To
this
day,
use
of
oily
eye
drops
and
non-invasive
retinal
delivery
remains
a
major
challenge.
Oily
usually
cause
ocular
irritation
interfere
with
normal
function
the
eye,
while
injections
for
drug
significant
adverse
effects
high
burden
on
healthcare
system.
Here
authors
report
novel
topical
Non-Invasive
Ocular
Delivery
Platform
(NIODP)
through
periorbital
skin
efficiency
anterior
posterior
in
non-human
primate
model
(NHP).
A
single
dose
about
7mg
JV-MD2
(omega-3
DHA)
via
NIODP
reached
retina
at
Cmax
111µg/g
cornea
66µg/g.
also
delivered
JV-DE1,
an
anti-inflammatory
agent
development
dry
diseases,
as
efficiently
did
to
segments
NHP.
The
seems
transport
candidates
pathway
conjunctiva/sclera
eye.
method
has
potential
reshape
landscape
delivery,
especially
where
success
treatment
lies
tolerability
bioavailability
drugs
target
tissue.
Pharmaceutics,
Год журнала:
2023,
Номер
15(9), С. 2344 - 2344
Опубликована: Сен. 19, 2023
To
this
day,
the
use
of
oily
eye
drops
and
non-invasive
retinal
delivery
remain
a
major
challenge.
Oily
usually
cause
ocular
irritation
interfere
with
normal
functioning
eye,
while
injections
for
drug
significant
adverse
effects
high
burden
on
healthcare
system.
Here,
authors
report
novel
topical
platform
(NIODP)
through
periorbital
skin
high-efficiency
anterior
posterior
in
non-human
primate
model
(NHP).
A
single
dose
about
7
mg
JV-MD2
(omega
3
DHA)
was
delivered
via
NIODP
reached
retina
at
Cmax
111
µg/g
cornea
66
µg/g.
The
also
JV-DE1,
an
anti-inflammatory
agent
development
dry
diseases,
as
efficiently
did
to
segments
NHP.
seems
transport
candidates
corneal
pathway
conjunctiva/sclera
eye.
method
has
potential
reshape
landscape
delivery.
This
is
especially
case
delivery,
where
success
treatment
lies
tolerability
bioavailability
drugs
target
tissue.
The
chapter
provides
an
analysis
of
the
diverse
range
sensory
experiences
and
challenges
in
addressing
them
with
current
technology.
Opening
a
discussion
on
how
cultural
spiritual
beliefs
shape
perceptions,
uses
insights
from
various
cultures,
including
Berinmo
people.
It
then
delves
into
aesthetic
disabilities
beyond
visual
perception,
such
as
face
blindness,
dyschromatopsia,
dyscalculia,
synesthesia,
exploring
their
unique
impacts
artistic
interpretation.
also
tackles
cross-modal
challenges,
highlighting
conditions
like
anosmia
agnosia,
implications
for
experiencing
art.
Emphasizing
neurodiversity,
it
examines
neurodivergent
individuals,
particularly
those
spectrum,
have
distinct
preferences
responses
to
Aphantasia's
role
experience
is
discussed,
absence
mental
imagery
influences
art
perception
creation.
Finally,
identifies
key
gaps
technological
applications,
discussing
issues
ableism
technologies
need
more
inclusive
adaptable
tools.
concludes
by
therapeutic
adaptive
color
therapy
adaptations
museums,
emphasizing
importance
developing
that
cater
broad
spectrum
preferences.
This
crucial
intricate
relationship
between
experiences,
technology
enhancing
engagement.
Diabetes
and
diabetes-induced
micro
macrovascular
complications
are
major
causes
of
healthcare
problems.
The
extracellular
vesicles
produced
by
all
cells
from
organisms.
They
shown
to
have
properties
the
producer
also
reflect
host
physiology
pathology.
Since
EVs
represent
cellular
state
they
excellent
biomarkers.
In
this
review,
we
will
focus
on
Neuro
Vascular
Unit
eye
as
well
extraocular
in
onset
progression
diabetic
retinopathy.
A
brief
account
use
these
nanovesicles
personalised
medicine
is
given.
To
this
day,
use
of
oily
eye
drops
and
non-invasive
retinal
delivery
remains
a
major
challenge.
Oily
usually
cause
ocular
irritation
interfere
with
normal
function
the
eye,
while
injections
for
drug
significant
adverse
effects
high
burden
on
healthcare
system.
Here
authors
report
novel
topical
Non-Invasive
Ocular
Delivery
Platform
(NIODP)
through
periorbital
skin
efficiency
anterior
posterior
in
non-human
primate
model
(NHP).
A
single
dose
about
7mg
JV-MD2
(omega-3
DHA)
via
NIODP
reached
retina
at
Cmax
111µg/g
cornea
66µg/g.
also
delivered
JV-DE1,
an
anti-inflammatory
agent
development
dry
diseases,
as
efficiently
did
to
segments
NHP.
The
seems
transport
candidates
pathway
conjunctiva/sclera
eye.
method
has
potential
reshape
landscape
delivery,
especially
where
success
treatment
lies
tolerability
bioavailability
drugs
target
tissue.
