PFAS Exposure and Kidney Health with Gut Microbiota, Blood Metabolites, and Multi-Organ Implications Across Medical Specialties

European journal of ecology, biology and agriculture., Год журнала: 2025, Номер 2(2), С. 30 - 46

Опубликована: Март 1, 2025

PFAS (per- and polyfluoroalkyl substances) exposure has been linked to kidney damage through mechanisms involving gut microbiota dysbiosis alterations in blood metabolites. These disruptions trigger renal inflammation, oxidative stress, metabolic dysregulation, impairing function. significantly alters microbial communities, impacting metabolites like short-chain fatty acids (SCFAs), bile acids, trimethylamine N-oxide (TMAO). imbalances contribute chronic inflammation fibrosis the gut-kidney axis. Additionally, disrupts related energy metabolism, mitochondrial function, lipid oxidation, amino acid metabolism. Biomarkers such as uric acid, creatinine, homocysteine indicate nephrotoxic stress. This paper explores potential by which impact health interactions with It also highlights its effects role affecting multiple body systems that may involve various medical specialists, internists, gastroenterologists, cardiologists, obstetricians, gynecologists, psychiatrists.

Язык: Английский

Efficacy of Duloxetine in the Management of Diabetic Neuropathy: A Prospective Observational Cohort Study

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Язык: Английский