BioMed Research International,
Год журнала:
2022,
Номер
2022, С. 1 - 10
Опубликована: Окт. 21, 2022
Edible
coatings
have
several
advantages
in
preserving
foods,
such
as
avoiding
water
loss,
controlling
microbial
growth,
and
reducing
the
need
for
preservatives
added
directly
to
product.
Antimicrobial
action
can
be
obtained
by
adding
antimicrobial
substances
including
phenolic
compounds
commonly
found
plant
extracts.
This
study
evaluated
content,
antioxidant
activity
of
pulp,
seed
extracts
Mimusopsis
comersonii
(popularly
known
Brazil
abrico),
besides
were
identified
quantified
pulp
extract.
incorporated
with
extract
order
evaluate
preservation
minimally
processed
apples
baroa
potatoes
against
foodborne
bacteria,
enzymatic
browning
was
also
determined.
Myricetin-3-glucoside,
quercetin-3-glucoside,
kaempferol-3-glucoside
major
flavonoids
apricot
The
inhibited
all
tested
microorganisms,
especially
Staphylococcus
aureus
Salmonella
Typhimurium.
9%
showed
vitro
activity,
addition
being
effective
preventing
up
15
days
storage.
They
2
log
CFU/g
aerobic
mesophiles
after
storage
apples,
even
though
no
inhibition
observed
under
same
conditions.
edible
proved
an
alternative
antibrowning
potatoes.
Chemical Engineering Journal,
Год журнала:
2024,
Номер
494, С. 153064 - 153064
Опубликована: Июнь 12, 2024
Chronic
wounds
are
persistent
non-healing
lesions
whose
complex
management
is
due
to
the
interplay
of
multiple
factors
promoting
chronicity,
such
as
oxidative
stress,
overexpressed
enzyme
activities
impeding
tissue
repair
and
bacterial
contamination.
Currently
marketed
chronic
wound
dressings
designed
mainly
absorb
exudate,
at
most
release
antimicrobial
agents,
usually
ionic
silver.
However,
an
effective
requires
addressing
multifactorial
nature
in
a
holistic
approach.
This
study
explores
potential
metal
phenolic
network
(MPN)
nanoparticles
(NPs),
comprised
epigallocatechin
gallate
(EGCG)
cobalt,
active
agents
structural
elements
dressings.
The
MPN
NPs
were
able
generate
reactive
oxygen
species
(ROS),
disturb
membrane,
inhibit
biofilm
both
gram-positive
Staphylococcus
aureus
gram-negative
Pseudomonas
aeruginosa.
Owing
high
interfacial
activity
their
shells,
drove
self-assembly
thiolated
hyaluronic
acid
(THA)
hydrogels
featuring
injectability,
self-healing,
stimuli-responsive
delivery
microenvironment,
control
over
deleterious
activities,
stress
colonisation.
Specifically,
inhibited
matrix
metalloproteinases
(MMPs)
myeloperoxidase
(MPO)
by
60
80
%,
respectively,
achieved
4-log
reduction
S.
2-log
P.
aeruginosa
concentrations.
Finally,
in-vivo
validated
mouse
animal
model,
showing
lack
toxicity
similar
healing
efficiency
antibiotic-containing
commercial
product.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(3), С. 1816 - 1816
Опубликована: Фев. 5, 2022
The
presence
of
Staphylococcus
epidermidis
biofilms
on
medical
devices
is
a
major
cause
nosocomial
diseases
and
infections.
Extensive
research
directed
at
inhibiting
the
formation
maturation
such
biofilms.
Natural
plant-derived
phenolic
compounds
have
promising
antimicrobial
effects
against
drug-resistant
bacteria.
anti-biofilm
activity
two
selected
(vanillin
syringic
acid)
was
tested
three
biofilm-forming
methicillin-resistant
S.
strains
with
different
genotypes.
Resazurin
assay
combining
crystal
violet
staining
confocal
microscopy
used
for
biofilm
extracellular
polymer
substance
(EPS)
inhibition
tests.
Effects
EPS
as
proteins,
DNA,
polysaccharides
were
also
examined.
Combined
quantitative
real-time
PCR
agr
quorum-sensing
systems
genetic
determinants,
our
complex
analysis
vanillin
acid
showed
similar
strains,
reducing
up
to
80%
55%,
depending
genotype
strain.
agents
are
thus
potentially
useful
inhibitors
Molecules,
Год журнала:
2023,
Номер
28(4), С. 1751 - 1751
Опубликована: Фев. 12, 2023
Biofilms,
which
consist
of
microorganisms
embedded
in
a
polymer-rich
matrix,
contribute
to
variety
infections
and
increase
antimicrobial
resistance.
Thus,
there
is
constant
need
develop
new
chemotherapeutic
agents
combat
biofilms.
This
review
article
focuses
on
the
use
alkyl
gallates,
gallic
acid
its
esters
(methyl,
ethyl,
propyl,
butyl,
hexyl,
octyl,
dodecyl
gallate),
most
are
found
plants,
inhibit
biofilm
formation.
The
studies
under
reveal
that
gallates
have
capacity
prevent
development
eradicate
mature
biofilms
through
mechanisms
suppress
synthesis
extracellular
polymeric
quorum-sensing
signaling,
alter
microbial
cell
membrane.
effects
stronger
greater
length
chain.
Moreover,
gallates’
preventive
activity
against
formation
occurs
at
doses
below
minimum
inhibitory
concentration.
More
importantly,
combining
with
antimicrobials
or
blue-light
irradiation
produces
synergistic
effect
inhibition
can
be
used
treat
overcome
Heliyon,
Год журнала:
2023,
Номер
9(3), С. e14152 - e14152
Опубликована: Фев. 28, 2023
The
expression
of
many
virulence
genes
in
bacteria
is
regulated
by
quorum
sensing
(QS),
and
the
inhibition
this
mechanism
has
been
intensely
investigated.
