Clinical Oral Investigations, Год журнала: 2024, Номер 28(10)
Опубликована: Сен. 16, 2024
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Май 13, 2023
Abstract In the past period, due to rapid development of next-generation sequencing technology, accumulating evidence has clarified complex role human microbiota in cancer and therapeutic response. More importantly, available seems indicate that modulating composition gut improve efficacy anti-cancer drugs may be feasible. However, intricate complexities exist, a deep comprehensive understanding how interacts with is critical realize its full potential treatment. The purpose this review summarize initial clues on molecular mechanisms regarding mutual effects between development, highlight relationship microbes immunotherapy, chemotherapy, radiation therapy surgery, which provide insights into formulation individualized strategies for management. addition, current emerging microbial interventions as well their clinical applications are summarized. Although many challenges remain now, great importance cannot overstated strategies, it necessary explore holistic approach incorporates modulation cancer.
Язык: Английский
Процитировано
159
ACS Nano, Год журнала: 2024, Номер 18(36), С. 24968 - 24983
Опубликована: Авг. 28, 2024
The dental implant market has experienced explosive growth, owing to the widespread acceptance of implants as core oral rehabilitation. Clinically, achieving simultaneous anti-infective effects and rapid osseointegration is a crucial but challenging task for implants. demand with long-term broad-spectrum antibacterial immune-osteogenic properties growing. Existing methods are limited by lack safety, efficiency, short-lasting ability, inadequate consideration immunomodulatory on osteogenesis. Herein, ZnO/black TiO
Язык: Английский
Процитировано
8
Dentistry Journal, Год журнала: 2025, Номер 13(3), С. 100 - 100
Опубликована: Фев. 26, 2025
Periodontitis and diabetes mellitus are two highly prevalent chronic conditions that share a bidirectional relationship, significantly impacting public health. Periodontitis, gum inflammation caused by microbial dysbiosis, aggravates glycemic control in diabetics, while uncontrolled heightens periodontitis severity. These create vicious cycle, where dysbiosis mutually drive disease progression, exacerbating systemic The underlying mechanisms involve inflammation, immune dysfunction, with both diseases contributing to chain of exacerbates This relationship is significant because managing one condition can impact the other. In diabetic individuals, interventions such as periodontal therapy have shown effectiveness improving control, underscoring potential integrated strategies for these simultaneously. this review, we highlight importance deeper understanding molecular immunological interactions between essential developing therapeutic approaches, enhance quality life patient significantly.
Язык: Английский
Процитировано
1
Frontiers in Endocrinology, Год журнала: 2023, Номер 14
Опубликована: Янв. 23, 2023
Polycystic ovary syndrome (PCOS) and periodontal disease (PDD) share common risk factors. The bidirectional interaction between PCOS PDD has been reported, but until now, the underlying molecular mechanisms remain unclear. Endocrine disorders including hyperandrogenism (HA) insulin resistance (IR) in disturb oral microbial composition increase abundance of pathogens. Additionally, a detrimental effect on supportive tissues, gingiva, ligament, alveolar bone. Systemic low-grade inflammation status, especially obesity, persistent immune imbalance, oxidative stress induced by exacerbate progression PDD. Simultaneously, might through disturbing gut microbiota inducing stress. In addition, genetic or epigenetic predisposition lower socioeconomic status are factors for both diseases. this review, we will present latest evidence association from epidemiological, mechanistic, interventional studies. A deep understanding their be beneficial to provide novel strategies treatment
Язык: Английский
Процитировано
13
Regenerative Biomaterials, Год журнала: 2024, Номер 11
Опубликована: Янв. 1, 2024
