environmental protection. Modified Yupingfeng Granule (MYPFG) an improved prescription based on the famous traditional (YPF), combined with other TCM obvious synergistic additive activity order obtain excellent for PWD. Methods In this study, 120 weaned were randomly allocated 4 treatment groups, including control (CON), low dose (LD), medium (MD), high (HD). Rabbits fed diet or different MYPFG proportions 30 days. The study 16S rRNA analysis intestinal microbiota cecal contents metabolomics explore effect rabbits. Results increased average daily gain, villus length crypt depth ratio decreased feed meat ratio, frequency, mortality rate, ( p < 0.05). test found that could change abundances Patescibacteria, Sphingobium , Ruminococcus, Oxalobacter . Metabolomics may be related regulation Glycine, serine threonine metabolism, Arginine proline metabolism. Nicotinate nicotinamide Discussion regulate metabolic pathway some amino acids alleviate PWD

Язык: Английский

Integrated metabolomics and intestinal microbiota analysis to reveal anti-post-weaning diarrhea mechanisms of Modified Yupingfeng Granule in Rex rabbits DOI Creative Commons
Dongbo Li, Chao Li,

Ning Liu

и другие.

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Апрель 10, 2025

Introduction Post-weaning Diarrhea (PWD) is a kind of physiological stress diarrhea in Rex rabbits after weaning, which can lead to death severe cases. Traditional Chinese medicine (TCM) has been widely used animal due its advantages natural origin, diverse functions, safety, reliability, economy and environmental protection. Modified Yupingfeng Granule (MYPFG) an improved prescription based on the famous traditional (YPF), combined with other TCM obvious synergistic additive activity order obtain excellent for PWD. Methods In this study, 120 weaned were randomly allocated 4 treatment groups, including control (CON), low dose (LD), medium (MD), high (HD). Rabbits fed diet or different MYPFG proportions 30 days. The study 16S rRNA analysis intestinal microbiota cecal contents metabolomics explore effect rabbits. Results increased average daily gain, villus length crypt depth ratio decreased feed meat ratio, frequency, mortality rate, ( p < 0.05). test found that could change abundances Patescibacteria, Sphingobium , Ruminococcus, Oxalobacter . Metabolomics may be related regulation Glycine, serine threonine metabolism, Arginine proline metabolism. Nicotinate nicotinamide Discussion regulate metabolic pathway some amino acids alleviate PWD

Язык: Английский

Процитировано

0