Emerging Trends in Biosensor and Microfluidics Integration for Inner Ear Theragnostics DOI Creative Commons
Behrouz Aghajanloo, Simin Nazarnezhad,

Faezeh Arshadi

и другие.

Biosensors and Bioelectronics, Год журнала: 2025, Номер 286, С. 117588 - 117588

Опубликована: Май 15, 2025

Advancements in inner ear theragnostics are critical for addressing the pervasive challenges of diagnosing and treating hearing balance disorders, which significantly impact quality life. This paper reviews biosensors devices that leverage advanced functional nanomaterials, microfabrication techniques, nano-biotechnology to enhance theragnostic applications ear. The highlights development diverse electromechanical, electrochemical, biomarker sensors theragnostics. Electromechanical replicate cochlear vestibular sensory structures through bioinspired designs, while electrochemical used measure level ions chemicals fluid, providing insights into health disease organs. Biomarker focus on screening diseases early detection correlated biomarkers based point care diagnostics. study also examines use microfluidic with elements provide a compact integrated model fluid-filled cochlea. In addition, delivery strategies, including targeted drug systems nanocarriers explored their ability improve penetration distribution therapeutics within importance pharmacokinetics post-treatment monitoring as indicators assessing efficacy micro/nanotechnology-based approaches. By consolidating these innovations, this work offers comprehensive framework advancing otology, paving way novel diagnostic tools, effective treatments, future clinical applications.

Язык: Английский

Self‐Powered Nanostructured Piezoelectric Filaments as Advanced Transducers for New Cochlear Implants DOI Creative Commons
Fatemeh Mokhtari, Serena Danti, Bahareh Azimi

и другие.

Energy & environment materials, Год журнала: 2024, Номер unknown

Опубликована: Июль 25, 2024

The conversion of sound vibration into electrical potential is a critical function performed by cochlear hair cells. Unlike the regenerative capacity found in various other cells throughout body, sensory lack ability to regenerate once damaged. Furthermore, decline quantity these results deterioration auditory function. Piezoelectric materials can generate electric charge response wave vibration, making them theoretically suitable for replacing cell This study explores an innovative approach using piezoelectric nanocomposite filaments, namely poly(vinylidene fluoride), fluoride)/barium titanate, and fluoride)/reduced graphene oxide, as self‐powered acoustic sensors designed place These flexible filaments demonstrate unique electricity frequency sounds from 50 up 1000 Hz at moderate pressure levels (60–95 dB), approaching audible range with overall acoustoelectric energy efficiency 3.25%. Serving sensors, hold promise applications implants, high sensitivity 117.5 mV (Pa·cm 2 ) −1 . cytocompatibility was assessed through vitro viability tests conducted on three lines, serving model inner ear

Язык: Английский

Процитировано

12
Emerging Trends in Biosensor and Microfluidics Integration for Inner Ear Theragnostics DOI Creative Commons
Behrouz Aghajanloo, Simin Nazarnezhad,

Faezeh Arshadi

и другие.

Biosensors and Bioelectronics, Год журнала: 2025, Номер 286, С. 117588 - 117588

Опубликована: Май 15, 2025

Advancements in inner ear theragnostics are critical for addressing the pervasive challenges of diagnosing and treating hearing balance disorders, which significantly impact quality life. This paper reviews biosensors devices that leverage advanced functional nanomaterials, microfabrication techniques, nano-biotechnology to enhance theragnostic applications ear. The highlights development diverse electromechanical, electrochemical, biomarker sensors theragnostics. Electromechanical replicate cochlear vestibular sensory structures through bioinspired designs, while electrochemical used measure level ions chemicals fluid, providing insights into health disease organs. Biomarker focus on screening diseases early detection correlated biomarkers based point care diagnostics. study also examines use microfluidic with elements provide a compact integrated model fluid-filled cochlea. In addition, delivery strategies, including targeted drug systems nanocarriers explored their ability improve penetration distribution therapeutics within importance pharmacokinetics post-treatment monitoring as indicators assessing efficacy micro/nanotechnology-based approaches. By consolidating these innovations, this work offers comprehensive framework advancing otology, paving way novel diagnostic tools, effective treatments, future clinical applications.

Язык: Английский

Процитировано

0