Thrombosis Journal,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 29, 2024
The
gut
microbiota
of
venous
thromboembolism
(VTE)
patients
exhibited
significant
alterations.
However,
the
causal
relationship
between
and
VTE
has
not
been
fully
understood.
This
study
aimed
to
assess
risk
using
a
two-sample
Mendelian
Randomization
(MR)
study.
genetic
data
were
collected
from
MiBioGen
consortium
UK
biobank,
respectively.
potential
was
investigated
MR
analysis,
including
inverse
variance
weighted
(IVW),
median,
MR-Egger,
simple
mode,
mode
methods.
Cochran's
Q-test,
MR-PRESSO,
MR-Egger
regression
intercept
analysis
utilized
perform
sensitivity
analysis.
At
genus
level,
results
found
that
Coprococcus1
(OR:
1.0029,
95%
CI:
1.0005–1.0054,
p
=
0.0202)
suggestively
linked
with
an
increased
VTE,
while
Slackia
(odds
ratio
(OR):
0.9977,
confidence
interval
(CI):
0.9957–0.9998,
0.0298),
Butyricicoccus
0.9971,
0.9945–0.9997,
0.0309),
Eubacterium
coprostanoligenes
group
0.9972,
0.9946–0.9999,
0.0445),
Bacteroides
0.9964,
0.9932–0.9995,
0.0234)
associated
reduced
VTE.
No
heterogeneity
horizontal
pleiotropy
detected.
there
relationships
five
Our
findings
may
provide
new
insights
into
mechanisms
American Journal of Cancer Research,
Год журнала:
2024,
Номер
14(4), С. 1577 - 1593
Опубликована: Янв. 1, 2024
Follicular
lymphoma
(FL),
derived
from
germinal
centre
(GC)
B
cells,
is
a
kind
of
systemic
neoplasm.
Even
though
FL
indolent,
it
remains
an
incurable
haematology
Neoplasm.
Accumulating
evidence
has
suggested
that
the
circulating
cytokine
associated
with
development
FL,
yet
causal
relationship
between
and
cytokines
undetermined.
Therefore,
we
conducted
two-sample
Mendelian
randomization
(MR)
to
confirm
link
levels
use
summary
data
on
FL.
All
these
genome-wide
association
study
were
Genome-wide
pQTL
mapping
which
contains
14,824
individuals.
acquired
exclusively
FinnGen,
where
218,792
individuals
(522
cases
vs.
218,270
controls)
involved.
Various
statistical
methods,
including
inverse
variance
weighted
method
(IVW),
median
(WME),
simple
model,
model
(WM)
MR-Egger,
used
evaluate
potential
connection
Sensitivity
analysis,
involves
examination
heterogeneity,
pleiotropy,
leave-one-out
method,
was
also
performed
ensure
more
trustworthy
results.
A
bidirectional
MR
test
direction
Combining
all
steps
revealed
four
cytokines:
C-X-C
motif
chemokine
ligand
5
(CXCL5),
interleukin-15
receptor
(IL15RA),
interleukin-20
(IL20),
neurotrophin-3
(NT-3).
The
risk
may
be
inversely
linked
CXCL5
(OR=0.73,
CI:
0.545-0.979,
P=0.036),
IL-15RA
(OR=0.669,
0.451-0.993,
P=0.046),
IL-20
(OR=0.565,
0.325-0.981,
P=0.043)
but
positively
NT-3
(OR=1.872,
1.063-3.297,
P=0.03).
In
addition,
in
our
study,
no
effect
demonstrated
significant
heterogeneity
pleiotropy
found.
Our
research
along
both
anti-protective
CXCL5,
IL-15RA,
protective
These
findings
aim
provide
new
clues
regarding
pathogenesis
extend
therapeutic
interventions.
Immunity Inflammation and Disease,
Год журнала:
2024,
Номер
12(7)
Опубликована: Июль 1, 2024
Abstract
Background
Studies
have
indicated
a
close
association
between
dysbiosis
of
the
gut
microbiota
and
chronic
sinusitis.
