Hair Longevity—Evidence for a Multifactorial Holistic Approach to Managing Hair Aging Changes
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(6), С. 1894 - 1894
Опубликована: Март 11, 2025
Loss
of
hair
density—hair
thinning
and
balding—
is
typically
referred
to
as
male
female
pattern
alopecia.
Causes
include
genetic
predisposition
links
the
impact
dihydrotestosterone
on
follicle
dermal
papilla,
which
are
characterized
by
an
increase
in
number
vellus
follicles.
Links
chronological
aging
unclear.
Proven
treatments
remain
few
still
targeting
tested
those
experiencing
classical
loss.
The
way
changes
with
aging,
especially
women,
can
be
considered
having
a
much
broader
scope.
Trends
managing
density,
length,
fiber
quality
now
mostly
cocktail
approaches—whether
topical,
injected,
or
oral—recognizing
that
solutions
more
likely
require
multifactorial
strategy.
This
review
examines
evidence
for
holistic
approach
addressing
unwanted
loss,
includes
nutrition,
lifestyle,
stress
management,
scalp
care,
well
co-morbidities
other
health
concerns.
We
discuss
strengths
limitations
clinical
study
design
investigate
efficacy
using
approaches.
propose
this
strategy
will
contribute
emerging
concept
longevity
follicle,
scalp,
targeted
maintaining
anagen
most
appropriate
route
achieving
healthy
aging.
Finally,
we
problem
facing
patients
consumers
regarding
quantity
misinformation
how
it
influences
choosing
from
fast-growing
market
bypass
pharmaceutical
thinning.
Язык: Английский
Unveiling a novel in-vitro model of skin inflammaging
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Март 28, 2025
Sensitive
skin
is
characterized
by
a
disrupted
barrier,
making
it
prone
to
reacting
external
stimuli,
including
UV
exposure,
air
pollution,
and
cosmetic
allergens.
tends
react
with
oxidative
stress
factors
that
could
further
lead
inflammation
subsequently
result
in
inflammaging.
However,
there
are
almost
no
existing
inflammaging
models
specifically
for
sensitive
skin,
highlighting
the
need
develop
method
screening
anti-inflammaging
ingredients
products.
An
vitro
macrophage-fibroblast
model
was
established
evaluate
effects
of
ingredients.
The
M1
phenotype
aging-associated
gene
expression
were
assessed
using
qPCR
validate
model.
RNA
sequencing
used
elucidate
mechanisms
two
validated
A
novel
in-vitro
developed
applying
supernatant
macrophage
culture
medium
induce
cellular
senescence
fibroblast
cells,
facilitating
In
this
model,
supramolecular
bakuchiol
promote
collagen
COL1A1
COL3A3
production
inhibit
inflammatory
enhancing
transcription
anti-inflammatory
genes
(PTX3,
ADAM33,
PDLIM1),
while
Terminalia
chebula
extract
inhibits
cell
reducing
MAP4K2
accumulation
factor
CCL3.
Язык: Английский
Promoting collagen synthesis: a viable strategy to combat skin ageing
Journal of Enzyme Inhibition and Medicinal Chemistry,
Год журнала:
2025,
Номер
40(1)
Опубликована: Апрель 11, 2025
Skin
ageing
is
a
complex
physiological
process
primarily
characterised
by
the
deepening
of
wrinkles
and
sagging
skin.
Collagen
essential
for
maintaining
skin
elasticity
firmness.
As
ages,
it
experiences
structural
functional
changes
in
collagen,
including
decrease
collagen
synthesis
an
increase
hydrolysis.
Thus,
promoting
represents
practical
strategy
mitigating
ageing.
This
review
systematically
described
functions,
classifications
biosynthesis
as
well
its
role
Additionally,
major
signalling
pathways
targets
associated
with
were
also
discussed.
More
importantly,
provided
detailed
summary
natural
products
synthesis-promoting
effects
highlighted
small
molecule
compounds
potential
anti-ageing
activity,
especially
PPARδ
agonists.
The
relevant
content
offers
lead
development
anti-skin
therapies.
Язык: Английский
Patients With Rosacea Exhibit Lower Minimal Erythema Doses to Both UVA and UVB
Photodermatology Photoimmunology & Photomedicine,
Год журнала:
2025,
Номер
41(3)
Опубликована: Апрель 14, 2025
ABSTRACT
Background
Rosacea,
a
prevalent
chronic
inflammatory
skin
condition
primarily
affecting
the
central
facial
convexities,
is
categorized
into
four
clinical
subtypes:
erythematotelangiectatic
rosacea
(ETR),
papulopustular
(PPR),
phymatous
(PhR),
ocular
(OR).
While
ultraviolet
(UV)
radiation
recognized
as
risk
factor
for
rosacea,
differential
sensitivity
to
UVA
and/or
UVB
between
healthy
individuals
and
patients
remains
ambiguous.
Methods
This
study
comprised
70
diagnosed
with
100
controls.
The
minimal
erythema
doses
(MED‐UVA
MED‐UVB)
were
ascertained
using
an
SUV‐2000
solar
UV
simulator.
