Journal of Oral and Maxillofacial Pathology,
Год журнала:
2024,
Номер
28(4), С. 665 - 671
Опубликована: Окт. 1, 2024
In
recent
years,
Candida
albicans
has
emerged
as
a
significant
opportunistic
pathogen,
causing
various
infections,
particularly
in
immunocompromised
geriatric
individuals.
One
of
the
major
hindrances
managing
infections
lies
its
potential
to
develop
and
survive
biofilms,
which
demonstrate
resistance
conventional
antifungal
therapies,
thereby
complicating
treatment
strategies.
While
clove
oil
shown
promising
results
agent,
specific
anti-biofilm
effects
against
biofilms
remain
relatively
underexplored.
Therefore,
there
is
need
for
comprehensive
review
evaluate
existing
literature
on
properties
mechanisms
action
biofilms.
Such
will
provide
valuable
insights
into
therapeutic
applications
combating
biofilm-associated
infections.
This
enable
us
infer
understand
albicans.
systematic
aims
determine
efficacy
was
registered
'PROSPERO'
(CRD42024524134)
followed
Preferred
Reporting
Items
Systematic
Reviews
Meta-Analyses
guidelines.
The
searches
used
Google
Scholar,
PubMed,
Science
Direct
databases.
All
original
studies
published
English
from
2004
2023
were
included.
From
37
found
online,
only
four
reviewed.
Results
showed
that
had
activity
when
assessed
Our
provides
oil's
agent
Clove
also
represents
avenue
future
research
development
Frontiers in Oral Health,
Год журнала:
2025,
Номер
5
Опубликована: Янв. 15, 2025
The
morbidity
of
oral
disorders,
including
gingivitis,
caries,
endodontic-periodontal
diseases,
and
cancer,
is
relatively
high
globally.
Pathogenic
cells
are
the
root
cause
many
therapies
depend
on
eradicating
them.
Photodynamic
therapy
(PDT)
has
been
established
as
a
potential
non-invasive
local
adjuvant
treatment
for
disorders.
PDT
consists
three
essential
components:
photosensitizer
(PS),
light
source
with
certain
wavelength,
oxygen
dissolved
in
cells.
These
components
can
interact
to
damage
proteins,
lipids,
nucleic
acids,
other
biological
within
diseased
tissues.
Herein,
we
aimed
provide
detailed
understanding
how
it
treat
diseases.
Concerns
about
remedies
also
factor.
shown
numerous
clinical
studies
be
an
efficient
supplementary
that
reduce
pathogenic
great
dental
applications,
treating
bacterial
fungal
infections
during
canal
preventing
potentially
malignant
periodontitis,
peri-implant
Although
promoted
having
significant
utility
dentistry,
more
research
must
conducted
before
being
used
broadly.
Microscopy Research and Technique,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 21, 2025
Biofilm
formation
on
tooth
surfaces
is
a
primary
contributor
to
dental
caries
and
periodontal
diseases.
Streptococcus
mutans
recognized
for
its
role
in
biofilm
production,
significantly
influencing
the
development
of
caries.
Key
virulence
factors
associated
with
S.
biofilms
include
acid
tolerance,
synthesis
exopolysaccharides
(EPS).
This
study
presents
novel
approach
by
focusing
loading
biosynthesized
zirconia
nanoparticles
(ZrO2
NPs)
onto
polyethylene
glycol/sodium
alginate
(PEG/SA)
hydrogel
nanocomposite,
evaluating
their
effects
biofilm-forming
ability
both
vivo
vitro.
ZrO2
NPs
were
using
Citrus
aurantifolia
(C.
aurantifolia)
extract
incorporated
into
PEG/SA
beads
through
sol-gel
process.
The
PEG/SA/ZrO2
nanocomposite
was
confirmed
diverse
analyzes,
including
UV-visible
spectroscopy,
particle
size
measurement,
morphology
examination,
spectral
analysis,
thermal
gravimetric
analysis
(TGA)
hemolysis
studies.
average
approximately
26
nm,
while
exhibited
highly
porous,
sheet-like
surface
structure.
In
vitro
results
demonstrated
inhibition
zones
30
28
mm
against
mutans,
respectively,
minimum
inhibitory
concentration
(MIC)
12.5
mg/mL.
growth
curve
indicated
complete
decline
an
87%
reduction
when
treated
beads.
