Metrology for MRI: the field you’ve never heard of
Magnetic Resonance Materials in Physics Biology and Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Quantitative
MRI
has
been
an
active
area
of
research
for
decades
and
produced
a
huge
range
approaches
with
enormous
potential
patient
benefit.
In
many
cases,
however,
there
are
challenges
reproducibility
which
have
hampered
clinical
translation.
is
form
measurement
like
any
other
it
requires
supporting
metrological
framework
to
be
fully
consistent
compatible
the
international
system
units.
This
means
not
just
expressing
results
in
terms
seconds,
meters,
etc.,
but
demonstrating
consistency
their
internationally
recognized
definitions.
Such
yet
complete,
considerable
amount
work
done
towards
building
one.
article
describes
current
state
art
metrology,
including
detailed
description
principles
how
they
relevant
quantitative
MRI.
It
also
undertakes
gap
analysis
where
we
versus
need
support
focusses
particularly
on
role
activities
national
institutes
across
globe,
illustrating
genuinely
collaborative
nature
field.
Язык: Английский
[18F]F-AraG Uptake in Vertebral Bone Marrow May Predict Survival in Patients with Non–Small Cell Lung Cancer Treated with Anti-PD-(L)1 Immunotherapy
Journal of Nuclear Medicine,
Год журнала:
2024,
Номер
unknown, С. jnumed.124.268253 - jnumed.124.268253
Опубликована: Окт. 24, 2024
Despite
the
systemic
impact
of
both
cancer
and
associated
immune
response,
immuno-PET
is
predominantly
centered
on
assessment
milieu
within
tumor
microenvironment.
The
aim
this
study
was
to
assess
value
[18F]F-AraG
PET
imaging
as
a
noninvasive
method
for
evaluation
system-wide
status
patients
with
non–small
cell
lung
before
starting
immunotherapy.
Methods:
Eleven
advanced
were
imaged
Diagnostic
[18F]FDG
PET/CT
scans
analyzed
differences
in
extent
disease
among
patients.
SUVmax,
SUVmean,
total
SUV
(SUVtotal)
from
all
lesions,
active
lymph
nodes,
spleen,
vertebral
bone
marrow,
liver,
thyroid,
heart,
bowel
extracted
baseline
scans,
discriminant
Kaplan–Meier
analyses
performed
test
their
ability
predict
patient
response
overall
survival.
Results:
variable
cohort,
but
none
biomarkers
burden
(SUVmax,
metabolic
volume,
lesion
glycolysis)
predictive
distribution
observed
between
confirming
that
they
capture
distinct
aspects
Of
3
parameters
studied,
SUVtotal
provided
dynamic
range
suitable
stratifying
tumors
or
according
activity.
measured
lumbar
sacral
vertebrae
differentiated
who
progressed
therapy
those
did
not
90.9%
81.8%
accuracy,
respectively.
analysis
revealed
high
marrow
had
significantly
lower
probability
survival
than
low
signal
(P
=
0.0003).
Conclusion:
This
highlights
significance
assessing
immunity
indicates
potential
biomarker
stratification
treatment
guidance.
Язык: Английский
Physiological markers for immunotherapeutics: a review
Journal of Chemotherapy,
Год журнала:
2024,
Номер
unknown, С. 1 - 24
Опубликована: Дек. 22, 2024
Immunotherapy
has
been
advanced
through
multiple
approaches,
including
immunogenic
cytokines,
monoclonal
antibodies,
therapeutic
vaccinations,
adoptive
cell
transfer,
stem
transplantation,
and
oncolytic
viruses.
This
review
analyses
various
strategies
in
genomics,
transcriptomics,
single-cell
techniques,
computational
analysis,
big
data,
imaging
technologies
for
the
identification
of
tumour
microbiota
microenvironments.
is
becoming
acknowledged
as
a
feasible
cancer
treatment
method,
facilitating
innovative
medicines
personalized
medicine
techniques.
Язык: Английский