International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 5625 - 5625
Опубликована: Май 22, 2024
We
investigated
the
pharmacokinetic
pathway
of
berberine
and
its
metabolites
in
vitro,
Caco-2
cells,
human
participants
following
administration
dihydroberberine
(DHB)
micellar
(LipoMicel®,
LMB)
formulations.
A
pilot
trial
involving
nine
healthy
volunteers
was
conducted
over
a
24
h
period;
blood
samples
were
collected
subjected
to
Ultra
High-Performance
Liquid
Chromatography–High
Resolution
Mass
Spectrometry
(UHPLC-HRMS)
analyses
quantify
concentrations
metabolites.
Pharmacokinetic
correlations
indicated
that
berberrubine
thalifendine
follow
distinct
metabolic
pathways.
Additionally,
jatrorrhizine
sulfate
appeared
undergo
metabolism
differently
compared
other
sulfated
Moreover,
glucuronide
likely
has
unique
from
glucuronides.
The
revealed
significantly
higher
DHB
treatment
group
LMB
group—except
for
glucuronide,
which
only
detected
group.
Similarly,
results
vitro
investigations
showed
significant
differences
metabolite
profiles
between
LMB.
Dihydroberberine,
dihydroxy-berberrubine/thalifendine
LMB-treated
but
not
DHB-treated
cells;
jatrorrhizine-glucuronide
cells
only.
While
provided
most
metabolites,
both
(Caco-2
cells)
vivo
studies
with
resulted
proportion
unmetabolized
DHB.
These
findings
suggest
potential
clinical
implications
merit
further
investigation
future
large-scale
trials.
Heliyon,
Год журнала:
2024,
Номер
10(17), С. e37283 - e37283
Опубликована: Сен. 1, 2024
There
is
a
growing
concern
among
food
safety
regulators,
the
industry,
and
consumers
about
foodborne
illnesses.
To
improve
increase
shelf
life,
it
necessary
to
use
natural
preservatives.
Natural
antimicrobials
are
safer
than
artificial
preservatives
because
they
can
prevent
microbial
resistance
while
also
meeting
consumers'
demands
for
healthier
food.
This
study
used
Berberine
enhance
antibacterial
activity
of
RSC Advances,
Год журнала:
2024,
Номер
14(9), С. 6096 - 6111
Опубликована: Янв. 1, 2024
Christella
dentata
(Forssk.)
Brownsey
&
Jermy
has
been
commonly
used
in
traditional
medicinal
practices
but
its
effects
on
multi-drug-resistant
(MDR)
bacteria
have
remained
unexplored.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 5625 - 5625
Опубликована: Май 22, 2024
We
investigated
the
pharmacokinetic
pathway
of
berberine
and
its
metabolites
in
vitro,
Caco-2
cells,
human
participants
following
administration
dihydroberberine
(DHB)
micellar
(LipoMicel®,
LMB)
formulations.
A
pilot
trial
involving
nine
healthy
volunteers
was
conducted
over
a
24
h
period;
blood
samples
were
collected
subjected
to
Ultra
High-Performance
Liquid
Chromatography–High
Resolution
Mass
Spectrometry
(UHPLC-HRMS)
analyses
quantify
concentrations
metabolites.
Pharmacokinetic
correlations
indicated
that
berberrubine
thalifendine
follow
distinct
metabolic
pathways.
Additionally,
jatrorrhizine
sulfate
appeared
undergo
metabolism
differently
compared
other
sulfated
Moreover,
glucuronide
likely
has
unique
from
glucuronides.
The
revealed
significantly
higher
DHB
treatment
group
LMB
group—except
for
glucuronide,
which
only
detected
group.
Similarly,
results
vitro
investigations
showed
significant
differences
metabolite
profiles
between
LMB.
Dihydroberberine,
dihydroxy-berberrubine/thalifendine
LMB-treated
but
not
DHB-treated
cells;
jatrorrhizine-glucuronide
cells
only.
While
provided
most
metabolites,
both
(Caco-2
cells)
vivo
studies
with
resulted
proportion
unmetabolized
DHB.
These
findings
suggest
potential
clinical
implications
merit
further
investigation
future
large-scale
trials.
