Sphingosine-1-Phosphate Metabolic Pathway in Cancer: Implications for Therapeutic Targets DOI Open Access

Miguel L. Rufail,

Rosaria Bassi, Paola Giussani

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1056 - 1056

Опубликована: Янв. 26, 2025

Cancer biology revolves around understanding how cells undergo uncontrolled proliferation leading to the formation of malignant tumors. Key aspects include self-sufficiency in growth signals, lack response signals inhibition, evasion apoptosis, sustained angiogenesis, immune response, capacity invade and metastasize, alterations cellular metabolism. A vast amount research, which is exponentially growing, over past few decades highlights role sphingolipids cancer. They act not only as structural membrane components but also bioactive molecules that regulate cell fate different physio-pathological conditions. In cancer, sphingolipid metabolism dysregulated, contributing tumor progression, metastasis, drug resistance. this review, we outline impact sphingosine-1-phosphate (S1P) a key We give an overview its summarizing S1P intracellular extracellular mediator through specific plasma receptors cancers. describe previous findings on disruption balance between ceramide (Cer) common cancer can contribute tumorigenesis resistance chemotherapy. finally consider potential targeting metabolic pathways well transporters promising therapeutic approach treatments.

Язык: Английский

Sphingosine-1-Phosphate Metabolic Pathway in Cancer: Implications for Therapeutic Targets DOI Open Access

Miguel L. Rufail,

Rosaria Bassi, Paola Giussani

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1056 - 1056

Опубликована: Янв. 26, 2025

Cancer biology revolves around understanding how cells undergo uncontrolled proliferation leading to the formation of malignant tumors. Key aspects include self-sufficiency in growth signals, lack response signals inhibition, evasion apoptosis, sustained angiogenesis, immune response, capacity invade and metastasize, alterations cellular metabolism. A vast amount research, which is exponentially growing, over past few decades highlights role sphingolipids cancer. They act not only as structural membrane components but also bioactive molecules that regulate cell fate different physio-pathological conditions. In cancer, sphingolipid metabolism dysregulated, contributing tumor progression, metastasis, drug resistance. this review, we outline impact sphingosine-1-phosphate (S1P) a key We give an overview its summarizing S1P intracellular extracellular mediator through specific plasma receptors cancers. describe previous findings on disruption balance between ceramide (Cer) common cancer can contribute tumorigenesis resistance chemotherapy. finally consider potential targeting metabolic pathways well transporters promising therapeutic approach treatments.

Язык: Английский

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