bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 15, 2023
Abstract
The
ability
to
modify
and
control
natural
engineered
microbiomes
is
essential
for
biotechnology
biomedicine.
Fungi
are
critical
members
of
most
microbiomes,
yet
technology
modifying
the
fungal
a
microbiome
has
lagged
far
behind
that
bacteria.
Interdomain
conjugation
(IDC)
promising
approach,
as
DNA
transfer
from
bacterial
cells
yeast
enables
in
situ
modification.
While
such
genetic
transfers
have
been
known
naturally
occur
wide
range
eukaryotes,
thought
contribute
their
evolution,
IDC
understudied
technique
or
fungal-bacterial
consortia.
One
major
obstacle
widespread
use
its
limited
efficiency.
In
this
work,
we
utilize
interactions
between
genetically
tractable
Escherichia
coli
Saccharomyces
cerevisiae
incidence
IDC.
We
test
landscape
population
donors
recipients
find
commensalism
leads
maximized
IDC,
both
culture
mixed
colonies.
demonstrate
capacity
cell-to-cell
binding
via
mannoproteins
assist
culture,
model
how
these
tunable
controls
can
predictably
yield
outcomes.
Further,
lessons
be
utilized
lastingly
alter
recipient
population,
by
“rescuing”
poor-growing
collapsing
stable
novel
IDC-mediated
CRISPR/Cas9
system.
Journal of Fungi,
Год журнала:
2024,
Номер
10(3), С. 167 - 167
Опубликована: Фев. 21, 2024
Industrial
development
has
enhanced
the
release
into
environment
of
large
quantities
chemical
compounds
with
high
toxicity
and
limited
prospects
degradation.
The
pollution
soil
water
xenobiotic
chemicals
become
a
major
ecological
issue;
therefore,
innovative
treatment
technologies
need
to
be
explored.
Fungal
bioremediation
is
promising
technology
exploiting
their
metabolic
potential
remove
or
lower
concentrations
xenobiotics.
In
particular,
white
rot
fungi
(WRF)
are
unique
microorganisms
that
show
capacities
degrade
wide
range
toxic
such
as
synthetic
dyes,
chlorophenols,
polychlorinated
biphenyls,
organophosphate
pesticides,
explosives
polycyclic
aromatic
hydrocarbons
(PAHs).
this
review,
we
address
main
classes
enzymes
involved
in
fungal
degradation
organic
pollutants,
mechanisms
used
by
these
suitability
biomass
extracellular
for
bioremediation.
We
also
exemplify
role
several
degrading
pollutants
PAHs
emerging
pharmaceuticals
perfluoroalkyl/polyfluoroalkyl
substances
(PFASs).
Finally,
discuss
existing
current
limitations
using
WRF
polluted
environments
future
strategies
improve
biodegradation
processes.
Health Sciences Review,
Год журнала:
2024,
Номер
11, С. 100155 - 100155
Опубликована: Март 11, 2024
Globally,
antimicrobial
(AMR)
or
multi-drug
resistance
(MDR)
constitutes
a
current
health
challenge
that
is
predicted
to
cause
increased
infections
rates
with
adverse
socioeconomic
impacts
through
increase
in
healthcare
costs.
In
addition,
the
group
of
Enterococcus
faecium,
Staphylococcus
aureus,
Klebsiella
pneumoniae,
Acinetobacter
baumannii,
Pseudomonas
aeruginosa
and
Enterobacter
spp.
(ESKAPE)
pathogens
debilitating
(community
nosocomial)
are
classed
as
priority
1
AMR
pathogens.
This
systematic
report
therefore
aimed
at
providing
detailed
coverage
new
targets
for
novel
antimicrobials
development
against
MDR
ESKAPE
mitigate
future
spread
improve
public
indices.
The
prevalent
bacterial
show
high
quinolones,
lactams,
cephalosporins,
carbapenems
other
antibiotic
groups,
ability
form
biofilms
linked
various
quorum
sensing
systems
(QSSs)
boost
their
virulence.
These
QS
pathways
have
become
viable
drug
design
efforts
development.
Also,
since
antibiotics
discovery
has
waned
past
decade,
emergence
advanced
computational
modelling
technologies
design,
repurposing
may
yet
bridge
gap.
As
such,
this
work
we
provided
comprehensive
overview
using
relevant,
included
data
findings
on
pathogens,
QSSs
target
agents'
development,
contributions
tools
heart
advancements
roles
bioprospecting
developing
'druggable'
candidates
therapies
anti-biofilm,
anti-quorum
activities
AMR,
biofilm
QS-related
pathogenicity
factors.
Processes,
Год журнала:
2025,
Номер
13(4), С. 1034 - 1034
Опубликована: Март 31, 2025
The
extensive
use
of
pharmaceuticals
in
human
and
veterinary
medicine
has
led
to
their
persistent
environmental
release,
posing
ecological
public
health
risks.
Major
sources
include
manufacturing
effluents,
excretion,
aquaculture,
improper
disposal,
contributing
bioaccumulation
ecotoxicity.
Mycoremediation
is
the
fungal-mediated
biodegradation
pharmaceuticals,
offers
a
promising
sustainable
approach
mitigate
pharmaceutical
pollution.