N-acetylcysteine
(NAC)
good
antibacterial
activity
able
to
interfere
with
biofilm-related
respiratory
infections,
but
little
known
whether
compound
an
effect
on
bacterial
QS
communication.
This
work
aimed
evaluate
potential
NAC
as
a
inhibitor
(QSI)
Pseudomonas
aeruginosa
PAO1
through
silico
vitro
analyses,
well
combination
antibiotic
tobramycin.
Initially,
molecular
docking
analysis
was
performed
between
regulatory
proteins,
LasR
RhlR,
P.
NAC,
3-oxo-C12-HSL,
C4-HSL,
furanone
C30.
sub-inhibitory
concentration
determined
growth
curves.
Then,
we
tests
using
reporter
strains
lasB-gfp
rhlA-gfp,
QS-related
phenotypes.
Finally,
synergistic
tobramycin
calculated
fractional
inhibitory
concentrations
index
(FICi)
investigated
against
growth,
pigment
production,
biofilm
formation.
In
study,
bound
RhlR
proteins
similar
manner
AHL
cognate,
suggesting
that
it
may
be
bind
receptor
vivo.
biosensor
assay,
GFP
signal
turned
down
presence
at
1000,
500,
250,
125
μM
for
rhlA-gfp
(p
<
0.05),
effect.
Pyocyanin
rhamnolipids
decreased
0.05)
up
34
37%,
respectively,
μM.
Swarming
swimming
motilities
were
inhibited
250
10000
Additionally,
2500
reduced
NAC-tobramycin
showed
FICi
0.8,
best
2500–1.07
μM,
inhibiting
formation
60%,
besides
reducing
pyocyanin
pyoverdine
production.
Confocal
microscopy
images
revealed
stronger,
dense,
compact
control,
while
treated
became
thinner
more
dispersed.
Overall,
low
promising
anti-QS
properties
PAO1,
adding
its
already
antibiofilm
agent.
Abstract
Sepsis
is
a
life‐threatening
condition
that
can
progress
to
septic
shock
as
the
body's
extreme
response
pathogenesis
damages
its
own
vital
organs.
Staphylococcus
aureus
(
S.
)
accounts
for
50%
of
nosocomial
infections,
which
are
clinically
treated
with
antibiotics.
However,
methicillin‐resistant
strains
(MRSA)
have
emerged
and
withstand
harsh
antibiotic
treatment.
To
address
this
problem,
curcumin
(CCM)
employed
prepare
carbonized
polymer
dots
(CPDs)
through
mild
pyrolysis.
Contrary
curcumin,
as‐formed
CCM‐CPDs
highly
biocompatible
soluble
in
aqueous
solution.
Most
importantly,
induce
release
neutrophil
extracellular
traps
(NETs)
from
neutrophils,
entrap
eliminate
microbes.
In
an
MRSA‐induced
mouse
model,
it
observed
efficiently
suppress
bacterial
colonization.
Moreover,
intrinsic
antioxidative,
anti‐inflammatory,
anticoagulation
activities
resulting
preserved
functional
groups
precursor
molecule
on
prevent
progression
severe
sepsis.
As
result,
infected
mice
show
significant
decrease
mortality
even
oral
administration.
Histological
staining
indicates
negligible
organ
damage
MRSA‐infected
CCM‐CPDs.
It
believed
vivo
studies
presented
herein
demonstrate
multifunctional
therapeutic
CPDs
hold
great
potential
against
infectious
diseases.
Medicine International,
Год журнала:
2024,
Номер
4(6)
Опубликована: Авг. 30, 2024
As
a
notorious
bacterial
pathogen,
Staphylococcus
aureus
(S.
aureus)
can
readily
induce
infections
in
the
community
and
hospital,
causing
significant
morbidity
mortality.
With
extensive
rise
of
multiple
resistance,
conventional
antibiotic
therapy
has
rapidly
become
ineffective
for
related
infections.
Resveratrol
is
naturally
occurring
polyphenolic
substance
that
been
demonstrated
to
have
effective
antimicrobial
activity
against
S.
aureus.
at
sub‑inhibitory
doses
suppress
expression
virulence
factors,
contributing
attenuated
biofilm
formation,
interference
with
quorum
sensing
inhibition
production
toxins.
promising
efflux
pump
inhibitor,
resveratrol
enhances
susceptibility
certain
extent.
In
conjunction
antibiotics,
displays
unique
synergistic
effects
norfloxacin
aminoglycoside
on
S.
aureus,
yet
antagonizes
lethal
daptomycin,
oxacillin,
moxifloxacin
levofloxacin.
Nevertheless,
given
low
oral
bioavailability
resveratrol,
advanced
formulations
need
be
developed
delay
rapid
metabolism
conversion
or
inactive
conjugates.
The
present
review
discusses
antibacterial
properties
aureus,
an
aim
provide
in‑depth
insight
researchers
address
challenges
resistance.
Critical Reviews in Microbiology,
Год журнала:
2024,
Номер
unknown, С. 1 - 24
Опубликована: Сен. 20, 2024
Procyanidins
(PCs)
have
emerged
as
agents
with
potential
antimicrobial
and
antibiofilm
activities,
although
their
mechanisms
of
action
structure-activity
relationships
remain
poorly
understood.
This
review
assessed
the
applications
these
compounds
to
explore
aspects.
Studies
on
properties
PCs
suggest
that
they
are
involved
in
osmotic
imbalance,
DNA
interactions
metabolic
disruption.
Although
less
studied,
activities
include
antiadhesive
effects
modulation
mobility
quorum
sensing.
However,
most
research
has
used
uncharacterized
plant
extracts
for