Eradicating biofouling from implant surfaces is essential in treating peri-implant infections, as it directly addresses the microbial source for infection and inflammation around dental implants. This controlled laboratory study examines effectiveness of four commercially available debridement solutions '(EDTA (Prefgel®), NaOCl (Perisolv®), H2O2 (Sigma-Aldrich) Chlorhexidine (GUM® Paroex®))' removing acquired pellicle, preventing pellicle re-formation a multi-species oral biofilm growing on titanium surface, compare results with effect novel formulation peroxide-activated 'Poloxamer gel (Nubone® Clean)'. Evaluation removal was conducted using scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy photoelectron to assess surface morphology, elemental composition chemical composition. Hydrophilicity assessed through contact angle measurements. The model included Streptococcus oralis, Fusobacterium nucleatum Aggregatibacter actinomycetemcomitans, reflecting natural microbiome's complexity. Biofilm biomass quantified safranin staining, viability evaluated confocal laser microscopy, SEM used morphological analyses biofilm. Results indicated that while no single agent completely eradicated biofilm, gel' activated 'H2O2' exhibited promising results. It minimized re-contamination by significantly lowering angle, indicating enhanced hydrophilicity. combination also showed notable reduction carbon contaminants, suggesting effective organic residues addition effectively reducing viable bacterial counts. In conclusion, + H2O2' emerged decontamination strategy diseases. underlines importance tailoring treatment methods unique challenges diseases necessity combining decontaminating strategies established mechanical cleaning procedures optimal management
Язык: Английский
Процитировано
4
Gut Microbes, Год журнала: 2024, Номер 16(1)
Опубликована: Окт. 12, 2024
The Gram-negative anaerobic species
Язык: Английский
Процитировано
4
Folia Microbiologica, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Research Journal of Pharmacy and Technology, Год журнала: 2025, Номер unknown, С. 885 - 892
Опубликована: Фев. 27, 2025
Background/purpose: According to The Global Burden of Disease Study in 2016, oral health problems, especially periodontal disease, become the 11th most common globally, including dental cavities, and fungal infection. Epigallocatechin-3-gallate (EGCG), composition green tea, has excellent benefits plays a vital role health, regulating pathogenic bacteria activity that causes inflammation. Stem cells human exfoliated deciduous teeth (SHED) metabolites also have great play an essential sector, as alternative regenerative therapy with its many bioactive activities. This study aims prove antimicrobial power SHED metabolite combined EGCG against Fusobacterium nucleatum (F. nucleatum), Lactobacillus acidophilus (L. acidophilus), Candida albicans (C. albicans). Materials methods: six different passages were prepared Dulbecco’s Modified Eagle medium added EGCG. After 48 hours incubation, Mueller-Hinton agar diffusion method measured inhibition zone. research data was analyzed statistically. Results: antibacterially active L. F. bacteria, but there no antifungal fungus C. albicans. Conclusion: had antibacterial properties did not fungi.
Язык: Английский
Процитировано
0
Frontiers in Microbiology, Год журнала: 2023, Номер 14
Опубликована: Авг. 7, 2023
The broad-spectrum antimicrobial activity of Elsholtzia ciliate essential oil (ECO) has been previously reported, but its effectiveness against halitosis-causing bacteria such as Fusobacterium nucleatum and Porphyromonas gingivalis is not well understood. In this study, we investigated the bacteriostatic ECO planktonic cells biofilms F. P. gingivalis, ability to inhibit bacterial metabolism production volatile sulfur compounds (VSCs) at sub-lethal concentrations. Our findings revealed that exhibited comparable activities chlorhexidine these oral bacteria. Treatment with significantly reduced VSCs, including hydrogen sulfide, dimethyl disulfide, methanethiol, which are major contributors bad breath. As chemical components ECO, carvacrol, p-cymene, phellandrene, were demonstrated in vitro inhibitory effects on their combined use showed synergistic additive effects, suggesting overall derived from cumulative or effect multiple active components. was found have a destructive cell membrane by examining morphology permeability. Furthermore, application induced significant changes composition saliva-derived biofilm, resulting elimination species contribute halitosis, Fusobacterium, Porphyromonas, Prevotella. These results provide experimental evidence for potential clinical applications ECOs prevention treatment halitosis.
Язык: Английский
Процитировано
10