Studies
have
reported
that
certain
fungal
species,
including
Trametes
versicolor
Pleurotus
ostreatus,
can
degrade
up
90%
contaminants,
such
as
diclofenac,
carbamazepine,
ibuprofen,
within
days
weeks,
depending
on
conditions.
Fungi
produce
range
extracellular
enzymes,
laccases
peroxidases,
alongside
intracellular
enzymes
like
cytochrome
P450
monooxygenases,
which
catalyze
transformation
complex
compounds.
These
play
an
essential
role
modifying,
detoxifying,
mineralizing
xenobiotics,
thereby
reducing
persistence
toxicity.
effectiveness
biotransformation
influenced
by
factors
substrate
specificity,
enzyme
stability,
Optimal
degradation
typically
occurs
at
pH
4.5–6.0
temperatures
20–30
°C.
Recent
advancements
engineering,
immobilization
techniques,
bioreactor
design
improved
catalytic
efficiency
process
feasibility.
However,
scaling
fungal-based
remediation
systems
for
large-scale
applications
remains
challenge.
Addressing
these
limitations
with
synthetic
biology,
metabolic
other
biotechnological
innovations
could
further
enhance
enzymatic
pharmaceuticals.
This
review
highlights
innovations,
applications,
challenges
mycoremediation,
emphasizing
potential
fungi
transformative
solution
waste
management.
The Canadian Journal of Chemical Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 23, 2025
Abstract
Benzotriazoles
are
a
group
of
persistent
and
mobile
substances
commonly
found
in
aquatic
environments
due
to
inefficient
treatment
conventional
sewage
plants.
Hence,
it
is
crucial
explore
alternative
technologies
for
their
degradation
avoid
adverse
effects
on
the
environment
human
health.
The
potential
removal
capability
four
benzotriazoles
one
benzothiazole
(1H‐benzotriazole,
BTR;
4‐methyl‐1H‐benzotriazole,
4TTR;
5‐methyl‐1H‐benzotriazole,
5TTR;
5‐chlorobenzotriazole,
CBTR;
xylytriazole,
XTR;
2‐Hydroxybenzothiazole,
OH‐BTH)
from
domestic
wastewater
was
investigated
using
white‐rot
fungus
Pleurotus
ostreatus
pellet
form.
study
conducted
bioreactors
operated
repeated
batch
cycles
mode.
results
showed
that
fungal
reactor
achieved
higher
rate
CBTR
(70%
±
17%)
compared
control
(62%
16%).
Furthermore,
other
compounds
(BTR,
5‐TTR,
ranged
17%
19%,
whereas
exhibited
no
these
compounds.
Overall,
findings
indicate
reactors
wastewater.
Journal of Applied and Natural Science,
Год журнала:
2024,
Номер
16(2), С. 741 - 751
Опубликована: Июнь 19, 2024
Ever
since
the
start
of
Industrial
Revolution,
environmental
pollution
has
significantly
increased.
The
prominent
cause
most
diseases
in
humans,
animals,
and
plants
is
presence
toxic
materials,
pollutants,
contaminants,
hazardous
compounds
released
by
industries.
One
major
factors
heavy
metals
air,
water
bodies
soil.
Heavy
have
biomagnification
bioaccumulation
characteristics,
making
them
for
flora
fauna
on
a
large
scale.
Recently,
biological
sources
such
as
bacteria,
fungi,
algae,
etc.,
been
used
to
bioabsorb
these
metals.
microbial
properties
cell
walls
are
utilized
effective
low-cost
absorption
Bioaugmentation,
biosorption
biostimulation
strategies
reducing
toxicity
contaminants
soil
facilitating
bioremediation.
mechanism
mainly
based
ions
functional
groups
present
microbes.
Fungal
species
advantageous
over
bacteria
they
easier
handle,
cost-effective
and,
importantly,
non-pathogenic,
ideal
candidates
biosorption.
This
review
provides
comprehensive
overview
various
strains
Further,
highlights
application
nanotechnology
metabolic
engineering
approaches
improve
efficacy
Biosorption,
Biostimulation
Bioaugmentation.
It
insights
role
nanoparticles
bioremediation
prospects
forte
microbe-assisted
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 8, 2024
Veterinary
medications
are
constantly
being
used
for
the
diagnosis,
treatment,
and
prevention
of
diseases
in
livestock.
However,
untreated
veterinary
drug
active
compounds
interminably
discharged
into
numerous
water
bodies
terrestrial
ecosystems,
during
production
procedures,
improper
disposal
empty
containers,
unused
medication
or
animal
feed,
treatment
procedures.
This
exhaustive
review
describes
different
pathways
through
which
enter
environment,
discussing
role
agricultural
practices
methods.
The
detrimental
effects
on
aquatic
ecosystems
elaborated
with
examples
specific
drugs
their
known
impacts.
also
aims
to
detail
mechanisms
by
microbes
degrade
as
well
highlighting
successful
case
studies
recent
advancements
microbe-based
bioremediation.
It
elaborates
microbial
electrochemical
technologies
an
eco-friendly
solution
removing
pharmaceutical
pollutants
from
wastewater.
Lastly,
we
have
summarized
potential
innovations
challenges
implementing
bioremediation
a
large
scale
under
section
prospects
this
field.
