Quercetin as a therapeutic agent for acute pancreatitis: a comprehensive review of antioxidant, anti-inflammatory, and immunomodulatory mechanisms
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 28, 2025
Acute
pancreatitis
(AP)
is
a
severe
inflammatory
disorder
of
the
pancreas,
characterized
by
high
morbidity
and
mortality
rates.
Despite
significant
advancements
in
understanding
pathophysiological
mechanisms
AP,
current
treatment
options
still
face
considerable
limitations.
Recent
studies
have
underscored
therapeutic
potential
quercetin,
natural
flavonoid,
due
to
its
potent
antioxidant,
anti-inflammatory,
immunomodulatory
properties,
positioning
it
as
promising
candidate
for
AP.
This
review
explores
effects
quercetin
on
highlighting
antioxidant
activities,
role
immune
modulation,
protective
pancreatic
tissue.
Furthermore,
examines
quercetin's
multi-target
advantages
over
conventional
therapies,
such
N-acetylcysteine
corticosteroids.
Although
preliminary
suggest
that
can
alleviate
inflammation
oxidative
stress
clinical
evidence
remains
limited.
One
main
challenges
application
low
bioavailability.
Future
research
should
focus
strategies
enhance
bioavailability
conducting
large-scale
randomized
controlled
trials
more
comprehensively
assess
efficacy
safety
Язык: Английский
Huashi Jiedu Decoction Enhances 5-Fluorouracil Efficacy in Gastric Cancer via miRNA-21-3p/p53 Pathway
Drug Design Development and Therapy,
Год журнала:
2025,
Номер
Volume 19, С. 3883 - 3906
Опубликована: Май 1, 2025
To
explore
the
mechanism
of
Huashi
Jiedu
Decoction
(HJD)
synergizing
with
5-fluorouracil
(5-Fu)
in
gastric
cancer
(GC)
therapy.
MicroRNAs
(miRNAs)
and
genes
involved
HJD-mediated
GC
treatment
were
identified
using
ultra-high-performance
liquid
chromatography
coupled
quadrupole-Orbitrap
mass
spectrometry,
network
pharmacology,
Gene
Ontology,
Kyoto
Encyclopedia
Genes
Genomes,
molecular
docking.
The
effects
HJD
on
5-Fu
sensitivity
BGC-823
cells
evaluated
3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium
bromide
assays,
reverse
transcription
quantitative
polymerase
chain
reaction
(RT-qPCR),
Western
blotting.
Synergistic
vector-transfected
miRNA-21-3p
knockdown
assessed
by
colony
formation,
wound
healing,
transwell
flow
cytometry
(FCM).
An
vivo
study
impact
sensitivity,
measuring
miRNA-21-3p,
tumor
protein
p53
(p53),
N-cadherin,
vimentin,
E-cadherin
tumors,
along
volume
weight.
key
targets
HJD's
therapeutic
effect
GC.
RT-qPCR
showed
that
combined
reduced
upregulated
vector
increased
mRNA
(p
<
0.01)
0.05)
compared
to
alone.
These
abolished
cells.
combination
formation
48.92%
0.01),
suppressed
migration
28.5%
inhibited
healing
81.9%
monotherapy
0.001),
no
FCM
a
15.1%
increase
G0/G1
phase
arrest
0.05).
In
vivo,
significantly
weight
18.7%,
concomitant
downregulation
0.0001),
EMT
marker
suppression
(N-cadherin,
vimentin),
suppressor
activation
(p53,
E-cadherin)
versus
enhances
5-Fu's
regulating
miRNA-21-3p/p53
pathway
modulating
cadherin
expression,
supporting
its
potential
as
an
adjunctive
Язык: Английский
Tumor-derived vesicles in immune modulation: focus on signaling pathways
Fei Yin,
Yangfang He,
Yue Qiao
и другие.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Май 15, 2025
Tumor-derived
extracellular
vesicles
(TDEVs)
represent
a
heterogeneous
population
of
(EVs),
including
exosomes,
microvesicles,
and
apoptotic
bodies,
which
are
essential
for
tumor
growth.
EVs
function
as
natural
carriers
bioactive
molecules,
lipids,
proteins,
nucleic
acids,
enabling
them
to
influence
regulate
complex
cellular
interactions
within
the
microenvironment
(TME).
The
TDEVs
mainly
have
immunosuppressive
functions
result
inhibitory
signals
disrupting
immune
cell
anti-tumor
activity.
They
enhance
progression
evasion
by
inhibiting
effector
cells
altering
critical
processes
recruitment,
polarization,
functional
suppression
different
signaling
pathways.
In
this
sense,
modulate
NF-κB
pathway,
promoting
inflammation
inducing
evasion.
Janus
kinase
(JAK)-signal
transducer
activator
transcription
(STAT)
is
required
TDEV-mediated
manifestation
tumor-supporting
features.
phosphoinositide
3-kinase
(PI3K)/protein
B
(Akt)/mammalian
target
rapamycin
(mTOR)
signaling,
necessary
metabolic
reprogramming,
orchestrated
TDEV
abrogate
response
drive
cancer
proliferation.
Finally,
exosomal
cargo
can
NOD-,
LRR-,
pyrin
domain-containing
protein
3
(NLRP3)
inflammasome,
activating
pro-inflammatory
responses
that
development
immunomodulation.
review,
we
take
deep
dive
into
how
affect
key
We
also
examine
emerging
therapeutic
approaches
aimed
at
EV-mediated
pathways,
offering
promising
avenues
novel
EV-based
immunotherapy.
Язык: Английский
Tumor-Associated Macrophages: Polarization, Immunoregulation, and Immunotherapy
Cells,
Год журнала:
2025,
Номер
14(10), С. 741 - 741
Опубликована: Май 19, 2025
Tumor-associated
macrophages’
(TAMs)
origin,
polarization,
and
dynamic
interaction
in
the
tumor
microenvironment
(TME)
influence
cancer
development.
They
are
essential
for
homeostasis,
monitoring,
immune
protection.
Cells
from
bone
marrow
or
embryonic
progenitors
dynamically
polarize
into
pro-
anti-tumor
M2
M1
phenotypes
based
on
cytokines
metabolic
signals.
Recent
advances
TAM
heterogeneity,
characterization,
immunological
responses,
therapy
described
here.
The
manuscript
details
functions
their
role
resistance
to
PD-1/PD-L1
blockade.
Similarly,
TAM-targeted
approaches,
such
as
CSF-1R
inhibition
PI3Kγ-driven
reprogramming,
discussed
address
immunity
suppression.
Furthermore,
innovative
biomarkers
combination
may
enhance
TAM-centric
therapies.
It
also
stresses
relevance
of
this
distinct
cell
human
health
disease,
which
could
impact
future
research
Язык: Английский