Molecular Biology Reports, Год журнала: 2025, Номер 52(1)
Опубликована: Фев. 20, 2025
Язык: Английский
Nature Reviews Rheumatology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Язык: Английский
Процитировано
0
PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0317517 - e0317517
Опубликована: Янв. 13, 2025
This study examined the correlation between circulating receptor activator for nuclear factor-κB ligand (RANKL) levels and rheumatoid arthritis (RA), investigated association polymorphisms in RANKL gene susceptibility to RA. We searched Medline, Embase, Cochrane databases relevant publications up September 2024. A meta-analysis was conducted assess serum/plasma patients with RA controls, explore relationship rs9533156 rs2277438 susceptibility. Ten studies encompassing 1,682 1,288 controls were analyzed. significantly higher compared (SMD = 0.665, 95% CI 0.290-1.040, P 0.001). Subgroup analysis affirmed these findings' consistency across different sample sizes publication years. positively associated factor (RF) Disease Activity Score-28 (DAS28) (RF coefficient 0.157, 0.028-0.282, 0.018; DAS28 0.151, 0.125-0.370, < Additionally, revealed significant associations C allele (OR 0.609, 0.520-0.714, 0.010) as well G 1.206, 1.003-1.451, 0.047). These consistent homozygote comparisons genetic models. underscores elevated their RF DAS28.
Язык: Английский
Процитировано
0
Antioxidants, Год журнала: 2025, Номер 14(2), С. 171 - 171
Опубликована: Янв. 31, 2025
Rheumatoid arthritis (RA) is a long-term systemic autoimmune disorder that causes joint inflammation, swelling, pain, bone erosion, and deformities. Recent findings emphasize the anti-inflammatory antioxidant properties of bioactive natural compounds, such as polyphenols extracted from plants fruits, their possible synergistic effect when used in combination with current therapies to improve prognosis symptoms inflammatory rheumatic diseases. Here, we report Sicilian extra virgin olive oil polyphenol-enriched extracts (PE-EVOOs) reduce intracellular reactive oxygen species (ROS) pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α) interleukin-1 β (IL-1β), peripheral mononuclear cells (PBMCs) obtained both RA patients healthy subjects (HSs) treated lipopolysaccharides (LPS) control. HPLC-ESI-MS analysis highlighted PE-EVOOs are rich different polyphenolic compounds responsible for many observed biological effects. At molecular levels, Western blotting analyses revealed PE-EVOO treatment associated downregulation phosphorylated active form transcription factor NF-κB enzyme cyclooxygenase 2 (COX2). In addition, upregulated Nrf2 its target catalase manganese superoxide dismutase (MnSOD). Collectively, these results suggest use potential adjuvants RA.
Язык: Английский
Процитировано
0
Journal of Psychosomatic Research, Год журнала: 2025, Номер 191, С. 112061 - 112061
Опубликована: Фев. 11, 2025
Язык: Английский
Процитировано
0
International Journal of Rheumatic Diseases, Год журнала: 2025, Номер 28(2)
Опубликована: Фев. 1, 2025
Rheumatoid arthritis (RA) is an autoimmune disease that marked by inflammatory response. PNPLA2 (phospholipase patatin-like) which encodes ATGL (adipose triglyceride lipase) also been identified as playing in inflammation. G0S2 (G0/G1) switch gene has one of the selective inhibitors ATGL. and may be factors can help predict relationship between molecules affecting inflammation, well identify pathways through genes involved metabolic pathway. In present study, we analyzed expression levels their protein concentrations real-time PCR immunoassay, respectively on 60 peripheral blood mononuclear cells (PBMC) are included into 3 different groups new case patients with RA, chronic control individuals. Also, to obtain more accurate information results, synovial fluid, triglyceride, cholesterol, ESR were analyzed. Statistical analysis was then performed software SPSS-18. level significantly increased newly diagnosed RA compared group. serum reduced The elevated other groups, but interestingly this increase PBMCs not significant. This predicted only regulated gene, regulatory affect immune cells.
Язык: Английский
Процитировано
0
Pharmacological Research - Modern Chinese Medicine, Год журнала: 2025, Номер unknown, С. 100597 - 100597
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Deleted Journal, Год журнала: 2025, Номер unknown
Опубликована: Март 10, 2025
Процитировано
0
Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 27
Опубликована: Март 20, 2025
Rheumatoid Arthritis (RA), an autoimmune disease, is a chronic inflammatory disorder affecting the joints leading to severe damage and cartilage destruction. Current therapies for RA such as DMARDs, NSAIDs, glucocorticoids, phytoconstituents often face challenges related solubility transdermal permeability. Considering barriers posed by stratum corneum in drug delivery, ethosomes have shown promising results overcoming these hurdles. The presence of ethanol imparts flexibility disrupts skin's lipid bilayer, allowing penetration. Researchers explored potential ethosomal delivery systems loaded with various synthetic drugs management RA. Despite preclinical findings, yet transition from bench bedside, there lack comprehensive review papers highlighting treatment. commercial scaling up nano systems, this aims analyse current state art advancements formulations agents phytoconstituents. Further, it explores impact excipients processing parameters, on preparation their efficacy skin barriers, enhance permeability therapeutic agents.
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Март 28, 2025
Rheumatoid arthritis (RA) is a global epidemic. We conducted cross-sectional study using the Global Burden of Disease (GBD) 2021 dataset to examine RA trends in patients aged 20-54 years worldwide. Key outcomes included incidence, mortality, and disability-adjusted life (DALYs), as well over time, stratifying by region, country, age, sex, Sociodemographic Index (SDI). also assessed contribution smoking RA-related mortality DALYs. Over past 32 years, incidence rate increased from 11.66 (95% UI 9.60-13.94) 13.48 11.08-16.06) per 100,000 population. DALYs 26.37 18.43-36.99) 30.71 20.82-44.08) population, with females bearing higher burden. And decreased 0.09 0.08-0.1) 0.06 0.05-0.07) Regional disparities were evident, lower SDI regions experiencing larger change. Smoking remained significant risk factor, accounting for 9.01% 2021. Overall, we highlighted rising burden RA, particularly among regions, emphasizing healthcare resources, prevention, early diagnosis.
Язык: Английский
Процитировано
0
Metabolites, Год журнала: 2022, Номер 12(5), С. 394 - 394
Опубликована: Апрель 27, 2022
Metabolomic analysis provides a wealth of information that can be predictive distinctive phenotypes pathogenic processes and has been applied to better understand disease development. Rheumatoid arthritis (RA) is an autoimmune with the establishment chronic synovial inflammation affects joints peripheral tissues such as skeletal muscle bone. There lack useful biomarkers track activity, drug response follow-up in RA. In this review, we describe potential metabolic might helpful study RA pathogenesis, risk comorbidities. TMAO (choline trimethylamine oxide) TCA (tricarboxylic acid) cycle products have suggested modulate profiles during early stages are present systemically, which relevant characteristic for biomarkers. Moreover, lipids cholesterol, FFAs PUFAs may provide important before onset predict activity treatment response. Regarding therapeutics, TNF inhibitors increase levels tryptophan, valine, lysine, creatinine alanine, whereas JAK/STAT exclusively fatty acids. These observations indicate different modifying antirheumatic drugs specific reveal differences between responders non-responders. terms comorbidities, physical impairment represented by higher fatigue scores wasting associated urea cycle, FFAs, tocopherols BCAAs. conclusion, fluid, blood urine samples from patients seem critical about profile related response,
Язык: Английский
Процитировано
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