Abstract
Impaired
cerebrovascular
function
contributes
to
the
genesis
of
age‐related
cognitive
decline.
In
this
study,
hypothesis
is
tested
that
impairments
in
neurovascular
coupling
(NVC)
responses
and
brain
network
predict
dysfunction
older
adults.
Cerebromicrovascular
working
memory
healthy
young
(
n
=
21,
33.2±7.0
years)
aged
30,
75.9±6.9
participants
are
assessed.
To
determine
NVC
functional
connectivity
(FC)
during
a
(n‐back)
paradigm,
oxy‐
deoxyhemoglobin
concentration
changes
from
frontal
cortex
using
near‐infrared
spectroscopy
recorded.
significantly
impaired
2‐back
task
participants,
while
networks
characterized
by
higher
local
global
connection
strength,
dynamic
FC
p
<
0.05).
Both
increased
correlate
with
decline
accuracy
task.
These
findings
suggest
task‐related
states
adults
require
stronger
connections
compensate
for
attenuated
associated
load.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(22), С. 16518 - 16518
Опубликована: Ноя. 20, 2023
Endothelial
cells
lining
blood
vessels
are
essential
for
maintaining
vascular
homeostasis
and
mediate
several
pathological
physiological
processes.
Mechanical
stresses
generated
by
flow
other
biomechanical
factors
significantly
affect
endothelial
cell
activity.
Here,
we
review
how
mechanical
stresses,
both
in
situ
vitro,
cells.
We
the
basic
principles
underlying
cellular
response
to
stresses.
also
consider
implications
of
these
findings
understanding
mechanisms
mechanotransducer
mechano-signal
transduction
systems
cytoskeletal
components.
Current Heart Failure Reports,
Год журнала:
2024,
Номер
21(4), С. 322 - 336
Опубликована: Июнь 11, 2024
Abstract
Purpose
of
Review
We
summarise
the
physiological
changes
and
risk
factors
for
hypertension
in
females,
potential
sex-specific
management
approaches,
long-term
prognosis.
Key
Findings
Pregnancy
menopause
are
two
key
phases
life
cycle
where
females
undergo
significant
biological
physical
changes,
making
them
more
prone
to
developing
hypertension.
Gestational
occurs
from
maternal
cardiac
output,
kidney
function,
metabolism,
or
placental
vasculature,
with
one
ten
experiencing
pregnancy
complications
such
as
intrauterine
growth
restriction
delivery
premature
birth.
Post-menopausal
protective
effects
oestrogen
reduced
sympathetic
nervous
system
becomes
over-activated
ageing.
Increasing
evidence
suggests
that
post-menopausal
high
blood
pressure
(BP)
experience
greater
cardiovascular
events
at
lower
BP
thresholds,
vulnerability
treatment-related
adverse
effects.
Summary
Hypertension
is
a
factor
disease
females.
Current
treatment
guidelines
recommendations
similar
both
sexes,
without
addressing
factors.
Future
investigations
into
ideal
diagnostic
control
targets
regimens
needed.
Abstract
Impaired
cerebrovascular
function
contributes
to
the
genesis
of
age‐related
cognitive
decline.
In
this
study,
hypothesis
is
tested
that
impairments
in
neurovascular
coupling
(NVC)
responses
and
brain
network
predict
dysfunction
older
adults.
Cerebromicrovascular
working
memory
healthy
young
(
n
=
21,
33.2±7.0
years)
aged
30,
75.9±6.9
participants
are
assessed.
To
determine
NVC
functional
connectivity
(FC)
during
a
(n‐back)
paradigm,
oxy‐
deoxyhemoglobin
concentration
changes
from
frontal
cortex
using
near‐infrared
spectroscopy
recorded.
significantly
impaired
2‐back
task
participants,
while
networks
characterized
by
higher
local
global
connection
strength,
dynamic
FC
p
<
0.05).
Both
increased
correlate
with
decline
accuracy
task.
These
findings
suggest
task‐related
states
adults
require
stronger
connections
compensate
for
attenuated
associated
load.