However,
causal
relationship
risk
sinusitis
remains
unclear.
Methods
Using
genome‐wide
study
(GWAS)
data
for
sinusitis,
we
conducted
two‐sample
Mendelian
randomization
(MR)
to
determine
potential
We
employed
inverse
variance‐weighted
(IVW)
method
as
primary
analytical
approach
estimate
effect.
Additionally,
sensitivity,
heterogeneity,
pleiotropy
analyses
were
evaluate
robustness
results.
Reverse
MR
analysis
was
also
applied
investigate
reverse
causality.
Results
Through
analysis,
identified
17
classifications
that
are
closely
associated
with
after
Bonferroni
multiple
correction,
only
class
Bacilli
(odds
ratio:
0.785,
95%
confidence
interval:
0.677–0.911,
p
=
.001,
false
discovery
rate
0.023)
maintained
significant
negative
Sensitivity
did
not
reveal
any
evidence
heterogeneity
or
horizontal
pleiotropy.
found
five
significantly
but
they
no
longer
correction.
There
suggest
Bacilli.
Conclusion
Specific
predicted
by
genetics
exhibit
may
protective
effect
on
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 18, 2024
Abstract
Background
Perianal
abscesses
are
common
in
colorectal
surgery,
requiring
surgical
drainage
and
wound
care.
Diabetic
patients
often
experience
delayed
healing
increased
infection
risk
due
to
systemic
factors
altered
microbiota.
This
study
investigated
the
postoperative
microbiota
diabetic
with
perianal
using
16s
rRNA
sequencing,
aiming
identify
potential
microbial
contributions
outcomes.
Results
The
compared
between
22
non-diabetic
undergoing
abscess
surgery.
exhibited
significantly
lower
diversity
richness
patients.
Specific
bacterial
taxa
were
enriched
group,
including
Enterobacteriaceae,
Streptococcus,
Lactobacillales,
while
beneficial
bacteria
like
Bacteroides
Ruminococcaceae
reduced.
Functional
prediction
analysis
revealed
significant
differences
metabolic
pathways,
wounds
showing
carbohydrate
metabolism
chitin
biosynthesis,
decreased
energy
endocrine
system
function.
Conclusions
highlights
distinct
characteristics
of
abscesses,
suggesting
healing.
findings
underscore
importance
considering
microbiome
managing
care
for
Strategies
modulate
microbiota,
such
as
probiotics
or
antibiotics,
may
be
improving
Further
research
is
needed
understand
specific
mechanisms
driving
observed
dysbiosis
its
impact
on
Thrombosis Journal,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 29, 2024
The
gut
microbiota
of
venous
thromboembolism
(VTE)
patients
exhibited
significant
alterations.
However,
the
causal
relationship
between
and
VTE
has
not
been
fully
understood.
This
study
aimed
to
assess
risk
using
a
two-sample
Mendelian
Randomization
(MR)
study.
genetic
data
were
collected
from
MiBioGen
consortium
UK
biobank,
respectively.
potential
was
investigated
MR
analysis,
including
inverse
variance
weighted
(IVW),
median,
MR-Egger,
simple
mode,
mode
methods.
Cochran's
Q-test,
MR-PRESSO,
MR-Egger
regression
intercept
analysis
utilized
perform
sensitivity
analysis.
At
genus
level,
results
found
that
Coprococcus1
(OR:
1.0029,
95%
CI:
1.0005–1.0054,
p
=
0.0202)
suggestively
linked
with
an
increased
VTE,
while
Slackia
(odds
ratio
(OR):
0.9977,
confidence
interval
(CI):
0.9957–0.9998,
0.0298),
Butyricicoccus
0.9971,
0.9945–0.9997,
0.0309),
Eubacterium
coprostanoligenes
group
0.9972,
0.9946–0.9999,
0.0445),
Bacteroides
0.9964,
0.9932–0.9995,
0.0234)
associated
reduced
VTE.
No
heterogeneity
horizontal
pleiotropy
detected.
there
relationships
five
Our
findings
may
provide
new
insights
into
mechanisms
