Viruses, Год журнала: 2025, Номер 17(3), С. 366 - 366
Опубликована: Март 3, 2025
Acute HIV-1 infection (AHI) is a transient period where the virus causes evident damage to immune system, including an extensive apoptosis of CD4+ T cells associated with high level activation and major cytokine storm fight invading virus. HIV establishes persistence by integrating viral genome into host cell DNA in both replicating non-replicating forms, effectively hiding from surveillance within infected lymphocytes as cellular reservoirs. The measurement total peripheral blood mononuclear (PBMCs) reliable reflection this reservoir. Initiating treatments during AHI nucleoside reverse transcriptase inhibitors (NRTIs) and/or integrase strand transfer (INSTIs) essential alter dynamics global reservoir expansion, reduce establishment long-lived tissue reservoirs, while preserving enhancing specific non-specific responses. Furthermore, some patients treated at stage may become post-treatment controllers should be informative regarding mechanism control, so are undoubtedly best candidates test innovative remission strategies toward functional cure that could play pivotal role long-term control. characterized levels replication, significant increase risk transmission. Detecting initiating early treatment following diagnosis provides window opportunity control epidemic, particularly high-risk populations.
Язык: Английский