Boosting Cancer Cell Uptake of Gold Nanoparticles by Light-Modulated Protein Corona Reorganization for Tumor Ablation
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Nanoparticles
(NPs)
administered
into
the
human
body
are
spontaneously
modified
by
forming
a
protein
corona,
which
is
crucial
for
their
biological
activity.
While
NP-based
photothermal
therapy
an
established
noninvasive
modality
tumor
ablation,
impact
of
light
irradiation
on
corona
formation
and
clinical
outcomes
unclear.
This
study
unveils
promotive
role
in
cancer
cell
uptake
gold
nanoparticles
(GNPs)
modulating
GNP-protein
protein-protein
interactions
within
corona.
Specifically,
infrared
increases
local
temperature
around
GNPs
to
induce
partial
unfolding
proteins,
increasing
availability
binding
sites
enhancing
adsorption.
Additionally,
intensifies
competition
among
different
proteins
adsorption,
resulting
25%
increase
abundance
higher
molecular
weight
such
as
serum
albumin
(HSA),
GNP
surface
after
irradiation.
Notably,
with
positively
charged
surfaces,
compared
other
modifications,
exhibit
more
significant
changes
due
stronger
electrostatic
(1.32
±
0.17
×
103
kJ/mol).
These
variations
amount,
structure,
composition
associated
result
14.26%
cells,
likely
modifications
at
GNP-cell
membrane
interface.
Our
findings
highlight
critical
influencing
dynamics
cellular
interactions,
suggesting
its
potential
valuable
engineering
tool
nanomedicine.
Язык: Английский
Neurotoxicity and Biosafety of Nanomaterials
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 1 - 26
Опубликована: Окт. 11, 2024
This
chapter
explores
the
neurotoxicity
of
nanomaterials,
focusing
on
their
potential
to
induce
harmful
effects
central
nervous
system.
Nanomaterials,
with
dimensions
between
1
and
100
nanometers,
possess
unique
properties
that
make
them
valuable
in
various
industries.
However,
ability
penetrate
brain
through
different
pathways
raises
concerns
about
neurotoxicity.
Studies
have
highlighted
adverse
nanomaterial
exposure,
including
oxidative
stress,
inflammation,
gene
expression
alterations.
Understanding
mechanisms
factors
influencing
is
crucial
for
ensuring
safe
use
across
diverse
applications.
Язык: Английский