Biological characteristics, immune infiltration and drug prediction of PANoptosis related genes and possible regulatory mechanisms in inflammatory bowel disease
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 15, 2025
PANoptosis
is
one
of
several
modes
programmed
cell
death
(PCD)
and
plays
an
important
role
in
many
inflammatory
immune
diseases.
The
bowel
disease
(IBD)
currently
unknown.
Differentially
expressed
PANoptosis-related
genes
(DE-PRGs)
were
identified,
pathway
enrichment
analyses
performed.
LASSO
regression
model
construction,
a
nomogram
model,
calibration
curves,
ROC
DCA
curves
used
to
evaluate
the
predictive
value
model.
Predicts
transcription
factors
(TFs)
small-molecule
drugs
DE-PRGs
analysed.
Model
immuno-infiltration
features
IBD
include
12
genes:
OGT,
TLR2,
GZMB,
TLR4,
PPIF,
YBX3,
CASP5,
BCL2L1,
CASP6,
MEFV,
GSDMB
BAX.
analysis
suggested
that
these
related
TNF
signalling,
NF-κB,
pyroptosis
necroptosis.
Machine
learning
identified
three
GZMB
CASP5.
have
strong
value.
Immuno-infiltration
revealed
infiltration
was
increased
patients
with
IBD,
closely
various
cells.
TFs
associated
RELA,
NFKB1,
HIF1A,
TP53
SP1.
In
addition,
Connectivity
Map
(CMap)
database
top
10
compounds,
including
buspirone,
chloroquine,
spectinomycin
chlortetracycline.
This
study
indicate
good
ability
for
IBD.
Moreover,
may
mediate
process
through
pyroptosis,
necroptosis
mechanisms.
These
results
present
new
horizon
research
treatment
Язык: Английский
The Role of Vitamin D Deficiency in Predicting Peptic Ulcer Risk
Al-Kufa University Journal for Biology,
Год журнала:
2025,
Номер
17(1), С. 83 - 92
Опубликована: Апрель 13, 2025
Peptic
ulcer
continues
to
be
a
significant
global
health
issue,
largely
due
Helicobacter
pylori
infection
and
vitamin
D
deficiency.
H.
acts
on
mucosal
damage
through
inflammation
increased
gastric
acid
secretion,
while
deficiency
compromises
immune
defenses
hinders
healing.
The
study
aimed
assess
the
impact
of
levels
as
predictive
risk
factors
for
peptic
development.
A
total
110
patients
(aged
20–65)
from
Gastroenterology
Clinic
in
Babylon
Province,
Iraq,
between
March
October
2024
were
chosen
this
cross-sectional
study;
they
categorized
based
upper
gastrointestinal
endoscopic
diagnosis
status.
strong
correlation
was
observed
PU
(p
=
0.001).
Remarkably,
(<20
ng/mL)
highly
<
0.001)
more
distributed
with
Ve+
(84.3%)
displayed
lower
(12.65
compared
Ve-
(39.0%)
17.37
0.017).
Logistic
regression
analysis
identified
independent
factor
both
(OR
8.41,
95%
CI:
3.36–21.07)
progressive
4.54,
1.92–10.72),
p
0.001.
Conclusions:
crucial
association
vulnerability
predicted
progression
risk.
screening
high-risk
groups
may
well
an
effective
strategy
preventing
Язык: Английский