A
comparative
analysis
was
conducted
on
MED‐UVA
MED‐UVB
results
patient
group
control
group,
well
among
varying
subtypes.
Furthermore,
correlation
MED
values
in
factors
such
age,
type,
antinuclear
antibodies
(ANA),
Clinical
Erythema
Assessment
(CEA)
scale
evaluated.
Results
In
comparison
demonstrated
significantly
lower
(
p
<
0.05)
≤
0.001)
values.
However,
no
significant
differences
observed
>
subtypes
of
specifically
ETR
PPR.
Conclusion
Patients
demonstrate
decreased
dose
both
UVB,
suggesting
heightened
radiation.
Consequently,
it
advisable
minimize
sun
exposure
order
mitigate
or
prevent
exacerbation
condition.
Язык: Английский
Exploring the Evolution of Senotherapeutics Across Generations: A New Era in Human Dermal Fibroblast Senotherapy
Journal of Skin and Stem Cell,
Год журнала:
2025,
Номер
12(1)
Опубликована: Март 28, 2025
Background:
The
skin,
as
the
body’s
largest
organ,
plays
a
crucial
role
in
systemic
physiological
processes.
Dysfunction
often
driven
by
cellular
senescence,
accelerates
skin
aging
and
contributes
to
aging.
accumulation
of
senescent
cells
secretion
senescence-associated
secretory
phenotype
(SASP)
factors
are
central
mechanisms
underlying
aging,
particularly
affecting
dermal
fibroblasts,
which
key
producers
collagen
elastin.
Given
these
challenges,
senotherapy
has
emerged
promising
strategy
mitigate
specifically
targeting
cells.
Objectives:
present
study
evaluates
therapeutic
potential
advanced
senotherapeutics
critical
for
maintaining
structure
function.
It
highlights
integration
cutting-edge
technologies,
including
targeted
nanoparticles,
chimeric
antigen
receptor
T
(CAR-T)
cells,
artificial
intelligence,
gene
editing,
address
cell
heterogeneity
improve
outcomes.
Methods:
Various
senotherapeutics,
senolytic
agents
eliminating
senomorphic
modulating
SASP,
were
assessed.
Advanced
technologies
such
CAR-T
editing
evaluated
their
ability
enhance
specificity
reduce
off-target
effects.
focused
on
efficacy
fibroblasts
inflammatory
markers
associated
with
SASP.
Preclinical
vitro
models
used
test
approaches.
Results:
demonstrated
significant
improvements
selectively
while
minimizing
These
therapies
effectively
modulated
leading
reduced
an
enhanced
environment
health.
By
addressing
challenges
heterogeneity,
approaches
showcased
superior
precision
compared
earlier
generations,
emphasizing
mitigating
both
Conclusions:
findings
highlight
its
implications.
Through
precise
effective
modulation
offer
transformative
improving
health
combating
broader
age-related
challenges.
incorporation
marks
advancement
pursuit
innovative
anti-aging
solutions.
Язык: Английский
Innovative Solid Lipid Nanoparticle-Enriched Hydrogels for Enhanced Topical Delivery of L-Glutathione: A Novel Approach to Anti-Ageing
Pharmaceutics,
Год журнала:
2024,
Номер
17(1), С. 4 - 4
Опубликована: Дек. 24, 2024
Background:
Skin
ageing,
driven
predominantly
by
oxidative
stress
from
reactive
oxygen
species
(ROS)
induced
environmental
factors
like
ultraviolet
A
(UVA)
radiation,
accounts
for
approximately
80%
of
extrinsic
skin
damage.
L-glutathione
(GSH),
a
potent
antioxidant,
holds
promise
in
combating
UVA-induced
stress.
However,
its
instability
and
limited
penetration
through
the
stratum
corneum
hinder
topical
application.
This
study
introduces
novel
solid
lipid
nanoparticle
(SLN)-enriched
hydrogel
designed
to
enhance
GSH
stability,
penetration,
sustained
release
anti-ageing
applications.
Methods:
GSH-loaded
SLNs
were
prepared
via
double-emulsion
technique
optimized
using
factorial
design.
These
incorporated
into
1-3%
(w/v)
Carbopol
hydrogels
produce
semi-solid
formulation.
The
hydrogel's
characteristics,
including
morphology,
mechanical
rheological
properties,
drug
release,
antioxidant
activity,
cytotoxicity,
evaluated.
Results:
SEM
FTIR
confirmed
uniform
dispersion
within
hydrogel.
formulation
exhibited
desirable
gel
strength
(5.1
±
0.5
g),
spreadability
(33.6
1.9
g·s),
pseudoplasticity,
elasticity.
In
vitro
studies
revealed
biphasic
profile,
with
over
72
h
70%
cumulative
release.
significantly
improved
capacity,
protecting
human
fibroblasts
enhancing
cell
viability.
Stability
indicated
that
4
°C
was
optimal
storage
three
months.
Notably,
enhanced
3.7-fold.
Conclusions:
SLN-enriched
effectively
improves
delivery
efficacy,
providing
promising
platform
other
bioactive
compounds
similar
challenges.
Язык: Английский