Annals of the New York Academy of Sciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 5, 2025
Abstract
The
human
gut
microbiome
is
a
complex
ecosystem
that
plays
vital
role
in
maintaining
health
and
contributing
to
the
pathogenesis
of
various
diseases.
This
review
proposes
transformative
approach
involves
engineering
artificial
microbial
consortia—precisely
designed
communities
microorganisms—for
personalized
modulation
targeted
therapeutic
interventions.
By
integrating
synthetic
biology,
systems
advanced
culturing
techniques,
tailored
consortia
can
be
developed
perform
specific
functions
within
gut,
including
production
molecules,
immune
responses,
competition
against
pathogenic
bacteria.
In
vitro
vivo
studies
indicate
these
engineered
effectively
restore
balance
enhance
host
resilience.
holds
immense
potential
revolutionize
healthcare
by
addressing
root
causes
diseases
such
as
metabolic
disorders,
inflammatory
conditions,
gastrointestinal
infections
through
precise
manipulation
microbiome.
Future
research
should
focus
on
rigorous
clinical
trials
evaluate
safety,
efficacy,
long‐term
impacts
diverse
populations,
paving
way
for
innovative
therapies
promote
overall
well‐being.
Minerals,
Год журнала:
2023,
Номер
13(6), С. 828 - 828
Опубликована: Июнь 18, 2023
The
rapid
and
improper
disposal
of
electronic
waste
(e-waste)
has
become
an
issue
great
concern,
resulting
in
serious
threats
to
the
environment
public
health.
In
addition,
e-waste
is
heterogenous
nature,
consisting
a
variety
valuable
metals
large
quantities,
hence
need
for
development
promising
technology
ameliorate
environmental
hazards
associated
with
indiscriminate
dumping
e-waste,
recovery
metal
components
present
materials,
thus
promoting
management
reuse.
Various
physico-chemical
techniques
including
hydrometallurgy
pyrometallurgy
have
been
employed
past
mobilization
from
e-waste.
However,
these
approaches
proven
be
inept
due
high
operational
costs
linked
consumption
huge
amounts
chemicals
energy,
together
loss
release
secondary
byproducts.
An
alternative
method
avert
above-mentioned
limitations
adoption
microorganisms
(bioleaching)
as
efficient,
cost-effective,
eco-friendly,
sustainable
solubilization
Metal
influenced
by
microbiological,
physico-chemical,
mineralogical
parameters.
This
review,
therefore,
provides
insights
into
strategies
or
pathways
used
International Journal of Clinical Practice,
Год журнала:
2024,
Номер
2024, С. 1 - 38
Опубликована: Март 9, 2024
The
emergence
of
antibiotic-resistant
strains,
the
decreased
effectiveness
conventional
therapies,
and
side
effects
have
led
researchers
to
seek
a
safer,
more
cost-effective,
patient-friendly,
effective
method
that
does
not
develop
antibiotic
resistance.
With
progress
in
synthetic
biology
genetic
engineering,
genetically
engineered
microorganisms
treatment,
prophylaxis,
drug
delivery,
diagnosis
been
developed.
present
study
reviews
types
bacteria
phages,
their
impacts
on
diseases,
cancer,
metabolic
inflammatory
disorders,
biosynthesis
these
modified
route
administration,
environment.
We
conclude
can
be
considered
promising
candidates
for
adjunctive
treatment
diseases
cancers.
Plants,
Год журнала:
2025,
Номер
14(2), С. 191 - 191
Опубликована: Янв. 11, 2025
The
rapid
growth
of
the
human
population
has
significantly
increased
demand
for
food,
leading
to
intensification
agricultural
practices
that
negatively
impact
environment.
Climate
change
poses
a
significant
threat
global
food
production,
as
it
can
disrupt
crop
yields
and
modify
lifecycle
stages
phytopathogens
pests.
To
address
these
challenges,
use
microbial
inoculants,
which
are
bioproducts
containing
beneficial
microorganisms
known
plant
promotion
(PGPMs),
emerged
an
innovative
approach
in
sustainable
agriculture.
This
review
covers
isolation
identification
strains,
screening
selection
process,
optimization
production
techniques,
importance
quality
control
field
testing.
It
also
discusses
key
points
development
formulation
high-quality
well
highlights
their
advancements,
current
future
directions
research
application.
Applied Sciences,
Год журнала:
2023,
Номер
13(14), С. 8439 - 8439
Опубликована: Июль 21, 2023
There
are
several
industrial
processes
in
which
heavy
metals
used,
including
but
not
limited
to
chrome
plating
and
tanning.
Amongst
the
most
toxic
human
health
arsenic,
cadmium,
chromium,
lead,
copper,
nickel,
mercury.
The
aforementioned
possess
ability
cause
contamination
upon
their
release
into
environment.
Humans
aquatic
terrestrial
animals
at
risk
from
water
soil.
Heavy
metal
toxicity
has
potential
result
complications,
such
as
renal
hepatic
impairment,
dermatological
afflictions,
cognitive
lethargy,
potentially
oncogenic
manifestations.
removal
of
wastewater
soil
can
be
accomplished
using
a
variety
conventional
methods,
membrane
filtration,
reverse
osmosis,
chemical
reduction,
adsorption.
These
methods
have
disadvantages,
generating
an
abundance
secondary
pollutants,
entail
significantly
higher
costs
comparison
biological
methods.
Conversely,
eco-friendly
techniques
based
on
microbes
numerous
advantages.
This
review
provides
comprehensive
overview
that
remove
ions,
both
metabolically
dependent
independent.
Additionally,
we
also
focused
source
these
metals.
study
is
expected
particularly
beneficial
for
development
treatment
systems
water.