SEM
revealed
that
cells
appeared
lysed
or
crumpled,
losing
characteristic
coccal
shape
after
exposure
Additionally,
images
effective
prevention
attachment
teeth
encapsulated
hydrogel,
altering
mature
developed
treatment.
Finally,
incorporation
hydrogels
demonstrates
significant
potential
as
strategy
inhibiting
may
serve
promising
topical
agent
reducing
Further
studies
could
explore
long-term
efficacy
clinical
applications
this
oral
health
care.
Frontiers in Oral Health,
Год журнала:
2024,
Номер
5
Опубликована: Май 30, 2024
Chronic
periodontitis
is
a
ubiquitous
inflammatory
disease
in
dental
healthcare
that
challenging
to
treat
due
its
impact
on
bone
and
tooth
loss.
Conventional
mechanical
debridement
has
been
eliminating
complex
subgingival
biofilms.
Hence,
adjunctive
approaches
like
low-level
laser
antimicrobial
photodynamic
therapy
(A-PDT)
utilising
methylene
blue
(MB)
have
emerging
recent
times.
This
review
evaluates
the
latest
research
use
of
MB-mediated
A-PDT
decrease
microbial
count
enhance
clinical
results
chronic
periodontitis.
Studies
shown
interaction
between
light
MB
generates
phototoxic
effect
thereby,
pathogenic
bacteria
within
periodontal
pockets.
Moreover,
numerous
trials
using
can
reduce
probing
depths,
improve
attachment
levels,
bleeding
during
comparison
traditional
treatment
approaches.
Notably,
shows
superior
antibiotic
resistance
compared
conventional
treatments.
In
conclusion,
promise
as
an
for
Additional
required
standardize
protocols
assess
long-term
outcomes
with
Pharmaceutics,
Год журнала:
2024,
Номер
16(6), С. 759 - 759
Опубликована: Июнь 4, 2024
Endodontic
infections
arise
from
the
interactive
activities
of
microbial
communities
colonizing
in
intricate
root
canal
system.
The
present
study
aims
to
update
latest
knowledge
nanomaterials,
their
antimicrobial
mechanisms,
and
applications
endodontics.
A
detailed
literature
review
current
nanomaterials
used
endodontic
was
performed
using
PubMed
database.
Antimicrobial
with
a
small
size,
large
specific
surface
area,
high
chemical
activity
are
introduced
act
as
irrigants,
photosensitizer
delivery
systems,
medicaments,
or
modify
sealers.
application
field
could
enhance
efficiency,
increase
dentin
tubule
penetration,
improve
treatment
outcomes.
This
supports
potential
promising
strategy
treating
infections.
Photodiagnosis and Photodynamic Therapy,
Год журнала:
2025,
Номер
unknown, С. 104547 - 104547
Опубликована: Март 1, 2025
The
inherent
surface
porosities
of
ceramic
brackets
can
enhance
bacterial
plaque
accumulation.
This
study
assessed
the
in-vitro
effect
photodynamic
therapy
(PDT)
with
two
photosensitizers
(PSs)
on
Streptococcus
mutans
(S.
mutans)
load
around
metal
and
bonded
to
enamel.
In
this
in
vitro
experimental
study,
48
sound
premolars
extracted
for
orthodontic
reasons
were
randomly
assigned
groups
(n=24)
bonding
brackets.
After
bracket
bonding,
tooth-bracket
assemblies
inoculated
S.
mutans,
each
group
was
divided
into
three
subgroups
(n=8)
control,
PDT
toluidine
blue
O
(TBO)
635
nm
laser,
indocyanine
green
(ICG)
808
laser.
colony
count
quantified
subgroup,
analyzed
by
repeated
measures
ANOVA.
Ceramic
showed
a
significantly
higher
than
control
subgroup
7.057
log10
CFUs/mL
(P<0.05).
PDT,
irrespective
PS
type,
decreased
both
(by
7.616
ICG
7.594
TBO
subgroup)
7.512
7.505
difference
not
significant
between
after
(P=0.541
P=0.101
TBO).
Within
limitations
as
an
attempt
predict
what
might
happen
vivo,
results
that
enamel,
type
PS.
Thus,
may
be
considered
possibly
efficient
strategy
minimize
especially
