Unraveling the Potential of SGK1 in Osteoporosis: From Molecular Mechanisms to Therapeutic Targets

Biomolecules, Год журнала: 2025, Номер 15(5), С. 686 - 686

Опубликована: Май 8, 2025

Osteoporosis (OP) is a prevalent metabolic bone disease, with several million cases of fractures resulting from osteoporosis worldwide each year. This phenomenon contributes to substantial increase in direct medical expenditures and poses considerable socioeconomic burden. Despite its prevalence, our understanding the underlying mechanisms remains limited. Recent studies have demonstrated involvement serum glucocorticoid-regulated protein kinase 1 (SGK1) multiple signaling pathways that regulate metabolism significant role development osteoporosis. Therefore, it great significance deeply explore mechanism SGK1 therapeutic potential. In this paper, we present comprehensive review structure activation SGK1, biological function, different types osteoporosis, inhibitors SGK1. The aim comprehensively assess latest research progress regards SGK1’s clarify regulation potential as target, lay foundation for novel strategies personalized treatment future. Furthermore, by thoroughly examining interactions between other molecules or pathways, biomarkers may be identified, thereby enhancing efficacy early screening intervention

Язык: Английский

Challenges and future perspectives in using mesenchymal stem cells for efficient bone fracture healing

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Май 30, 2025

Mesenchymal stem cells (MSCs) demonstrate considerable potential for enhancing bone fracture healing due to their multipotency and immunomodulatory properties. This review investigates the relationship between MSCs, immune system, skeletal microenvironment, focusing on roles of cytokines signaling pathways in osteogenesis. The process fractures is complex involves a coordinated response from various cell types, including which secrete bioactive molecules that promote tissue regeneration modulate inflammation. Despite promise, challenges such as variability MSC sources, ethical considerations, regulatory restrictions, obstacles achieving effective delivery retention at sites restrict clinical application. Recent advancements MSC-based therapies, innovative biomaterials, three-dimensional bioprinting, gene editing technologies, aim improve therapeutic efficacy MSCs. In addition, strategies rejuvenate aged MSCs enhance regenerative capabilities are critical addressing age-related fractures, functionality declines with age. Understanding mechanisms underlying action, paracrine interaction essential optimizing use. Addressing existing limitations research application provides comprehensive perspective future therapies repair. discusses transformative medicine orthopedics, highlighting need further unlock full outcomes patients injuries.

Язык: Английский