Korean Circulation Journal,
Год журнала:
2023,
Номер
53(8), С. 499 - 499
Опубликована: Янв. 1, 2023
Cardiovascular
diseases
(CVDs),
including
coronary
artery
disease,
stroke,
heart
failure,
and
hypertension,
are
the
global
leading
causes
of
death,
accounting
for
more
than
30%
deaths
worldwide.
Although
risk
factors
CVDs
have
been
well
understood
various
treatment
preventive
measures
established,
mortality
rate
financial
burden
expected
to
grow
exponentially
over
time
due
changes
in
lifestyles
increasing
life
expectancies
present
generation.
Recent
advancements
metagenomics
metabolomics
analysis
identified
gut
microbiome
its
associated
metabolites
as
potential
CVDs,
suggesting
possibility
developing
effective
novel
therapeutic
strategies
against
CVD.
In
addition,
evidence
has
demonstrated
alterations
ratio
Firmicutes
Bacteroidetes
imbalance
microbial-dependent
metabolites,
short-chain
fatty
acids
trimethylamine
N-oxide,
play
a
crucial
role
pathogenesis
However,
exact
mechanism
action
remains
undefined
this
day.
review,
we
focus
on
compositional
related
CVDs.
Moreover,
targeting
discussed.
Microorganisms,
Год журнала:
2024,
Номер
12(2), С. 238 - 238
Опубликована: Янв. 23, 2024
Gut
luminal
dysbiosis
and
pathobiosis
result
in
compositional
biodiversified
alterations
the
microbial
host
co-metabolites.
The
primary
mechanism
of
bacterial
evolution
is
horizontal
gene
transfer
(HGT),
acquisition
new
traits
can
be
achieved
through
exchange
mobile
genetic
elements
(MGEs).
Introducing
genetically
engineered
microbes
(GEMs)
might
break
harmonized
balance
intestinal
compartment.
present
objectives
are:
1.
To
reveal
role
played
by
GEMs’
transfers
changing
landscape
enteric
microbiome
eubiosis
2.
expand
on
potential
detrimental
effects
those
changes
human
genome
health.
A
search
articles
published
PubMed/MEDLINE,
EMBASE,
Scielo
from
2000
to
August
2023
using
appropriate
MeSH
entry
terms
was
performed.
exchanges
induce
multiple
diseases.
GEMs
change
long-term
natural
pro-
or
eukaryotic
cell
inhabitants.
worldwide
regulatory
authority’s
safety
control
not
enough
protect
public
Viability,
biocontainment,
many
other
aspects
are
only
partially
controlled
harmful
consequences
for
health
should
avoided.
It
important
remember
that
prevention
most
cost-effective
strategy
primum
non
nocere
focus.
Green Chemistry Letters and Reviews,
Год журнала:
2024,
Номер
17(1)
Опубликована: Май 31, 2024
Several
industries
such
as
leather
tanning,
coal
mining,
steel
and
metal
processing
are
responsible
for
heavy
metals
contamination
in
water.
Heavy
water
can
have
harmful
effects
on
both
aquatic
terrestrial
animals
by
entering
the
food
chain.
Due
to
higher
toxicity
of
metals,
it
is
necessary
remove
ions
from
There
several
physio-chemical
methods
available,
including
ion
exchange,
membrane
filtration,
chemical
oxidation,
electrochemical
methods.
However,
these
some
disadvantages
like
expensive
generating
byproducts.
Biosorption
a
cost-effective
eco-friendly
method
removal
contaminated
Biosorbents
derived
biomasses
plant,
bacterial,
algal,
fungal,
agro-waste,
etc.
The
biosorbents
functional
groups
their
surface
providing
them
high
binding
capacity
ions.
Mathematical
models
isotherms,
thermodynamics,
kinetic
studies
help
explain
how
adsorb
biosorbents.
This
review
provides
comprehensive
details
source,
biosorption
also
mechanism
mathematical
models.
Microorganisms,
Год журнала:
2025,
Номер
13(3), С. 599 - 599
Опубликована: Март 5, 2025
Microbial
engineering
has
made
a
significant
breakthrough
in
pharmaceutical
biotechnology,
greatly
expanding
the
production
of
biologically
active
compounds,
therapeutic
proteins,
and
novel
drug
candidates.
Recent
advancements
genetic
engineering,
synthetic
biology,
adaptive
evolution
have
contributed
to
optimization
microbial
strains
for
applications,
playing
crucial
role
enhancing
their
productivity
stability.
The
CRISPR-Cas
system
is
widely
utilized
as
precise
genome
modification
tool,
enabling
enhancement
metabolite
biosynthesis
activation
biological
pathways.
Additionally,
biology
approaches
allow
targeted
design
microorganisms
with
improved
metabolic
efficiency
potential,
thereby
accelerating
development
new
products.
integration
artificial
intelligence
(AI)
machine
learning
(ML)
plays
vital
further
advancing
by
predicting
network
interactions,
optimizing
bioprocesses,
discovery
process.
However,
challenges
such
efficient
pathways,
ensuring
sustainable
industrial-scale
production,
meeting
international
regulatory
requirements
remain
critical
barriers
field.
Furthermore,
mitigate
potential
risks,
it
essential
develop
stringent
biocontainment
strategies
implement
appropriate
oversight.
This
review
comprehensively
examines
recent
innovations
analyzing
key
technological
advancements,
challenges,
future
perspectives.
The
inherent
complexity
of
biological
systems
is
a
major
barrier
to
our
understanding
cellular
physiology.
Bacteria
with
markedly
fewer
genes
than
their
close
relatives,
or
reduced
genome
bacteria,
are
promising
models
less
complexity.
Reduced
bacteria
can
also
have
superior
properties
for
industrial
use,
provided
the
reduction
does
not
overly
restrict
strain
robustness.
Naturally
such
as
alphaproteobacterium
